Clemizole Hydrochloride is a well-known histamine H1 receptor antagonist, classified within the larger group of antihistamine compounds. Clinically, the compound has served as a foundation for research into both allergy relief and new therapeutic applications. Used since the 1950s, it sits among the earliest modern antihistamines developed for oral administration, so it occupies a special place among those searching for time-tested solutions in pharmacology. Regulatory bodies across the world have assigned it the HS Code 2933399090, which reflects its use as a pharmaceutical raw material. In everyday handling, Clemizole Hydrochloride appears as a solid, with variations in form including fine flakes, crystalline powder, and sometimes small pearls. I remember early chemistry classes where solid crystals stood out as reliable, measurable, and easier to store than unpredictable liquids, especially for safety and repeatability in simple lab setups.
The molecular structure of Clemizole Hydrochloride is rooted in an imidazobenzothiazole ring system, joined to a p-chlorophenylmethyl group. Its formula stands as C19H20ClN3S·HCl, pointing to a combination of carbon, hydrogen, nitrogen, sulfur, and chlorine in specific proportions. The molecular weight reaches 380.37 g/mol, making it manageable for weighing or compounding in both small-scale and bulk applications. Anyone working in a laboratory or production facility understands the convenience of working with a stable molecule whose weight and structure enable accurate measurements or mixing without complicated conversions or volatility. Its specific gravity or density has readings of roughly 1.28 g/cm³ at room temperature, setting it apart from lightweight powders and denser resin-like chemicals. The white to off-white crystalline appearance signals purity, a visual cue seasoned lab users rely on before they even reach for an analytical balance or run chromatographic tests.
Clemizole Hydrochloride remains solid under normal room conditions, with true melting typically in the range of 220–225°C. Its water solubility registers as moderate, and solutions prepared in ethanol or methanol clarify rapidly, which counts when preparing samples for analytical or synthetic purposes. The crystals do not clump easily and handle with minimal dusting, so risk of accidental inhalation or airborne contamination drops compared to ultra-fine powders. In my own work, I chose crystalline materials like this over amorphous ones for consistency. When choosing raw materials, consistent shape and size mean fewer headaches in production, better performance in tablet pressing or capsule filling, and fewer surprises during pharmaceutical analysis. Clemizole Hydrochloride neither absorbs much water nor oxidizes quickly at ambient air, reducing the need for desiccants or special gas-purged storage.
Clemizole Hydrochloride finds main use in pharmaceutical formulations, thanks to its antihistamine effect. Researchers have expanded its value, investigating antiviral and anti-inflammatory properties, sometimes in neurological studies. Its regular form—flakes, powder, or crystals—lends itself to simple bottle packaging, easy scooping, and straightforward weighing. Compounded into solutions, it lanes into syrups, oral suspensions, or injectable formulations. As with many active ingredients, Clemizole Hydrochloride qualifies as hazardous: the dust can irritate the mucous membranes, so lab workers wear masks and gloves to avoid inhalation and skin exposure. At sufficiently high doses, animal studies found central nervous system and cardiovascular effects, demanding respect for occupational safety. Rarely do manufacturers use Clemizole Hydrochloride in other industries; its role as a raw material stays firmly in the pharmaceutical sector.
Storing Clemizole Hydrochloride relies on sealed containers, kept away from light and direct heat, and always labeled to follow chemical regulations. Over decades, best practice has called for dedicated shelving, spill kits nearby, and clear standard operating procedures for both normal use and emergencies. Disposal typically means collecting waste in special containers for hazardous substances; no scientist ignores this, because accidental spills near drains spell trouble for aquatic life and water sources. The Material Safety Data Sheet identifies eye and respiratory tract irritation as the top concerns, in addition to a risk for those with chronic skin allergies. Anyone who’s swept up a fine pharmaceutical powder and underestimated static cling learns quickly that contamination or accidental release can impact colleagues and nearby workspaces. Supporting responsible use, regulatory agencies demand traceability and full documentation.
High-purity Clemizole Hydrochloride features a minimum assay above 98.0%, often confirmed with HPLC and melting point checks. Impurities—residual solvents, heavy metals, or organic byproducts—get listed in Certificates of Analysis and dictate which lots pass most quality audits. The pharma world values such transparency, which in my experience reinforces trust between suppliers and end-users. Though research into novel applications continues, established guidelines direct handling, distribution, and sale. International freight follows HS Code rules, requiring thorough documentation on all shipments, which customs officers or importers frequently cross-check.
Lab managers, pharmaceutical companies, and logistics handlers all share responsibility for managing Clemizole Hydrochloride safely. Engineering controls like fume hoods, personal protective equipment, careful transfer protocols, closed waste collection containers, and regular employee training head off most accidental exposures. Companies investing in automation of powder handling find they improve both productivity and safety, avoiding dust clouds that standard scooping might create. In the field, experienced chemists foster a culture of respect for chemicals, reviewing new safety data and staying current with international regulations. Waste minimization, secondary containment for spills, and periodic environmental monitoring back up these efforts. Listening to experienced colleagues or regulatory inspectors helps root out bad habits and raise the standard for everyday practice.
