1-[(4-Methylphenyl)Sulfonyl]-1H-Pyrrole

Depsipeptide Macrocyclization via Transient Sulfonamide Activation

Cyclization of linear depsipeptide precursors using 1-[(4-Methylphenyl)Sulfonyl]-1H-Pyrrole exploits the electron-withdrawing character of the sulfonyl group to polarize the pyrrole C2 position, enabling nucleophilic aromatic substitution by serine or threonine hydroxyl side chains. The tosylated pyrrole is incorporated in stoichiometric ratio onto the growing peptide chain on 2-chlorotrityl chloride resin preloaded at 0.4–0.8 mmol/g. Coupling is mediated by HATU and HOAt in DMF with 2,4,6-collidine as base, achieving coupling efficiencies exceeding 98% as monitored by Kaiser test. The subsequent cyclization-release step occurs in 1% TFA in DCM, where the acid-labile resin linkage cleaves, and intramolecular displacement of the tosylpyrrole generates the macrocyclic lactone or lactam.

Compliance under FDA 21 CFR 211 Subpart D requires validation of residual palladium from peptide coupling catalysts to below 10 ppm, quantified by ICP-MS, and residual solvent analysis per USP 〈467〉 for DMF (Class 2, limit 880 ppm). This methodology produces cyclic depsipeptides in the molecular weight range of 500–1200 Da, encompassing clinical candidates such as histone deacetylase inhibitors, antifungal echinocandin analogs, and orally bioavailable integrin antagonists. The solid-phase process eliminates solution-phase macrolactamization challenges, including oligomerization at concentrations above 0.001M, and enables direct scale-up on automated peptide synthesizers with 10–50 mmol resin capacity.

Control of the resin loading is critical: densities exceeding 0.9 mmol/g induce site-site interactions that reduce cyclization yields by 15–25% absolute, as confirmed by comparative Kaiser and Fmoc cleavage monitoring. The tosyl activating group is preferred over p-nitrophenyl or pentafluorophenyl leaving groups when downstream hydrogenation steps are incompatible with nitro group contaminants.

Residual Impurity Thresholds in Tosylpyrrole-Processed APIs (Per ICH/Ph. Eur.)

Impurity Species

Analytical Method

Acceptance Limit

4-Methylbenzenesulfonic acid

HPLC-UV at 220 nm

≤0.10% w/w

Residual pyrrole (unreacted)

GC-FID, DB-624 column

≤0.05% w/w

Sodium naphthalenide (deprotection)

IC (conductivity)

≤50 ppm as Na⁺

Dimethoxyethane (solvent)

HS-GC-MS (ICH Q3C)

≤100 ppm (Class 2)

Heterocyclic Scaffold Diversification in Kinase-Directed Libraries

In the synthesis of pyrrolo[2,3-d]pyrimidine and pyrrolo[3,2-c]pyridine cores that populate Type I and Type II kinase inhibitor chemical libraries, the tosylpyrrole serves as a pre-functionalized C2/C3-directing building block. The sulfonyl group withdraws electron density from the pyrrole ring, deactivating it toward electrophilic bromination at C3 while permitting lithiation at C2 with LDA in THF at −78°C. This regiochemical control is essential for constructing 2,3-disubstituted pyrrole pharmacophores found in JAK2, BTK, and CDK4/6 inhibitors.

Addition of 1-[(4-Methylphenyl)Sulfonyl]-1H-Pyrrole at 1.05 equivalents in the initial Suzuki-Miyaura coupling step employs Pd(PPh₃)₄ (2 mol%) and aqueous Na₂CO₃ in dioxane at 85°C, achieving cross-coupling at C2 with boronic acid partners before tosyl group removal with tetrabutylammonium fluoride in THF at 60°C over 3 hours. The liberated pyrrole nitrogen is then alkylated or acylated to install solubility-modulating side chains. This sequence is validated by Reaction Monitoring via ¹⁹F NMR when fluorinated coupling partners are employed, providing real-time conversion data without aliquot quenching.

The GMP synthesis of a clinical-stage BTK inhibitor utilized this exact tosylpyrrole intermediate in three consecutive pilot campaigns totaling 42 kg of final API, with the tosyl-directed lithiation step achieving 94% regioselectivity (C2:C3 ratio > 30:1) as determined by ¹H NMR integration of the isolated regioisomers. Any deviation in LDA addition temperature above −70°C resulted in C3 lithiation increasing to 8–12%, producing an inseparable regioisomeric impurity that carried through to the final compound and exceeded the 0.10% unspecified impurity threshold of ICH Q3A. The process specification therefore mandates jacketed reactor cooling with a ±3°C control band.

