Climbazole shows up in a range of personal care lines, most known for its role in anti-dandruff shampoos and skincare. The white crystalline solid stands as an imidazole derivative, carrying the molecular formula C15H17ClN2O2. The compound usually appears in the form of fine powder or small white flakes, dissolving more freely in alcohols than water. Industry often references Climbazole’s CAS Number 38083-17-9 on supply manifests, marking lots for traceability. Manufacturers in the cosmetics field rely on its antifungal power, mainly for its ability to battle the Malassezia species linked to dandruff and seborrheic dermatitis.
Climbazole carries a molecular weight of 292.76 g/mol. Density typically falls near 1.22 g/cm³ at room temperature. At a glance, you’ll spot pure Climbazole as a solid, though it processes well into creams, powders, or even micro-pearl suspensions for various uses. The structure roots in the imidazole ring, matched with a monochlorinated phenoxy group, raising both lipophilicity and skin permeability. Melting point rests around 96-99°C. Its stability in storage and formulation points toward a favored place in ingredient cabinets. Because it resists quick breakdown, this stability stretches shelf life, important for finished products traveling worldwide.
Raw Climbazole targets several key product lines. Shampoo blenders count on its effectiveness at concentrations between 0.5% and 2%, following regulatory guidelines across the globe. In cream bases or talc-like powders, it disperses neatly and keeps its look, helping companies meet demand for clear, non-staining personal care. Climbazole partners with common excipients like glycerin, ethanol, and polymers to create solutions that feel light on hair and skin. With the raw powder or pearl granules, processing lines avoid sticky or hydroscopic problems, making Climbazole a steady pick for continuous manufacturing. Some factories choose the liquid concentrate for quick batching, crediting its ease of dosing and straightforward blending in large tanks.
People asking about safety find that Climbazole sits outside the class of highly hazardous substances at the concentrations used in cosmetics. Still, any raw chemical needs a practiced approach in the factory. Handling the powder form, wearing appropriate gloves, goggles, and dust masks remains best practice, cutting down on inhalation and skin contact risks. Occasional reports underline minor skin irritation when formulas run strong, so finished products stick within well-studied thresholds to steer clear of harm. Climbazole does not fit under the known carcinogen lists, but anyone with allergies to imidazoles should avoid direct exposure. Environmental teams at manufacturing plants will watch for local safety data sheets (SDS) and waste management standards to catch accidental spills before runoff enters water systems.
HS Code 2933299090 identifies Climbazole as an organic compound in global trade, moving through international customs under the guidelines for specialty chemicals. Its purity grade for cosmetic work needs to sit above 98% by HPLC, traced by batch certificates and third-party lab checks. Granular or pearl forms range from 0.2 mm to 3 mm in diameter, fitting various dispersal processes. Dissolved in ethanol or propylene glycol, Climbazole creates stable premixes, allowing scale-up from pilot projects to batch runs over ten thousand liters. Finished product makers benefit from shelf-stable raw materials that resist clumping and color change over time, meaning less scrap and fewer batch adjustments down the line. Some labs look for low-odor grades, supporting fragrance-free claims, and color matches on the white spectrum for sensitive skin or hypoallergenic lines.
Molecular structure puts the core imidazole ring at the center. The monoclinic crystal system reflects in X-ray tests, producing powder diffraction data used during quality assurance. The presence of the chlorinated phenoxy group controls the antifungal mode of action, disrupting ergosterol synthesis on the microbial cell membrane. Double-checking optical rotation and refractive index helps detect rogue batches. Routine spectra using FTIR and NMR confirm raw material identity for every shipment. Chemists also keep tabs on solubility—roughly 42 mg/L in pure water—so most real-world formulas call for solvents or surfactants to drive dispersion. With a logP value near 2.9, Climbazole balances between oil and water phases, a point that helps design leave-on emulsions and rinse-off washes.
Regulators in the EU and Asia cap the amount of Climbazole in leave-on and rinse-off products, driving safe finished formulas and clear consumer directions. Testing for impurities like dioxane, chlorinated byproducts, and solvents pulls from published monographs. Factories investing in green chemistry practices look for bulk suppliers who can prove not only identity but also minimized waste in upstream processing. Downstream, waste streams need controlled disposal, mostly through incineration or advanced treatment to stop traces entering city water. The low aquatic toxicity at use levels comforts both environmentalists and regulators, with ongoing studies to confirm safety as demand increases. Manufacturers watching supply chain risks keep multiple sources certified under ISO and GMP for reliable deliveries and product recalls, if needed, to build lasting trust in their brands.
Understanding Climbazole goes beyond the chemistry. Long-term use in consumer products shows both the need for science-based safety and transparent processes. Tracing each lot, following regional regulations, sticking to laboratory benchmarks, and keeping worker safety front and center—it all comes together to keep products both safe and effective. When someone picks up a shampoo promising to tackle dandruff, few stop to wonder about the science behind the white powder inside. For those in the business, every property, every molecule, counts toward the final result. Climbazole isn’t just a name in a formula. It represents years of testing, compliance, and thoughtful selection—bringing efficacy and assurance to people around the world.
