N-(4-Chlorobenzhydryl)Piperazine serves as a significant chemical ingredient in various scientific and industrial settings. In practical experience, laboratories and manufacturers call on this compound for its characteristic physical and reactive qualities. The chemical formula, C17H19ClN2, speaks to its structure, fusing a piperazine ring with a 4-chlorobenzhydryl group. The molecular weight stands at about 286.80 g/mol, which affects how it behaves in synthesis and formulation.
Most have dealt with N-(4-Chlorobenzhydryl)Piperazine as a solid, usually appearing as crystalline powder or flaky solid. It shifts from white to light beige, depending on the purity and conditions. The material presents a dense, tangible texture—if a pile of the powder sits in a weighing dish, it holds shape without flowing like finer particles, yet does not clump like moist granules. Its density, which averages close to 1.16 g/cm³ at room temperature, gives hands-on users a sense of predictability in measurement and mixing. Unlike more common raw materials such as sodium chloride, this compound absorbs little moisture, keeping stability in storage and in the weighing process. The melting point ranges between 221°C and 226°C, suggesting the molecule holds firm against moderate process heating, and will not liquefy during short-term exposure to elevated temperatures during common lab work.
A 4-chlorobenzhydryl group attached to a six-membered piperazine ring defines N-(4-Chlorobenzhydryl)Piperazine. Chemists notice the chlorine atom at the para-position on the benzene ring impacts electron distribution, which influences reactivity and selectivity in further transformations. Practical use finds the substance fairly unreactive to water, so accidental moisture during weighing or transfer seldom ruins a batch. Solubility in most organic solvents like ethanol and dichloromethane allows easy preparation of solutions, whether for chromatography, precipitation, or synthesis. The compound produces colorless, clear solutions when dissolved within recommended concentrations, so the clarity lets researchers spot impurities quickly.
Sourcing high-purity N-(4-Chlorobenzhydryl)Piperazine matters to outcomes in downstream synthesis. Specifications dictating a minimum purity, usually 98% or higher, support scientists aiming for reproducible reactions and reliable data. Manufacturers also specify particle size, typically less than 500 microns, which suits accurate dosing and smooth dissolution. Material labeled as “solid,” “powder,” or “crystalline” means the same standard shipment: a dry, free-flowing batch in a sealed drum or bottle, away from direct light and extreme temperatures.
This compound falls under the HS Code 2933.99, which covers heterocyclic compounds with nitrogen hetero-atoms. Global transport depends on compliance with this code. Most shippers ask for documentation verifying the non-pharmaceutical, non-food-use nature of the batch. Regulations also request manufacturers indicate any safety, hazard, and risk statements regarding health and environmental impact, aligning with both local and international guidelines.
Experience in the lab goes beyond theory—practitioners wearing gloves and safety goggles know to treat N-(4-Chlorobenzhydryl)Piperazine with respect. While not the most toxic among organic chemicals, it can cause irritating effects if inhaled or in contact with skin or eyes. Chronic exposure data remains inconclusive, so standard precautions make sense: store under a fume hood, avoid dust formation, and do not allow material to disperse in air. Material safety data sheets point out harmful characteristics, including possible irritation to mucous membranes and respiratory tract and potential harmful effects after long-term exposure. First-aid crews keep eye-wash stations and showers within short reach for these reasons.
The structure gives clues to how the molecule behaves and reacts. In N-(4-Chlorobenzhydryl)Piperazine, the two nitrogen atoms in the piperazine allow for further chemical substitutions, which underpins its value as a building block in synthesis. Along with the central, rigid benzhydryl group, the para-chlorine atom not only lends electronic effects but also shifts the compound’s interaction with acids, bases, and oxidizers. The melting point and boiling range both confirm its robust chemical bonding; the crystalline lattice formed in the solid state is tight and stable, as witnessed by the absence of decomposition in storage over months at ambient temperature.
Production of N-(4-Chlorobenzhydryl)Piperazine takes place from sources commonly found in organic synthesis labs. The benzhydryl chloride and piperazine rings get joined under controlled, inert atmospheres, giving chemists a reliable route to scale-up and replication. Quality auditors inspect the raw materials for contaminants, since trace side-products or leftover solvents can alter crystalline characteristics or color of the end product. The outcome after purification meets requirements for solution preparation—solid lumps break into powdery forms, and dissolving them in selected organic solvents produces batch solutions for bulk or research-grade uses. Close inspection after solution confirms the absence of residue or haze, a priority for analytical and synthesis tasks.
While suppliers may list several material forms—flakes, powder, pearls, or crystals—most buyers encounter the standard as a crystalline solid, which breaks easily into manageable powder. The crystal size and flake thickness result from the manufacturing and purification steps, and those handling large volumes learn quickly which format suits their dispensing habits. Pearls recognize a spherical, bead-like structure but are rare for this compound; most customers prefer powders or crystalline flakes for weighing and dissolving with simple spatulas or scoops. The term “solid” covers every form from fine, almost dusty powder to chunkier crystalline lumps, each with consistent density and reliable melting behavior. If a liquid version appears, it almost always means a concentrated solution in an organic solvent for specific chemical processes.
Volume metrics matter in shipping, storage, and large-batch reactions. N-(4-Chlorobenzhydryl)Piperazine’s density at 1.16 g/cm³ gives steady performance in volumetric flasks or bulk transport barrels, and most warehouse staff find it stacks well in standard-sized drums without shifting in transit. Specific gravity tracks closely with the density listed, which brings predictability to users matching weights to solution volumes. Lab teams preparing standard liter-based solutions for reaction setups appreciate the consistency batch after batch, even if the powder settles lightly during transfer.
On a practical level, N-(4-Chlorobenzhydryl)Piperazine provides essential chemistry as a raw material or intermediate, especially in research, pharmaceuticals (in jurisdictions where allowed), and fine chemical settings. Its unique combination of physical stability and reactivity in selected conditions gives process chemists and R&D techs the latitude to design and optimize routes for active and support molecules. Its reliability as a raw material, documented through consistent physical form and detailed property sheets, stands out when producing target compounds at research and pilot scales.
N-(4-Chlorobenzhydryl)Piperazine occasionally brings up issues in storage and transportation, mostly due to regulatory requirements. Improving labeling and safety documentation reassures both handlers and regulatory bodies, and advanced packaging—like sealed foil-lined drums—keeps product dry and pure even in humid climates. Training staff to respect safe chemical handling, just as everyone expects in modern labs, reduces risk of exposure and accident. Industry-wide, moving toward digital barcodes and batch-level tracking improves traceability from source to lab bench or factory floor. Regular review of safety sheets, along with real-time feedback from users in manufacturing, can bridge the gap between regulatory rigor and practical safety.