Polypyrrole thin films electrodeposited onto platinum or ITO-coated glass electrodes incorporate the tosyl-substituted monomer to modulate film morphology and ion-exchange capacity. Electrochemical polymerization in acetonitrile containing 0.1 M tetrabutylammonium hexafluorophosphate as supporting electrolyte, with the monomer at 0.05 M, yields adherent films at a constant current density of 0.5–1.0 mA/cm². The tosyl group remains intact during electropolymerization, as the oxidative coupling occurs exclusively at the pyrrole C2 and C5 positions, leaving the N-sulfonamide linkage undisturbed.

Cyclic voltammograms of the resulting films in monomer-free electrolyte exhibit a quasi-reversible redox couple at +0.35 V vs. Ag/AgCl (3M NaCl), with the tosyl substituent shifting the oxidation potential anodically by approximately 120 mV relative to unsubstituted polypyrrole, attributed to the electron-withdrawing sulfonyl. The films display electrochromic switching from a reduced blue-black state to an oxidized pale yellow state, with a coloration efficiency of 175 cm²/C at 550 nm and a switching time of 1.2 seconds for 50% transmittance change in films of 0.3 μm thickness.

These modified polypyrrole films function as the electroactive layer in amperometric biosensors for glucose (with immobilized glucose oxidase), achieving a linear detection range of 0.05–15 mM glucose in phosphate-buffered saline at pH 7.4, with inter-electrode reproducibility of RSD 4.2% (n=6 electrodes). The anti-interference properties against ascorbic acid and uric acid are attributed to the permselectivity of the tosylated film, which discriminates against anionic interferents at the operating potential of +0.60 V vs. Ag/AgCl. Sensor fabrication follows ISO 13485 design control procedures and the analytical validation parameters of CLSI EP17-A2 for limit of detection determination.

For solid-contact ion-selective electrodes targeting potassium and calcium, the tosylpyrrole is copolymerized with 3-octylpyrrole at a 1:3 molar ratio to produce a hydrophobic transducer layer between the ion-selective membrane and the glassy carbon electrode substrate. The resulting electrodes exhibit a Nernstian slope of 57.8 ± 0.4 mV/decade for K⁺ over the activity range 10⁻⁵ to 10⁻¹ M (R² = 0.9994), with the hydrophobic sulfonamide component preventing water layer formation at the membrane-electrode interface, thus eliminating the potential drift of 2–5 mV/hour commonly observed in non-tosylated polypyrrole transducers during continuous monitoring in undiluted whole blood.

Bench-scale hydrogenations of tosyl-protected pyrrole substrates over heterogeneous catalysts often encounter catalyst poisoning when trace sulfonamide degradation products adsorb irreversibly onto palladium or platinum surfaces. In a documented kilo-lab scenario, a palladium-on-carbon (10% Pd/C, wet, Johnson Matthey type 87L) hydrogenation of a tosylated pyrrole-carboxylate intermediate at 50 psi hydrogen in ethanol at 45°C exhibited a drop in reaction rate from a first-order rate constant of 0.12 min⁻¹ to 0.03 min⁻¹ after the third catalyst recycle. Elemental analysis of the deactivated catalyst by XPS revealed sulfur 2p signals at 163.8 eV and 168.2 eV, diagnostic of adsorbed thioether and sulfonate species respectively.

This poisoning was traced to a slow, base-catalyzed desulfonylation side reaction that generated 4-methylbenzenesulfinate ion in the presence of residual triethylamine from an earlier synthetic step. The solution involved an acidic aqueous wash (1M HCl, 2 × 50 mL) of the substrate solution prior to charging the hydrogenation vessel, which removed basic residues and suppressed desulfonylation. Post-wash, the catalyst retained 88% of its initial activity across five consecutive hydrogenation cycles, as monitored by hydrogen uptake curves recorded on a Büchi Miniclave with gas-flow measurement. The sulfinate contamination threshold was established at < 500 ppm by ion chromatography (Dionex IonPac AS19 column) to maintain catalyst turnover exceeding 5000 mol substrate/mol Pd.

