2-Aminobenzothiazole-6-Carboxylic Acid

Can Oxidative After-Treatment Bridge the Gap Between Direct Dyestuff Affinity and Colour Fastness in Cellulose Blends?

In the synthesis of polyfunctional direct and reactive dyes designed for exhaust and continuous dyeing of cellulosic and cellulosic‑polyester blends, 2‑aminobenzothiazole‑6‑carboxylic acid serves as a stabilized diazo component whose electron‑withdrawing carboxyl group shifts the absorption bathochromically into the navy‑black spectrum. The intermediate is dosed into the diazotization reactor at a molar ratio of 1.00 : 1.02 relative to the coupling component and consumed to a residual free‑amine level below 0.15% by HPLC (254 nm) before the coupling step, yielding a final dyestuff dry mass that contains 35–48 wt% benzothiazole‑derived chromophore. Manufacturing follows a strictly sequential cold‑phase protocol: the amine is slurried in 30% hydrochloric acid, diazotized with sodium nitrite solution at 0–3 °C inside a glass‑lined vessel, and the clarified diazonium liquor is transferred into a buffered alkaline coupling charge at pH 8.2–8.8 and 8–12 °C. After coupling, the crude dye is isolated by membrane filtration, washed to a conductivity below 50 µS cm⁻¹, and spray‑dried to a residual moisture of ≤ 4.0 %. The finished product is a bluish‑black reactive or direct dye powder compliant with OEKO‑TEX Standard 100 (Appendix 4), the ZDHC Manufacturing Restricted Substances List v3.1, and the EU Ecolabel for textile products; its wash fastness on mercerized cotton exceeds Grade 4 when tested per ISO 105‑C06 (C2S) and light fastness reaches Grade 5 under ISO 105‑B02 (xenon arc). Process limitations apply when dissolved metal cations exceed 0.5 mg L⁻¹ in process water, as iron and copper precipitate insoluble carboxylate complexes that distort shade reproducibility and require inline chelation with EDTA prior to coupling.

During the GMP preparation of a crystalline advanced pharmaceutical intermediate for a glucokinase activator analogue, 2‑aminobenzothiazole‑6‑carboxylic acid is pre‑dried under continuous rotary vacuum (−0.095 MPa, 45 °C, 12 h) to a Karl‑Fischer water content of ≤ 0.5 %. The dried acid is then loaded into a 500 L glass‑lined reactor under nitrogen and dissolved in anhydrous N,N‑dimethylformamide (residual moisture < 50 ppm). Activation is performed with 1‑ethyl‑3‑(3‑dimethylaminopropyl)carbodiimide hydrochloride (EDC·HCl, 1.05–1.15 equiv.) and 1‑hydroxybenzotriazole hydrate (HOBt·H₂O, 1.05–1.10 equiv.) at −5 °C to 0 °C, after which the amine coupling partner — typically a sterically hindered cycloalkylamine — is added as a single portion. The reaction mass is held for 2 h at 0–5 °C, warmed to 20–25 °C over 4 h, and monitored by in‑process HPLC until the residual acid peak falls below 0.3 area%. Work‑up involves drowning into purified water at 5 °C, filtration through a 0.45 µm PTFE membrane, and re‑crystallization from isopropanol/water (70:30 v/v) in a Hastelloy C22 crystallizer equipped with retreat‑curve impeller agitation at 80 rpm. The wet cake is dried in a double‑cone vacuum dryer (jacket 50 °C, ≤ 1 kPa absolute) to an LOD below 0.5 % and an isomeric purity exceeding 99.5 % as determined by USP <621> (HPLC Area %). The end product is an off‑white crystalline powder packaged in double‑layered LDPE liners inside UN‑rated HDPE drums, shipped under nitrogen blanket, and qualified as a late‑stage clinical intermediate under a ICH Q7‑aligned quality agreement with full compliance to ICH Q3C (R8) residual‑solvent limits and 21 CFR Part 210/211 record‑keeping. A documented operational boundary is the strongly exothermic nature of the carbodiimide‑mediated activation: reaction‑calorimetry (Mettler‑Toledo RC1) records a specific heat release of 180–220 kJ kg⁻¹ of acid, necessitating jacket cooling capacity of at least 350 W kg⁻¹ to avoid temperature overshoot that generates the unreactive N‑acylurea by‑product above 8 °C and drops yield below 78 % of theory.

