Methyl 2-Aminothiazole-4-Carboxylate shows up as an organic compound that stirs interest across labs and industries. Its usefulness doesn’t stem from hype but from solid chemistry and adaptability. Folks who’ve worked with thiazole derivatives recognize this material: it builds foundations for synthesizing many bioactive molecules, dyes, and fine chemicals. The structure packs a methyl ester group connected at the fourth position of a thiazole ring, with an amino group fixed at the second position. This compound doesn’t float on trends—it sticks because of its structure and reactivity.
On a bench or warehouse shelf, Methyl 2-Aminothiazole-4-Carboxylate presents as a solid—flakes, fine powder, or sometimes crystals, depending on the supplier and storage. Glancing at the substance, the off-white or pale yellow tint stands out. Handling it, you feel the density: it doesn’t behave as a featherweight, but it’s manageable for weighing and transfer. Density sits around 1.45 g/cm³. You don’t see liquid or pearl forms in the lab since it holds its solid state comfortably at room temperature.
The molecular formula reads as C5H6N2O2S, tallying up to a molecular weight of around 158.18 g/mol. That thiazole ring packs nitrogen and sulfur atoms, which change how the molecule reacts compared to plain carbons in a benzene ring. Chemical structure matters here; the methyl group attached to the carboxylate (COOCH3) makes this molecule great for ester hydrolysis reactions or as a scaffold for building more complex molecules. Reactions can target the amino or the ester positions, giving researchers flexibility to create new compounds.
Talking trade and international movement means talking about HS Codes. Methyl 2-Aminothiazole-4-Carboxylate falls under the HS Code 293499, a spot reserved for thiazole derivatives and other heterocyclic compounds with nitrogen atoms. This matters if you’re importing or exporting; paperwork needs accuracy to avoid hold-ups at customs and confusion about tariffs or permissions.
Anytime you interact with organic chemicals, safety sticks in your mind. Methyl 2-Aminothiazole-4-Carboxylate requires gloves, eye protection, and a working fume hood—standard rules in practical chemistry, but worth repeating. It carries warning labels for eye, skin, and respiratory irritation. Some users experience mild allergic responses; I’ve seen colleagues with slight skin irritation after careless contact. Hazard class doesn’t rank at the top, but smart storage in sealed containers and handling with respect means fewer accidents and no ruined afternoons. It doesn’t behave like highly flammable or explosive substances, though dry environments and controlled temperatures prevent clumping and degrade.
This compound pops up everywhere in levels of chemical synthesis—from academic projects on new antibiotics, to industrial runs aiming for pharmaceutical intermediates. Chemists recognize its value as a starting point for sulfa drugs and agricultural chemicals. The blend of amino and ester groups opens doors: modifications at either site roll out whole families of functional materials. It’s not just about raw production either—using a well-characterized and pure starting material means end products meet tighter specs and regulators have fewer issues with compliance.
Suppliers list purity from 97% up to 99.5%, checked by HPLC or NMR. Melting points fall around 135°–139°C, again confirming identity if you ever need to double-check what you’ve got. Moisture content needs to stay low since the ester group can slowly hydrolyze in wet air, changing the batch and lowering reliability. For labs needing set concentrations, it dissolves in methanol, ethanol, and DMSO. Solution prep for bioassays or screening happens at 10 mg/mL in DMSO most days, though higher concentrations cause clumping.
Looking out for harm matters in today’s regulatory world. Handling waste with this ingredient means following typical organic disposal methods, but it shouldn’t head down the drain. It breaks down slowly in the environment, so collect and treat residues as chemical waste. No evidence suggests acute toxicity at low exposures, but long-term data stay lacking, so prudent containment helps keep surprises off your desk and regulators out of your inbox.
