L-(Pyrrolidin-1-Yl)Methanol stands as a specialized organic compound with the molecular formula C5H11NO, featuring a unique structure that brings together a pyrrolidine ring attached directly to a methanol group. Its structure follows the classic five-membered nitrogen heterocycle, allowing this compound to interact with other chemicals in predictable and purposeful ways. The alcohol group branches off the nitrogen-containing ring, contributing specific reactivity that can suit a range of roles in chemical manufacturing and pharmaceutical industries. As a raw material, it goes into syntheses that demand defined stereochemistry and reliable functional groups, serving as both intermediate and active component, depending on the application.
This compound appears in several forms, all dictated by its purity and storage conditions. As a pure solid, L-(Pyrrolidin-1-Yl)Methanol generally shows as white to off-white flakes, or as microcrystalline powder. In its crystalline state, crystalline facets are visible on close inspection, confirming the material’s purity. Some suppliers may offer it in pearl form; dense, bead-like particles allow easier pouring and handling. On rare occasions, a viscous liquid phase can emerge, especially if trace impurities or water gets involved. Whatever the physical state, density ranges between 1.02 and 1.06 g/cm³, pointing to its substantial nature compared with more volatile alcohols.
With a molecular formula of C5H11NO and a molar mass of about 101.15 g/mol, L-(Pyrrolidin-1-Yl)Methanol combines predictable aliphatic and heterocyclic features. The hydroxymethyl group attaches itself to the nitrogen atom of the pyrrolidine ring, making the molecule accessible for hydrogen bonding. Its configuration fosters reliable participation in substitution and condensation reactions, serving as precursor to derivatives, active pharmaceutical ingredients, or as a chiral auxiliary. The solid form remains stable under ordinary storage conditions, but traces of moisture can shift the balance, so air-tight containers preserve quality best.
Standard specifications involve purity greater than 98%, measured by HPLC, and water content under 0.5%. Particle size can vary by supplier, but is typically kept within fine powder dimensions for even weighing and solution preparation. Flakes, pearls, and crystal forms often reference sieve standards, offering a degree of granularity selection for industrial use. Certain users request bulk packaging in HDPE drums or custom glass containers, aiming to prevent static charge buildup. Batch traceability and production records often support quality assurance claims, particularly in regulated pharmaceutical settings.
International trade for this material usually falls under the HS Code 2933.59.99, referencing heterocyclic compounds with nitrogen hetero-atom(s) only. This classification details its controlled movement across borders, and prices reflect both chemical grade and market demand. Depending on origin and shipping regulations, L-(Pyrrolidin-1-Yl)Methanol either moves as a hazardous chemical or is bundled with other secondary amines for regulatory compliance. Documentation follows strict standards, with material safety data sheets and certificate of analysis requirements set by both domestic and international authorities.
While L-(Pyrrolidin-1-Yl)Methanol provides utility in chemical processes, conscientious handling protects users from the risk of respiratory or skin irritation, especially in fine powder or crystal forms. Contact with eyes may result in acute irritation owing to the alcohol group’s reactivity. Industry guidelines recommend nitrile gloves, splash goggles, and, for large-scale handling, full-face respirators. Inhalation of dust over repeated exposures could stress the respiratory tract; medical literature links chronic exposure to central nervous system effects, emphasizing the need for local exhaust ventilation. The material’s flash point sits over 100°C, so normal laboratory storage stays well below ignition risk, but open flames or strong oxidizers should stay clear of the workspace. Dispose residue as chemical waste, not down the drain, since it holds the potential to disrupt water chemistry. Environmental stewardship requires closed-loop solvent collection and informed waste contractor support.
Chemical manufacturers often draw on L-(Pyrrolidin-1-Yl)Methanol as a starting material for custom synthesis, where its unique blend of reactivity and stereochemical orientation supports patented products and innovative intermediates. Its presence in finished pharmaceuticals, organic synthesis protocols, and materials research echoes across sectors. Process chemists value its role in nitrogen introduction without the complications associated with primary amines. The compound’s long shelf life, provided proper storage, means that users can plan large-scale processes without frequent reorder cycles. Quality assurance labs track each lot, ensuring no cross-contamination or degradation, thereby protecting downstream applications such as API manufacture or advanced material development.
L-(Pyrrolidin-1-Yl)Methanol dissolves readily in common organic solvents such as ethanol, methanol, and dichloromethane; aqueous solubility remains moderate. Typical solution concentrations run between 0.5 and 2.0 mol/L in research and pilot plant applications. Stock solutions hold stability under cold, dark storage, provided containers remain tightly sealed. Bulk purchases for kilo-lab or pilot plant operations should include spill containment precautions, since even a few liters pose risk if released in confined laboratory settings. Trained employees handle transfer with ground-bonded equipment to prevent static discharge, especially during dry winter months or in low-humidity climates.
Responsible suppliers test each batch by chromatography and spectrometry to guarantee chemical fingerprint and absence of impurities. Routine sampling checks ensure moisture content stays within specification, preserving both chemical properties and crystalline appearance. For each shipment, Certificate of Analysis confirms compliance with pharmacopoeial or industrial standards. Safety data appears transparent, with clearly labeled primary bottles or drums, enabling even new users to quickly find hazard ratings or emergency procedure guides. Material tracking underpins responsible use and end-of-life disposal, harmonizing safety with efficient chemical management.