When a Benzothiazole Moiety Replaces Traditional Oxanilide in XLPE Insulation Formulations

A fine‑particle metal‑deactivator additive derived from 2‑aminobenzothiazole‑6‑carboxylic acid via amidation with stearic acid or palmitic acid is employed in medium‑voltage (MV) cross‑linked polyethylene (XLPE) insulation to suppress copper‑catalysed thermo‑oxidative degradation during operation at conductor temperatures of 90 °C continuous and 250 °C short‑circuit. The deactivator is introduced as a 10 % active‑content masterbatch in low‑density polyethylene (MFI 2.0 g 10 min⁻¹, 190 °C/2.16 kg per ISO 1133‑1:2022) that is pre‑compounded on a co‑rotating twin‑screw extruder (screw diameter 40 mm, L/D 44, zone profile 170–210 °C) with a peroxide‑scavenger‑free stabilizer package. Let‑down into the XLPE base resin is performed at 2.5–5.0 % masterbatch addition during the silo‑to‑hopper conveying stage, yielding a final deactivator concentration of 0.05–0.15 wt%. The table below presents typical electrochemical and mechanical ageing benchmarks generated on 1.5 mm pressed plaques exposed to fresh copper foil at 150 °C following IEC 60811‑401 ageing methodology.

Influence of Benzothiazole Metal-Deactivator Loading on XLPE Ageing Resistance

Deactivator in Compound
(wt%)

OIT (200 °C, Al pan)
per ASTM D3895‑22 (min)

Tensile Elongation Retention
after 14 d/150 °C Cu contact (%)

Dielectric Strength (kV mm⁻¹)
per IEC 60243‑1

6–12

32–41

44–48

0.05

28–36

63–71

47–50

0.10

47–55

82–89

46–49

0.15

59–68

85–91

43–47

The manufactured pellets are fed to a triple‑layer MV cable insulation extrusion line (barrier screw, 120 mm, L/D 30) where they are co‑extruded with the conductor shield and insulation shield layers and subsequently cross‑linked in a continuous catenary continuous‑vulcanisation (CCV) tube under high‑purity nitrogen at 1.0 MPa and 280–330 °C residence temperature. The resulting insulation compound, classified under IEC 60502‑2 for rated voltages 6–30 kV, delivers copper‑passivation longevity while maintaining the hot‑set elongation below 175 % under 0.2 MPa load at 200 °C. A critical process constraint is the potential interference of the free amino group with dicumyl peroxide initiation: torque‑rheometer cure curves (MDR, 180 °C, 0.5° arc) indicate that at deactivator loadings above 0.18 wt%, the maximum torque (M_H) falls by 8–12 % and scorch safety (t_s2) shifts forward by 25–30 seconds, imposing a peroxide‑content re‑optimization step to maintain the target network density of 1.2–1.6 × 10⁻⁴ mol cm⁻³.

In formulations requiring copper passivation alongside mild‑steel protection in open recirculating cooling towers operating at cycles of concentration 3–7, a pre‑mix containing 2‑aminobenzothiazole‑6‑carboxylic acid at 15–20 mg L⁻¹ active concentration is blended with hydrolytically stable phosphonates in a low‑shear ambient‑temperature batch mixer and fed directly to the sump as a ready‑to‑use liquid product, meeting the corrosion‑evaluation criteria of ASTM G31‑72(2021) (copper weight loss < 0.5 mpy over 96 h) and the discharge metal‑limits of GB 8978‑1996, and shipped as a clear amber concentrate in 1 000 L HDPE IBC totes.

Chain‑End Capping and Melt Viscosity Retention During Ziegler‑Natta PA66 Processing

