Thiophene-2-Ethylamine stands as an aromatic amine, featuring a thiophene ring connected by an ethyl chain to an amino group. Chemists recognize its structure by the formula C6H9NS, placing it among organic compounds with both a heterocyclic backbone and an amine function. The molecular weight clocks in at 127.21 g/mol, making it relatively lightweight for processes needing a fine balance between ring-stability and reactivity. In the lab, you actually see tiny solid flakes or a crystalline powder, and depending on purity and temperature, this compound may shift from solid to a viscous liquid. Right from the glass bottle, Thiophene-2-Ethylamine brings a faint amine smell, not overpowering, but strong enough to signal its chemical identity.
Look at the density—typically in the range of 1.1 to 1.2 g/cm³—which reflects its solid nature at room temperature. Melting occurs above 40°C, while on heating in an open flask, decomposition sets in before it really boils. The molecular structure guarantees solubility in polar solvents like ethanol, with only moderate behavior in water, so mixing into most water-based systems takes a little coaxing. In the bottle, you might see flakes or powder, but some suppliers offer pearls or granulated forms, all aiming for ease of measurement and dose accuracy in lab conditions. Chemists value clear specifications like purity (often >98%), moisture content (ideally <0.5%), and minimal heavy metals, as these numbers matter for consistent performance.
The backbone—a thiophene ring, which is a five-membered structure with one sulfur atom—grants aromatic stability and a certain reactivity profile. The ethylamine group at the 2-position offers a basic amine site, key for both nucleophilic reactivity and interactions with acids or reactive intermediates. In most chemical reactions, this structure opens up pathways to pharmaceuticals, agricultural compounds, and specialty dyes, thanks to the dual action of the sulfur ring and amine functionality. The presence of sulfur, nitrogen, and a compact carbon framework makes it an important raw material for advanced chemical synthesis, especially where selective amination or ring modifications drive innovation.
On the global market, Thiophene-2-Ethylamine falls under HS Code 293499, which covers “other heterocyclic compounds.” For customs, this ensures clear categorization, informing duties, trade protocols, and international shipment requirements. Regulatory agencies look at both its amine content and thiophene ring for transport and safety labeling. Manufacturers need to check country-specific import requirements and maintain compliance with REACH or TSCA where trade routes touch Europe or the United States.
Direct skin or eye contact with Thiophene-2-Ethylamine can trigger irritation, as the compound shows typical amine alkali features. Swallowing or breathing dust or vapors carries health hazards, with potential for headaches, nausea, or, in severe cases, more systemic effects. Chemists working with this substance wear gloves, safety goggles, and use fume hoods to keep exposure low. Spills require careful neutralization and disposal, always as hazardous waste, because of both its chemical nature and the risk of environmental harm if released unchecked. Proper storage calls for airtight containers, low humidity, and cool, stable temperatures—avoiding any accidental release of fumes or cross-contamination with acids or other reactive materials.
In synthesis, this compound often acts as a key intermediate for pharmaceuticals, especially those involving thiophene derivatives where biological activity relies on sulfur-nitrogen synergy. Specialty dye manufacturers and agrochemical innovators also tap into its unique structure for advanced molecules with selective properties. Having easy access to high-purity raw material enables research and production to move forward quickly, minimizing batch-to-batch variability and unexpected outcomes.
Concerns about thiophene-based compounds center around persistence in the environment and the risk of bioaccumulation. Proper waste management—through chemical neutralization and incineration—keeps this threat low. Facilities working with significant volumes must have protocols for spill control and emergency response. Tracking chemical inventories and training staff on the real risks and solutions makes a difference: safe workplaces and safer ecosystems.