In the preparation of low-molecular-weight (200–500 Da) sulfonamide drug candidates intended for oral administration, 1-[(4-Methylphenyl)Sulfonyl]-1H-Pyrrole serves as a direct synthetic precursor for compounds bearing both sulfonamide and pyrrole pharmacophoric elements. Carbonic anhydrase IX inhibitors, which are sulfonamide-dependent zinc-binding metalloenzyme antagonists overexpressed in hypoxic tumor microenvironments, have been prepared by alkylating the de-tosylated pyrrole at the nitrogen position with α-bromoacetamide derivatives, followed by sulfonamide group retention at the 4-position of the benzenesulfonamide fragment.

Bioavailability optimization requires a log D (octanol/water, pH 7.4) between 1.0 and 3.0, achieved by balancing the hydrophilic sulfonamide (clogP contribution ≈ −1.5) with lipophilic N-alkyl substituents on the pyrrole core. The synthesis proceeds via N-alkylation of the sodium salt of the parent sulfonamide with 1.1 equivalents of alkyl bromide in DMF at 60°C, followed by selective sulfonamide deprotection using magnesium turnings in methanol at 0°C, a method that preserves the primary sulfonamide on the aryl ring while cleaving the N-tosyl group on the pyrrole. Final compounds are purified by reverse-phase preparative HPLC (C18, acetonitrile/water + 0.1% TFA) to 99.5% purity by area normalization at 254 nm, with structure confirmation by high-resolution mass spectrometry (Q-TOF, ESI+).

Process Parameter Comparison — Tosylpyrrole Deprotection Methods

Method

Reagent System

Temperature / Time

Pyrrole N–S Cleavage Selectivity

Applicable Substrates

Reductive

Sodium naphthalenide, DME

−78°C / 30 min

Excellent (no aryl sulfonamide cleavage)

Base-sensitive esters, epimerizable centers

Alkaline

NaOH 6N, EtOH/H₂O reflux

78°C / 12–24 h

Moderate (competitive aryl SO₂NH₂ hydrolysis)

Acid-stable, non-racemizable substrates

Fluoride-mediated

TBAF 1.0M in THF

60°C / 3 h

Excellent

Broad; incompatible with silyl ethers

Dissolving metal

Mg turnings, MeOH

0°C / 1 h

Selective for N-SO₂ over aryl-SO₂NH₂

Sulfonamide-containing compounds

Acidic

HBr 33% in AcOH

25°C / 6 h

Poor (indole/pyrrole degradation)

Limited; robust heterocycles only

Benzaldehyde-derived hydrazones of tosylpyrrole-2-carboxaldehyde, prepared in yields exceeding 85% by condensation in refluxing ethanol with a catalytic amount of glacial acetic acid, form air-stable complexes with first-row transition metals including Cu(II), Ni(II), and Co(II). These complexes are synthesized by stirring the hydrazone ligand (1.0 mmol) with the metal acetate hydrate (0.5 mmol) in methanol at 50°C for 4 hours, precipitating the product directly from the reaction mixture. Single-crystal X-ray structures of the Cu(II) complexes confirm square-planar N₂O₂ coordination geometry, with the tosyl group occupying a non-coordinating position that does not interfere with metal binding.

Gravimetric metal uptake studies by quartz crystal microbalance (QCM-D, QSense E4) on spin-coated films of these metal complexes exposed to ammonia vapor at 500 ppb in a humidity-controlled chamber (relative humidity = 40%) at 23°C demonstrate frequency shifts corresponding to reversible mass loading of 8.2 ng/cm² over 120 seconds of exposure, with desorption complete within 90 seconds of purging with dry nitrogen. The response is linear over the concentration range 50–2000 ppb ammonia (R² = 0.993), with a calculated limit of detection of 12 ppb (S/N = 3) on the fundamental frequency (5 MHz). Sensor selectivity against humidity and carbon dioxide is enhanced by the hydrophobic tosyl substituents, which reduce water uptake by approximately 60% compared to non-sulfonylated pyrrole-hydrazone complexes as measured by environmental ellipsometry.