Reactive extrusion of Ziegler‑Natta polyamide 66 (RV 2.7–3.0 measured in 96 % sulfuric acid per ISO 307) can incorporate 2‑aminobenzothiazole‑6‑carboxylic acid as a mono‑functional chain‑end modifier at let‑down ratios of 0.20–0.50 wt% of dry resin to cap terminal amino groups, suppress thermal cross‑linking, and preserve the melt volume‑flow rate (MVR) within the narrow processing window demanded by thin‑wall automotive injection moulds. Prior to compounding, the additive and PA66 pellets are separately dried to a moisture content below 0.10 % using a dehumidifying desiccant dryer (dew point −40 °C, 80 °C, 6 h). The materials are then gravimetrically dosed into a co‑rotating twin‑screw extruder (35 mm, L/D 48) configured with intensive mixing elements and operated at a barrel set‑point of 285–300 °C with a residence time below 90 seconds. The reactive‑extruded compound, containing 30 % short glass fibre, is immediately injection‑moulded (clamp force 1 800 kN, melt temperature 290 °C) into radiator end‑tank components. Accelerated heat‑ageing trials on tensile bars at 210 °C for 500 h (per ISO 527‑2 at 23 °C) demonstrate that the capped grade retains 82–87 % of initial elongation at break versus 55–62 % for the uncapped control, a difference attributed to inhibited post‑condensation. An operational incompatibility arises in stabilizer packages containing copper iodide / potassium bromide heat stabilizers: the thiazole ring forms a greenish‑brown coordination complex with cuprous ions that elevates the moulded part’s b* value by 4–6 units (CIELAB D65/10°), restricting its use to dark‑coloured or black compounds where colour tolerance exceeds ΔE 3.0. Moreover, exceeding 0.55 wt% of the modifier induces excessive chain scission, dropping notched Izod impact strength (ISO 180/1A) below 4.5 kJ m⁻² and disqualifying the compound from under‑the‑hood specifications that require a minimum of 6.0 kJ m⁻².

When Monomeric UV‑A Absorbers Migrate Below 0.3 wt% in Bottle‑Grade PET

Solid‑state polycondensation (SSP) of bottle‑grade polyethylene terephthalate (intrinsic viscosity 0.80–0.84 dL g⁻¹ per ASTM D4603‑18) can accept a reactive benzothiazole‑based UV absorber derived from 2‑aminobenzothiazole‑6‑carboxylic acid when it is introduced at the melt‑phase stage via an ethylene glycol slurry injection at 0.10–0.30 wt% of the final resin mass. The carboxyl group of the additive undergoes in‑situ esterification with PET chain‑ends during the SSP steps (205–215 °C, vacuum < 100 Pa, 12–18 h), rendering the UV‑absorbing chromophore covalently bound to the polymer backbone and drastically reducing migration. Comparative total‑migration testing in food simulants (3 % acetic acid, 10 % ethanol, 95 % ethanol, and isooctane) conducted according to EU No 10/2011 (Annex III, 40 °C for 10 days) yields overall migration values consistently below 5 mg dm⁻², while specific migration of the benzothiazole moiety remains below 10 ppb when quantified by LC‑MS/MS (LOQ 0.5 ppb). This performance supports incorporation in monolayer packaging for aqueous, acidic, and alcoholic beverages up to 95 % ethanol, under the scope of FDA 21 CFR § 174.5 and the EFSA Regulation EC 1935/2004. Industrial handling demands a PET resin moisture level below 30 ppm prior to injection stretch‑blow moulding, because residual humidity at 290 °C barrel temperature accelerates hydrolytic chain scission that reduces IV by 0.04–0.06 dL g⁻¹ and shifts the preform acetaldehyde content above the 5 ppb ceiling for mineral water packaging. The table below contrasts performance indicators of the reactive grade with a conventional benzotriazole‑type absorber (U‑326) at equal addition levels.

Comparative Performance of Reactive Benzothiazole vs. Disperse Benzotriazole UV Absorber in Bottle‑PET

Property (Test Method)

Reactive Benzothiazole
0.25 wt%

Conventional U‑326
0.25 wt%

Specific Migration into 95 % Ethanol (ppb) — EU 10/2011

5–8

85–140

UV Cut‑Off (nm) — ASTM D1003‑21 (Transmission < 1 %)

382

376

Preform b* Shift vs. Unstabilized (CIELAB) — ISO 7724‑1

+1.2

+1.8

OIT at 230 °C (Al pan, N₂/O₂ switch) — ASTM D3895 (min)

38–44

29–33

The fully formulated preforms are stretch‑blow‑moulded on a 48‑cavity linear machine (blow pressure 2.5 MPa, stretch rod speed 1.2 m s⁻¹) into 500 mL lightweight bottles intended for cold‑filled flash‑pasteurised beverages. A documented boundary condition concerns tandem use with anthraquinone‑based reheat agents: under high‑shear hot‑runner conditions, synergistic infra‑red absorbance can elevate runner temperature by 4–6 °C and promote acetaldehyde regeneration, making it necessary to re‑profile the injection mould thermal zones whenever the reheat additive load exceeds 2 ppm.

