N-Benzyl Paroxetine Hydrochloride stands out as a specialized compound, valued across chemical and pharmaceutical spheres for its specific molecular structure and versatile chemical properties. Built on the classic paroxetine core, the addition of a benzyl group at the nitrogen creates a unique profile that scientists and engineers recognize right away. Presenting itself as a crystalline solid, this compound takes the form of a dense white powder and, in optimal storage, maintains remarkable stability. For companies dealing in materials at scale, everything from the form of this compound—solid, flake, or powder—to its HS Code (2934999099, in line with most complex organic compounds) sends a clear message about its intended uses and regulatory pathway.
The essence of N-Benzyl Paroxetine Hydrochloride lies within its tightly organized structure. With a molecular formula of C20H22ClNO2 and a weight that lands near 343.85 g/mol, anyone familiar with organic synthesis recognizes a structure built for both reactivity and selectivity. A benzyl group incorporates into a core that already carries therapeutic promise, providing additional functionality and potentially altering both binding and solubility characteristics. X-ray crystallography data confirm that this molecule crystallizes in a monoclinic system, its intermolecular hydrochloride salt bridging nitrogen and chloride, adding another layer to its unique chemical behavior.
N-Benzyl Paroxetine Hydrochloride usually presents as a white to off-white solid, often arriving in a powder or small flake format, occasionally pressed into crystalline pearls for ease of shipment and dosing. Under standard conditions, its density rests around 1.20–1.30 g/cm³, a touch heavier compared to related compounds, reflecting the addition of the benzyl ring and the chloride ion that stabilizes the salt. It resists melting up to 140—150°C, a threshold that defines how it handles both in storage and reaction conditions. Its solubility profile shifts depending on pH: quite soluble in polar solvents like water and methanol, limited in non-polar systems—-properties that shape every step of extraction, purification, and formulation.
In the lab, N-Benzyl Paroxetine Hydrochloride displays a clean profile, reacting predictably with electrophiles and staying stable against weak acids and bases at ambient temperatures. It remains chemically inert under atmospheric oxygen, avoiding the sort of troublesome oxidation that challenges less robust molecules. With its hydrochloride salt partnering, it can shed the proton in basic conditions, but rarely degrades outright—offering a shelf life exceeding three years under cool, dry storage. Molecular interactions, especially with amines and alcohols, characterize its behavior in multi-step synthesis, opening doors for more complex derivatization or drug candidate development.
Professional suppliers disclose tight control over N-Benzyl Paroxetine Hydrochloride’s purity: assays at 98% or higher prevail, with HPLC checking for related impurities and moisture analysis via Karl Fischer titration. Quality batches deliver particle sizes tailored for downstream formulation—typically between 100 and 300 microns. Synthesis generally draws on carefully-selected raw materials: commercial benzyl bromide, pharmaceutical-grade paroxetine, and anhydrous hydrochloric acid. Each precursor must meet strict purity standards, as any deviation undermines the stability and ultimate efficacy of the final material.
Every chemical professional remembers safety comes first, and N-Benzyl Paroxetine Hydrochloride is no exception. Direct contact with skin or eyes can irritate, so gloves, goggles, and dust masks are non-negotiable. At high concentrations, inhalation may trigger headaches, nausea, or mild CNS symptoms. Waste solutions demand collection as hazardous, with protocols for dilute hydrochloride solutions detailed in local disposal manuals. Material safety data sheets highlight that, despite its therapeutic lineage, it remains harmful if swallowed or absorbed, requiring good ventilation and fume hoods for any process using more than gram quantities. In accidental release scenarios, inert absorbent captures spills, while careful neutralization avoids any unwanted byproducts in the waste stream.
A professional warehouse treats N-Benzyl Paroxetine Hydrochloride with respect. Sealed, opaque containers protect from moisture and light— exposure degrades potency and can alter physical properties. Refrigerated storage, between 2–8°C, stretches shelf life and locks in physical features, preventing unwanted clumping or transformation into less-useful hydrates or byproducts. Experienced shippers align with UN recommendations, securing the material as a Class 6.1 toxic substance if above certain thresholds, complete with hazard labeling and temperature logs. Small quantities ship under exemption, but that never removes the responsibility for containment and incident documentation.
Medicinal chemists look to N-Benzyl Paroxetine Hydrochloride for both its established serotonin transporter affinity and as a scaffold for further modification in CNS research. Its structure underpins projects in antidepressant research, but its chemical traits open doors for use in the synthesis of new analogs, prodrugs, and screening molecules. Process engineers value the crystalline form and workable density, which simplify weighing and transfer in both bench and pilot-scale settings. Analytical chemists note its strong UV absorbance and clean chromatographic signature, making it an ideal candidate for purity testing and quantification.
Experience tells me the best approach to handling any hazardous raw material, N-Benzyl Paroxetine Hydrochloride included, is to design systems with redundancy and clear lines of accountability. Automated powder handlers reduce the possibility of dust inhalation and minimize operator exposure. Closed systems, from synthesis through to packaging, prevent environmental contamination. Investing in continuous monitoring of raw inputs—such as benzyl chloride and paroxetine—improves batch-to-batch consistency and prevents costly downstream reprocessing. For environmental protection, integrating on-site neutralization with robust filtration keeps any waste outflows far below regulatory limits. Permanent records of each batch’s properties—including density, melting point, assay values—help trace any problems right back to source, maintaining trust and scientific integrity across the supply chain.