1-[(4-Methylphenyl)Sulfonyl]-1H-Pyrrole (CAS 17639-64-4, molecular weight 221.28 g/mol) — commonly identified by its crystalline, off-white powder morphology — is a nitrogen-protected pyrrole derivative that has been qualified as a versatile C₄-synthon in heterocyclic construction and pericyclic process chemistry. The compound is routinely supplied under catalogue designators such as Sigma-Aldrich 729930 and TCI America T3509, with batch certificates reporting purity ≥ 98.0% (HPLC, detection at 254 nm per Ph. Eur. 2.2.29) and water content ≤ 0.5% (Karl Fischer titration, ASTM E203). Its core utility resides in regioselectively masking the pyrrole N–H, which suppresses aerobic darkening, alters the π-electron demand of the ring, and enables controlled metalation at the α-positions for subsequent cross-coupling or electrophilic quenching sequences. In contrast to 1-(phenylsulfonyl)pyrrole, the para-methyl substituent on the arenesulfonyl group increases steric bulk without significantly perturbing the IR asymmetric S=O stretching band near 1365 cm⁻¹, a factor that can affect crystallization kinetics during solvent evaporation from reaction mixtures.

What limits the diastereoselectivity in high-pressure Diels–Alder reactions employing this N-protected pyrrole?

Under hyperbaric conditions (≥ 1.2 GPa), 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole acts as an electron-deficient diene that engages typical dienophiles like dimethyl acetylenedicarboxylate (DMAD) through an inverse-electron-demand pathway. Observed endo/exo ratios, when analyzed via ¹H NMR quantification of bridgehead proton signals at 400 MHz, can shift from 4.2:1 to 1.7:1 as the solvent polarity moves from dichloromethane (ε 8.9) to acetonitrile (ε 37.5). A critical processing window exists at 85–92 °C in a BÜCHI miniclave steel-1 vessel equipped with a PTFE liner; exceeding 95 °C leads to retro-cycloaddition and production of oligomeric tar characterized by GPC (THF, RI detector) weight-average molar masses M_w above 12 000 Da. Published data for enantioselective variants with chiral Lewis acids remains limited, although evidence from the 1-nosylpyrrole analog suggests that once the tosyl group is replaced by the more electron-withdrawing 4-nitrobenzenesulfonyl auxiliary, facial discrimination in ytterbium(III)-tris[(R)-1,1′-bi-2-naphthoxide]-catalyzed systems can attain enantiomeric excess values beyond 90%.

Electrophilic substitution patterns in N-tosylpyrrole versus N-Boc-pyrrole under Vilsmeier–Haack formylation

When treated with the standard Vilsmeier–Haack reagent (PBr₃/DMF, 0–5 °C), 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole yields the 2-formyl derivative with a regioselectivity of 96:4 over the 3-isomer, as determined by GC-MS on an Agilent HP-5MS column (30 m × 0.25 mm, 0.25 μm film). This outcome differs markedly from 1-Boc-pyrrole, where the formylation occurs preferentially at the 3-position (89:11 3- vs. 2-formyl) under identical conditions. The divergence is attributed to the tosyl group’s ability to stabilize the Wheland intermediate at the α-carbon through a combination of inductive withdrawal and resonance delocalization of the lone pair on the sulfonyl oxygen—an effect absent in the carbamate system. Scale-up batches exceeding 500 g at a CDMO facility (20 L jacketed glass reactor, pitch-blade impeller at 180 rpm) have experienced exotherms up to ΔT = +14 °C during reagent addition unless the phosphonium salt formation is controlled by a dosing rate limited to 8.0 mL/min via a peristaltic pump. Work-up requires quenching into ice-cold 2.0 M sodium acetate buffer (pH 5.2), and emulsions that persist beyond 45 min are broken only by the addition of brine containing 0.01 wt% cetyltrimethylammonium bromide.

Typical specification ranges for 1-[(4-Methylphenyl)Sulfonyl]-1H-Pyrrole (bulk supply, research grade)
Parameter	Method/Reference	Acceptance criterion
Appearance	Visual inspection under D65 illuminant	White to pale cream crystalline powder
Assay (HPLC)	Ph. Eur. 2.2.29, C18 column, MeCN/H₂O 65:35, 1.0 mL/min	≥ 98.0 area%
Melting point	USP <741>, capillary, ramp 2 °C/min	100–104 °C
Water (KF)	ASTM E203, volumetric titrator	≤ 0.5%
Sulfated ash	Ph. Eur. 2.4.14	≤ 0.1%
Residual solvents (GC)	USP <467> headspace	Toluene ≤ 890 ppm, EtOAc ≤ 5000 ppm
Storage condition	—	Store at +2 to +8 °C, argon blanket