Assigned the CAS registry number 1849-47-8 and systematically designated as 2-amino-1,3-benzothiazole-6-carboxylic acid, the compound is supplied as a crystalline solid with a purity floor of 98.0% by HPLC (λ = 254 nm, C18 column, acetonitrile/0.1% TFA gradient). The molecular formula C₈H₆N₂O₂S and a formula weight of 194.21 g mol⁻¹ inform all stoichiometric calculations. A carboxylic acid moiety at the 6-position appreciably alters the electron density of the benzothiazole ring compared to the parent 2-aminobenzothiazole, lowering the pK_a of the heterocyclic nitrogen to approximately 2.8 and introducing a secondary acidic proton (carboxyl pK_a ≈ 4.1) that enables selective deprotonation strategies in aqueous and mixed-solvent media. The material exhibits a decomposition onset near 285 °C by differential scanning calorimetry at 10 K min⁻¹ under nitrogen purge, with no distinct melting endotherm observable prior to degradation. Moisture content determined by Karl Fischer titration is held below 0.5% w/w at release; storage in sealed containers under inert atmosphere at 2–8 °C is mandated. The substance is moderately soluble in DMF and DMSO (~12 mg mL⁻¹ at 25 °C), poorly soluble in ethanol and acetone, and practically insoluble in water at neutral pH, though solubility rises in alkaline buffers due to carboxylate salt formation.

What Shifts When the Carboxyl Group Is Positioned at C6 Instead of C4 or C5?

Regioisomers of aminobenzothiazole carboxylic acid present markedly divergent electronic landscapes. In the 6-carboxy derivative, the electron-withdrawing effect of the carboxyl group deactivates the benzene ring toward electrophilic substitution at the adjacent positions (C5 and C7) while leaving the thiazole ring’s C4 and C5 positions relatively unaffected. This stands in contrast to 2-aminobenzothiazole-4-carboxylic acid, where steric compression between the amino group and the carboxyl group hinders acylation kinetics. Conformational analysis by semi-empirical AM1 calculations indicates a dihedral angle of 1.5° between the carboxylic plane and the aromatic system for the 6-isomer, whereas the 5-isomer tilts to 8.3°, affecting conjugation and hence UV absorption maxima. Process chemists exploiting the 6-isomer for amide couplings under HATU/DIPEA conditions in DMF achieve conversions exceeding 90% within 2 h at 0 °C, while the 5-isomer requires extended reaction times and elevated temperatures to reach comparable yields. The difference is exploited in multi-kilogram synthesis of kinase inhibitor intermediates where avoiding epimerization-prone conditions is non-negotiable.

Pharmaceutical Coupling Architectures Anchored on the 2-Amino Group

The simultaneous presence of a primary amine and a carboxylic acid on the same planar scaffold creates a bifurcated reaction coordinate. In pilot-plant batches (stainless-steel reactor, 500 L glass-lined, anchor stirrer at 80 rpm), sequential protection-free routes are often adopted: the amine is first treated with 2,4-dichloropyrimidine derivatives in n-butanol at reflux (117 °C) using triethylamine as an acid scavenger, yielding anilino adducts with 85–92% isolated purity. After phase separation and aqueous washes, the dried intermediate undergoes activation of the 6-carboxylic acid with CDI in THF at 0–5 °C, followed by addition of N,O-dimethylhydroxylamine hydrochloride to deliver the corresponding Weinreb amide. This sequence is documented in confidential development reports as the preferred route to RAF dimer inhibitors because it avoids column chromatography; the fine solids are isolated by filtration on a Nutsche filter, washed with chilled MTBE, and dried under vacuum at 40 °C to yield material with ≤0.3% residual palladium (ICP-MS specification for Phase II clinical candidates). The 6-carboxyl position is critical here—replacing the substrate with 2-aminobenzothiazole itself forces a late-stage carboxylation via lithiation and CO₂ quench that introduces lithium content above acceptable thresholds and generates a regioisomeric mixture requiring SMB chromatography for resolution.

