(S)-Pyrrolidine-2-Carboxamide stands out in the world of chemical raw materials due to its unmistakable structure and tangible properties. The compound features the core pyrrolidine ring, adopting the (S)-enantiomeric configuration that holds a significant impact on its reactivity, biological activity, and suitability within synthesis pathways. The compound’s amide group offers a specific anchor for further derivatization, making it appealing across multiple research and industrial applications, particularly in synthesizing pharmaceuticals or agrochemicals where stereochemistry matters. Its formula, C5H10N2O, reflects simplicity in backbone but a depth in potential.
This substance appears as a solid at room temperature. Depending on source and purity, it shows up as off-white or pale beige crystalline powder, and sometimes as colorless, glistening flakes. Its crystal structure preserves the conformational stability of the pyrrolidine ring, contributing to consistent melting and weighing results for labs measuring in grams up to multi-kilogram lots. The molecular weight sits at 114.15 g/mol, a helpful detail for any calculation in formulation or scaling up synthetic batches. With a density near 1.15 g/cm3, measuring and transferring this chemical rarely stirs up static or airborne residue. Handling it feels straightforward—well within the confines of most chemical protocols that keep workspace tidy and safe.
In practical settings, the solubility pattern becomes one of the crucial factors. (S)-Pyrrolidine-2-Carboxamide dissolves readily in polar solvents, including water and alcohols, though not all alcohols give the same rate; methanol and ethanol tend to work better than their longer-chain counterparts. This easy dissolution means working up solutions of precise molarity can be repeated without long waiting or excessive stirring, saving time. It does not show instability under standard laboratory conditions—both air and mild humidity do not degrade the sample over short periods. The melting point falls in the expected range for carboxamides, typically between 120°C and 130°C, though this can vary if impurities or solvent inclusion occur during crystallization. Appearance as flakes, powders, or pearls comes down to production method, with pearls often reserved for controlled delivery systems. Bulk material, packed and shipped worldwide, meets standard purity benchmarks—98% or higher suits both research work and scale-up process designers.
Anyone working with (S)-Pyrrolidine-2-Carboxamide gains from understanding more than its benefits; safety can never be an afterthought. It lands in the chemical safety category as a material to handle with routine caution. Skin and respiratory exposure must be avoided, not because immediate toxicity is high, but because reliable long-term data sometimes runs thin for specialized compounds. Gloves, goggles, and effective ventilation become non-negotiables. The compound does not ignite under gentle heating or mechanical shock, so explosion risks run low. Hazard classification depends on the intended jurisdiction, but most regions require a Safety Data Sheet, proper labeling with hazard pictograms (often the exclamation mark for irritant), and secure storage away from incompatible substances such as strong oxidizers. Eyes and sensitive membranes may become irritated on direct contact, so direct handling outside a fume hood never makes sense.
(S)-Pyrrolidine-2-Carboxamide carries real weight where chiral building blocks play critical roles—agrochemical intermediates, pharmaceutical design, and the development of specialty polymers frequently call on it. By anchoring this amide group to the (S)-enantiomer structure, chemists save time: racemic mixtures can prove expensive to resolve downstream. Enantioselective synthesis, research on enzyme inhibitors, and the search for greener synthetic routes all gain reliability through use of this raw material. In the lab, conversion to other functional groups, reduction, or cyclization opens opportunities for tuning reactivity or enhancing biological activity. This flexibility translates straight to cost savings and fewer synthetic byproducts, tightening compliance with increasingly strict environmental and industry guidelines.
The HS Code for (S)-Pyrrolidine-2-Carboxamide most often aligns with those for organic chemicals, particularly amine derivatives and carboxamides. Logistics teams, customs officials, and procurement officers depend on this number—usually falling near 2924.19. The documentation turns up repeatedly not just for safety but for tracking and taxation of raw chemical shipments. Density, as previously noted, makes it straightforward to measure in bulk or small containers. Packing in moisture-proof bags or HDPE bottles, with carton overpacks, keeps the product stable and uncompromised. Typical lot sizes range from a few grams for screening to multi-kilogram units for pilot-scale synthesis.
Understanding the physical and chemical profile of (S)-Pyrrolidine-2-Carboxamide bridges a gap between convenience in the lab and compliance on the supply chain. Distributors and end users both benefit from recognizing subtle differences in quality, particle size, or polymorph. To combat counterfeit or adulterated raw chemicals, regular batch testing and supplier verification provide the only shield. Labs and plants adopting cleaner technologies look for suppliers who already address safe packaging, transparent sourcing, and clear chain-of-custody records from synthesis right through delivery.
Handing off a bag of (S)-Pyrrolidine-2-Carboxamide rarely fails to remind one how much chemistry depends on reliable raw materials. Accurate weighing, ease of transfer, and consistent solubility count as basic expectations. Every project that uses this substance tells a different story—one lab may spin out medicinal chemistry libraries, another might seek a clean conversion to a different amide. Past missteps—such as solvents with moisture or cross-contaminated stock—turn into hard-learned lessons, reinforcing why sourcing detail matters as much as the purity printed on a COA. In planning new synthetic pathways, considering not just price but reproducibility, hazard class, and reliable availability sets up long-term research success. Supply chain challenges, especially for chiral raw materials, push teams to keep options open and maintain ongoing dialogue with manufacturers who adjust batches or packing forms for every changing regulatory or customer need.