When comparing this reagent with alternative N-sulfonylated pyrroles, the balance between protective-group robustness and deprotection gentleness dictates process selection. 1-[(4-Methylphenyl)sulfonyl]-1H-pyrrole resists acidic hydrolysis up to 3.0 N HCl in refluxing THF for 6 h, whereas the corresponding 4-nitrobenzenesulfonyl (nosyl) derivative undergoes 15% cleavage in 1.0 N HCl within 30 min. This acid stability makes the tosyl variant suitable for strongly acidic post-functionalizations—for instance, nitration with acetyl nitrate in acetic anhydride at –10 °C—though it simultaneously demands more aggressive reductive conditions for removal: sodium naphthalenide in DME at –78 °C delivers the free pyrrole in 85% isolated yield, whereas magnesium turnings in methanol (r.t., 18 h) typically achieve only 62% conversion. For kilogram-scale campaigns producing advanced pharmaceutical intermediates (e.g., substituted indoles via [4+2] cycloaddition-decarboxylation cascades), the extended processing time of magnesium/methanol has been addressed by switching to a continuous flow reactor equipped with a packed-bed column of activated Rieke magnesium, reaching residence times of 8 min at 60 °C and full conversion.

Irreversible discoloration threshold during melt processing and hot-melt stabilization

Analytical hot-stage microscopy (Mettler Toledo FP82HT, heating rate 5 °C/min) indicates that a melt held at 110 °C for 20 min develops a color shift from ΔE*ab 2.3 to 9.8 (CIE L*a*b*, D65/10° observer) when the headspace contains 21% O₂. This oxidative darkening coincides with the appearance of a new HPLC peak at RRT 1.33, which LC-MS (ESI⁺) associates with a sulfone-to-sulfinate rearrangement product. Mitigation demands purging with argon until residual oxygen levels measured by a Teledyne 311 trace oxygen analyzer fall below 50 ppmv, and the addition of 0.1 wt% butylated hydroxytoluene extends the ΔE*ab stability plateau to 90 min at 110 °C. This behavior contrasts with 1-(phenylsulfonyl)pyrrole, where the absence of the para-methyl group lowers the melt viscosity sufficiently to allow self-degassing at 100 °C and correspondingly reduces the required BHT loading by half.

Why are palladium-catalyzed direct arylations at the C2–H position sensitive to the sulfonyl leaving group’s electronic profile?

The C2–H bond of 1-tosylpyrrole undergoes Pd(OAc)₂-catalyzed coupling with aryl bromides in the presence of P(t-Bu)₃ and K₂CO₃ in DMAc at 120 °C. Isolated yields for 4-bromotoluene coupling range from 68–73% across three validation batches (n = 3, 10 mmol scale). When the tosyl group is replaced by the less electron-demanding methanesulfonyl (mesyl) moiety, the oxidative addition barrier increases, dropping the yield to 44–49% under identical conditions. Cyclic voltammetry (glassy carbon electrode, 0.1 M Bu₄NPF₆ in DMF, scan rate 100 mV/s) confirms that the onset oxidation potential for the tosyl derivative is +1.17 V vs. Ag/AgCl, 140 mV lower than that of the mesyl analog, facilitating the CMD (concerted metalation-deprotonation) step by increasing the electron density at the palladated α-carbon. This property positions 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole as the preferred substrate in C–H functionalization sequences aimed at constructing biaryl architectures when electron-rich aryl bromides are employed; when electron-poor aryl bromides (e.g., 4-cyanobromobenzene) are used, the nosyl congener outperforms due to its higher C2–H acidity and reduced carbon-palladium protonolysis side reaction.

Comparative deprotection performance: tosyl vs. alternative sulfonyl auxiliaries on pyrrole
Sulfonyl group	Cleavage method	Time	Temp.	Isolated yield free pyrrole (%)	Residual sulfonamide (ppm)
4-Toluenesulfonyl (Ts)	Na/naphthalene, DME	20 min	–78 °C	85	≤ 300
4-Toluenesulfonyl (Ts)	Mg turnings, MeOH	18 h	22 °C	62	1200–1600
4-Nitrobenzenesulfonyl (Ns)	Thiophenol, K₂CO₃, DMF	1.5 h	25 °C	92	≤ 50
4-Bromobenzenesulfonyl (Bs)	Zn dust, NH₄Cl, THF/H₂O	3 h	60 °C	78	400–600
Methanesulfonyl (Ms)	KOH, dioxane/H₂O, reflux	8 h	100 °C	41	2500+