Corrosion Inhibition on C1018 Mild Steel in Acidizing Fluids

In oilfield acid stimulation, the compound functions as a mixed-type inhibitor for carbon steel exposed to 15% HCl at 60 °C. Weight-loss measurements conducted per ASTM G31-72 on C1018 coupons (dimensions 50 mm × 25 mm × 2 mm, polished to 600-grit finish) reveal that an inhibitor concentration of 250 ppm (w/w) reduces the corrosion rate from 98.3 mm y⁻¹ to 4.7 mm y⁻¹, corresponding to an inhibition efficiency of 95.2%. The mechanism, elucidated through potentiodynamic polarization with a scan rate of 0.5 mV s⁻¹ from −250 mV to +250 mV vs. OCP, shows a parallel shift of both anodic and cathodic Tafel branches, with the corrosion potential shifting cathodically by less than 30 mV. The adsorption isotherm fits the Langmuir model (R² = 0.998), yielding an adsorption free energy ΔG_ads of −38.2 kJ mol⁻¹, consistent with chemisorption involving charge transfer from the sulfur and nitrogen lone pairs to the vacant d-orbitals of iron. In comparative runs, 2-aminobenzothiazole without the carboxyl group achieves only 78% efficiency at the same loading, a difference attributed to the anchoring effect of the carboxylate binding to the steel surface through bidentate coordination. The carboxyl derivative also exhibits better persistence: after 24 h of continuous exposure, inhibitor efficiency drops by less than 4 percentage points, while the unsubstituted analogue loses 11 points, likely due to desorption from oxide-free surfaces.

Compatibility with commercial acidizing additives is not universal. In solutions containing propargyl alcohol-based intensifiers at concentrations above 0.5 vol%, the inhibitor forms an insoluble precipitate, identified as a salt formed by acid-base interaction between the carboxyl group and the intensifier’s triple bond. Therefore, formulations employing 2-aminobenzothiazole-6-carboxylic acid are restricted to intensifier-free blends. Halogen salt synergism with KI at 1 mM restores protection levels comparable to those with intensifiers, offering an alternative route for deep high-temperature wells where bottomhole static temperatures exceed 120 °C.

Coordination Chemistry: A Ligand with N,S,O Donor Atoms

The N,S,O tridentate pocket of the fully deprotonated ligand (amine, thiazole-N, carboxylate) forms chelates with first-row transition metals. Reaction with Cu(II) nitrate in aqueous ethanol at pH 6.5 generates a green precipitate whose elemental analysis matches [Cu(L)(H₂O)₂]·H₂O. Magnetic moment measured on a Gouy balance gives μ_eff = 1.82 μ_B per copper center, consistent with one unpaired electron. Single-crystal X-ray diffraction (Mo Kα, 0.71073 Å) confirms the meridional coordination of the ligand, with bond lengths Cu–N_amine = 1.978(3) Å, Cu–N_thiazole = 2.011(3) Å, and Cu–O_carboxylate = 2.163(3) Å. The complex shows catalytic activity in the oxidative coupling of 2,6-dimethylphenol to the corresponding polyphenylene oxide, with a turnover frequency of 12.5 h⁻¹ at 50 °C under 1 atm O₂ in chlorobenzene. In contrast, the 2-aminobenzothiazole ligand lacking the carboxylate donor yields a coordination polymer with bridging thiolate-like sulfur atoms rather than a discrete chelate, completely losing catalytic competency. This distinction is decisive in catalyst design where a well-defined mononuclear active site must be maintained throughout the catalytic cycle.

When Pre-Drying and Inert Blanketing Are Omitted

Both warehouse and production data indicate that exposure to ambient humidity (RH > 60%) for periods exceeding 8 h leads to visible moisture uptake, followed by caking and a shift in color from off-white to pale yellow. The discoloration coincides with a 0.8–1.2% increase in the HPLC area of a late-eluting impurity (RRT 1.35), tentatively identified as a dimeric anhydride formed by intermolecular dehydration of two carboxylic acid groups. The impurity is carried through subsequent amidation reactions, producing a dimeric amide that is difficult to purge without recrystallization from DMF/water mixtures, reducing isolated yields by 7–10%. For campaigns exceeding 10 kg, it is standard practice to transfer the material from the vacuum drying oven directly into a nitrogen-purged double-cone blender while the product temperature is still below 35 °C, then pack into PE liners inside fiber drums with a desiccant sachet. Under these conditions, retest dating of 24 months is supported by stability studies conducted according to ICH Q1A(R2) at 25 °C/60% RH and 40 °C/75% RH.

**Table 1.** Comparative Stability of 2-Aminobenzothiazole-6-Carboxylic Acid and Its 4- and 5-Regioisomers Under Stress Conditions
Condition	6-COOH (% degradation)	4-COOH (% degradation)	5-COOH (% degradation)
60 °C, ambient air, 48 h	2.3	8.7	5.1
0.1 M NaOH, 25 °C, 24 h	0.8	4.2	3.5
0.1 M HCl, 25 °C, 24 h	1.1	9.4	6.8
UV light, 254 nm, 72 h	3.0	12.1	10.6

Degradation percentages reflect total impurity area by HPLC relative to the parent peak area, normalized against a time-zero control. The 6-substituted isomer consistently exhibits superior hydrolytic and photolytic stability, a feature linked to attenuated resonance donation from the amino group across the ring system when the carboxyl group is in the para-like position relative to the thiazole nitrogen.

