6-Methoxybenzothiazol-2-ylamine belongs to the benzothiazole family, blending aromatic complexity with reactivity. The compound presents itself as a solid in most laboratory and industrial setups, often showing up as light tan or off-white flakes, powder, or crystalline material. Handling this compound tells you a lot about how the presence of the methoxy group modifies both the reactivity and application landscape. Often sought after for its performance as a chemical intermediate, 6-Methoxybenzothiazol-2-ylamine pops up in everything from analytical reagents to pharmaceutical research.
The journey starts with raw materials and ends up enhancing specialty chemicals. 6-Methoxybenzothiazol-2-ylamine steps up in organic synthesis, contributing to creating dyes, pharmaceuticals, and biologically active molecules. You can trace it in labs mixing up heterocyclic compounds and even in pigment manufacturing. Chemists count on its backbone for further functionalization and scaffold building, opening up research tools otherwise unavailable. From my experience in synthetic chemistry labs, the ability to introduce a methoxy group on the benzothiazole ring brings out new binding sites for development, expanding what we thought possible about this class of compounds.
The structure centers on a fused benzene and thiazole ring, sprouting a methoxy group on the sixth position and an amine on the two-carbon of the thiazole. This precise molecular architecture shapes both its reactivity and solubility edge. Its molecular formula reads as C8H8N2OS, with a molar mass close to 180.23 grams per mole. The molecule does not dissolve well in water but finds better compatibility with organic solvents like ethanol, acetone, or dichloromethane. The density varies with the particle form, but in crystal structure, expect a value hovering around the 1.3 gram per cubic centimeter mark. The melting point offers a practical checkpoint—typically ranging between 140-145°C—which helps to confirm purity and predict processing steps. Specifications for laboratory use demand high assay percentages, low moisture content, and no visible contaminants. For supply, you can find it as powder, small crystals, or flakes, each form tailored to the process or equipment it feeds into.
Skillful handling of 6-Methoxybenzothiazol-2-ylamine hinges upon its physical properties. The compound can exhibit a slight odor, not overpowering but certainly telling you it’s present. In packed forms, it resists caking and blends into solutions under gentle stirring. The methoxy and amine groups change the polarity, giving it more flexibility in solvent systems compared to unsubstituted benzothiazoles. Powdered forms disperse evenly, while pearls or flakes offer slower dissolution but safer handling for scale-up. Its crystalline nature enables precise weighing, reducing dosing errors—a small but important detail for consistency in synthesis or formulation.
Solid state density sits just above average for aromatic heterocycles, translating well for bulk storage and calculating reagent loads. If you dissolve it, you must choose solvents with matching polarity and low reactivity, as the amine function might interact with acidic or electrophilic partners. Solutions must be freshly prepared because lingering over time, especially in the presence of air or moisture, degrades the amine functionality, which changes how it behaves during reactions. In analytical work, you often spot a faint yellow color in solution, a subtle marker of its purity and proper handling.
Anyone looking to ship 6-Methoxybenzothiazol-2-ylamine across borders needs the correct HS code for smooth customs clearance. The compound often falls under the generic class of benzothiazole derivatives, specifically covered in HS Code categories like 2934.99, detailing heterocyclic compounds with nitrogen hetero-atoms. Accurate coding isn’t just paperwork; it’s a safeguard for importers, exporters, and end-users. Shipping requirements tighten further if the consignment exceeds kilogram-range lots or goes towards regulated applications.
Chemists, process operators, and warehouse teams all have a stake in safety. 6-Methoxybenzothiazol-2-ylamine, while not the most hazardous material on site, brings its risks. Prolonged skin exposure or inhalation of dust can cause irritation, and material safety data sheets recommend gloves, goggles, and good local ventilation. Accidental spills pose cleanup issues: powder can get airborne quickly, and the amine can react with oxidizing agents, so you always store it with compatible segregations. Toxicological data often remain incomplete for rare intermediates, but early studies suggest moderate hazard, advising against ingestion, inhalation of dust, or eye contact. Disposal routes follow standard chemical waste streams—never down the drain, always into clearly labeled, dedicated waste containers. Safe handling gets embedded into protocols by default, especially considering downstream effects if raw materials hit an unintended process.
6-Methoxybenzothiazol-2-ylamine carries the formula C8H8N2OS, density just above 1.3 g/cm³, melting in the mid-140s Celsius, and appears as crystal, powder, or flakes. Key properties—low water solubility, aromatic odor, crystal structure—define much of its storage, handling, and processing profile. Applications stretch from research-scale chemistry into early-stage pharmaceutical scaffolding and specialty pigment production. Safety depends on diligent use of personal protective gear and recognition that incomplete toxicology brings extra caution. Registered under HS Code 2934.99, it requires careful import/export planning. As a raw material, it carries expectations to deliver consistency—batch after batch—because even minor impurity swings can derail downstream syntheses or analytical work.