During prolonged storage at +2 to +8 °C, 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole exhibits a static-charge-driven clumping tendency dependent on relative humidity (RH). At RH ≥ 55%, particle size distribution measured by laser diffraction (Malvern Mastersizer 3000, dry dispersion) shifts from a D₅₀ of 42 µm to agglomerates with D₅₀ 210 µm within 72 h. Pre-drying of the container headspace with a silica gel cartridge and inclusion of Tyvek® desiccant sachets restores flowability; nonetheless, facilities in tropical climates (annual mean RH 80%) have reported that moisture ingress through LDPE inner liners can elevate water content above 0.8% after six months, exceeding the specification limit. Under such boundary conditions, repackaging in aluminum-laminated foil pouches with heat-seal integrity tested per ASTM F88/F88M-21 is advised. Compatibility with common laboratory solvents has been systematically tested: the compound is soluble in THF, DMF, and DMSO at ≥ 200 mg/mL; it is only sparingly soluble in water (0.12 mg/mL at 25 °C, shake-flask UV method at 262 nm), which limits its use in purely aqueous reaction media without phase-transfer catalysts.

Process chemists scaling a three-step sequence (tosylation of pyrrole with p-toluenesulfonyl chloride in the presence of tetrabutylammonium hydrogen sulfate, subsequent Diels–Alder cycloaddition, and final desulfonylation) have reported that residual DMAc solvent carried into the desulfonylation stage forms a coordination complex with the Na/naphthalenide reducing agent that inhibits cleavage. The process deviation was traced to a thin-film evaporator operating at 2.0 mbar and 45 °C jacket temperature; reducing the evaporator’s feed rate to 1.5 kg/h and increasing the rotor speed to 350 rpm brought the DMAc level below 700 ppm (determined by GC-FID), restoring desulfonylation yields to their 80–85% range. This experience underscores the importance of 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole as a synthetic intermediate whose logistics, not merely its bench reactivity, define the overall process economic window.

Is the 4-methylphenyl substituent truly inert under photoredox conditions?

Under irradiation from a 34 W blue LED array (λ_max = 450 nm, photon flux density 18 mW/cm²), 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole combined with an iridium(III) photocatalyst (fac-Ir(ppy)₃, 0.5 mol%) undergoes single-electron oxidation, generating a radical cation that adds to styrene derivatives in moderate to good yields (55–72%) for hydro-functionalization reactions. Notably, the tosyl group itself resists C–S bond cleavage under these conditions, whereas the 4-bromobenzenesulfonyl (brosyl) protective group suffers 6–8% debromination side-product after 16 h of irradiation. This stability is a differentiator when visible-light-mediated C–C bond formations are planned; the 1-tosylpyrrole radical cation preferentially reacts at the α‑position rather than at the sulfonamide linkage, avoiding the formation of sulfinate waste that complicates chromatographic purification. The photochemical quantum yield (Φ) measured by ferrioxalate actinometry falls to 0.11 when the tosyl substrate is used compared to 0.24 for the N-methylpyrrole analogue, attributed to the tosyl group’s steric shielding that slows diffusion-controlled radical recombination.

HS Code	739829
Chemical Formula	C11H11NO2S
Molecular Weight	223.275 g/mol
Appearance	Solid (usually)
Physical State At Room Temperature	Solid
Solubility In Water	Low (organic compound, typically less soluble in water)
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Odor	Odor may vary, often has an organic - chemical odor
Stability	Stable under normal conditions if stored properly

Packing	100g of 1 -[(4 -Methylphenyl)sulfonyl]-1H -pyrrole packaged in a sealed plastic bottle.
Shipping	1 - [(4 - Methylphenyl)sulfonyl]-1H - Pyrrole is shipped in well - sealed, corrosion - resistant containers. Packing ensures protection from external factors during transit to prevent spills and maintain chemical integrity.
Storage	1 - [(4 - Methylphenyl)sulfonyl]-1H - pyrrole should be stored in a cool, dry place away from direct sunlight. Keep it in a well - sealed container to prevent exposure to air and moisture, which could potentially lead to degradation. Store it separately from incompatible substances, like strong oxidizing agents or bases, in a dedicated chemical storage area.