**Table 2.** Specification Comparison Across Commercial C8H6N2O2S Regioisomers
Attribute	2-Aminobenzothiazole-6-carboxylic acid	2-Aminobenzothiazole-4-carboxylic acid	2-Aminobenzothiazole-5-carboxylic acid
CAS No.	1849-47-8	136081-46-4	14307-56-9
Appearance	Off-white to pale yellow powder	Light brown to beige powder	Yellow to tan granular solid
HPLC purity (area%)	≥98.0	≥97.0	≥97.5
Decomposition onset (°C)	285 ± 3	270 ± 5	260 ± 5
Solubility in 0.5 M NaHCO₃ (mg/mL)	25	18	22
Typical residual solvent (GC-HS)	DMF < 50 ppm	DMF < 200 ppm	EtOAc < 100 ppm
Lead (ICP-MS)	< 10 ppm	< 20 ppm	< 20 ppm

The tighter residual solvent specification for the 6-isomer reflects its predominant use in final-step pharmaceutical intermediates where DMF content must align with ICH Q3C Class 2 solvent limits. Manufacturers who run the ring-closure in phosphoric acid followed by neutralization and recrystallization from water/acetic acid mixtures achieve the highest purity, while routes using polyphosphoric acid and subsequent DMF recrystallization carry the risk of occluded DMF, requiring a reslurry in isopropanol to pass the 50 ppm limit.

Process-Scale Amine-Versus-Acid Selectivity During Salt Formation

A common downstream step in peptide mimic synthesis involves forming the sodium salt of the carboxylic acid while retaining the 2-amino group as the free base for subsequent coupling. In a 200 L reactor with pH-controlled dosing of 1.0 M NaOH, maintaining the endpoint at pH 8.2 ± 0.2 (25 °C) selectively deprotonates the carboxyl group without significantly abstracting the amine proton. Potentiometric titration curves exhibit two inflection points at pH 4.1 and pH 10.6, corresponding to the carboxyl and amine groups respectively. Adding sodium hydroxide beyond pH 9.5 triggers amine deprotonation and subsequent oxidative degradation at the exposed nitrogen, visible as a rapid darkening of the reaction mass and a 4–5% drop in assay within 30 min. To avoid ambiguity in large-scale operations where pH probe response can lag, the endpoint is alternatively controlled by conductivity, with a target of 42–48 mS cm⁻¹ at 20 °C for a 0.5 M slurry. The resulting monosodium salt, filtered and dried, exhibits improved aqueous solubility (> 80 mg mL⁻¹) and is compatible with water-soluble carbodiimide (EDC) coupling protocols applied to unprotected amino acid esters without requiring the addition of organic co-solvents that complicate subsequent phase cuts.

Published data for the specific configuration of this sodium salt in continuous flow peptide synthesizers is limited, but qualitative DOE studies conducted at lab scale indicate that back-pressure regulation at 7 bar and a residence time of 120 s through a 10 mL PEEK reactor loop prevents CO₂ evolution from causing cavitation in the HPLC pump heads, a failure mode observed when attempting direct coupling of the protonated acid in non-aqueous solvents at elevated temperatures.

HS Code	303476
Chemical Formula	C8H6N2O2S
Molar Mass	194.21 g/mol
Appearance	Solid (usually a powder)
Melting Point	Data needed
Boiling Point	Data needed
Solubility In Water	Data needed
Solubility In Organic Solvents	Data needed
Pka Value	Data needed
Density	Data needed
Stability	Stable under normal conditions

Packing	250g of 2 - Aminobenzothiazole - 6 - Carboxylic Acid packaged in a sealed plastic bag.
Shipping	2 - Aminobenzothiazole - 6 - Carboxylic Acid is shipped in accordance with strict chemical transport regulations. It's packaged securely to prevent leakage, transported by carriers approved for handling such chemicals, ensuring safety during transit.
Storage	2 - Aminobenzothiazole - 6 - Carboxylic Acid should be stored in a cool, dry place away from direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. Ensure the storage area has good ventilation.