4-Piperidylmethylamine stands out in chemical synthesis for its core structure—a six-membered piperidine ring carrying a methylamine group at the fourth position. This compound holds C6H14N2 as its molecular formula, with a molecular weight of 114.19 g/mol. In practical work, the solid presents as either flakes or powder, sometimes forming tiny crystals, and can transform into a clear, colorless to pale liquid depending on storage and temperature conditions. Handling samples in solution also increases flexibility in both research and industrial applications, so suppliers sometimes offer liter volumes of carefully prepared solutes. Over the years, chemists have counted on the piperidine skeleton for its stability as a building block, especially in pharmaceuticals and materials science. For customs, the HS Code for 4-Piperidylmethylamine most often aligns with typical amines, usually in subheading 2921.39, though local requirements may vary.
4-Piperidylmethylamine puts its versatility on display as either a high-purity solid or a viscous liquid, often colorless and tending toward slight yellow with age or in certain solvents. Researchers usually see a melting point ranging widely depending on purity and form—flakes and pearls transition around 50–60°C, while powder and crystals require more exact methods but typically fall in the same vicinity. Its density comes in close to 0.97–1.02 g/cm3 at room temperature, which matches personal lab experience handling related heterocyclic amines. Solubility favors water and common polar solvents, letting scientists dissolve the raw material for preparative reactions, purification, or further modification. The structure brings a primary amine right off the ring, opening doors to reductive amination, condensation, or addition to other reactive intermediates—this makes 4-Piperidylmethylamine a staple in drug development and complex organic synthesis. The chemical backbone keeps the basicity high, with the nitrogen lone pairs contributing to nucleophilic activity.
Demand for 4-Piperidylmethylamine comes mostly from the pharmaceutical and specialty chemical industries. The compound routinely acts as a precursor in the synthesis of more advanced heterocycles, often surfacing in antihistamines, antipsychotic drug scaffolds, or custom agrochemical chemistry. Working in collaborative projects, I’ve seen it used as a polymer additive to adjust mechanical properties, benefiting coatings and engineered materials. The consistent property profile across flakes, pearls, and powder forms ensures process control. High purity grades matter for regulatory approval, which remains a top concern for buyers seeking certified raw materials, especially in regulated sectors. Specifications usually detail moisture content, residual solvents, heavy metals, and byproduct levels, reflecting industry focus on trace impurities. Suppliers provide certificates matching analytical HPLC and GC data, ensuring every shipment meets tight standards.
Working directly with 4-Piperidylmethylamine, attention to safe handling never leaves the mind. According to available safety data sheets and personal experience with related amines, this material requires gloves, eye protection, and lab coats in every setting—liquids or dust can irritate skin, eyes, and respiratory membranes. Ventilation always matters, as inhalation of the vapor or powder could cause headaches or nausea, especially in confined spaces. Chemical compatibility includes keeping containers tightly sealed away from acids, strong oxidizers, and direct sunlight. For disposal, adhering to local hazardous waste regulations protects both workers and the environment. Accidental spills must get cleaned up with absorbent material and never go directly down the drain; bagging and labeling as hazardous closes the loop on safety best practices. Chronic exposure could risk more pronounced harm involving liver or kidney stress, so limiting contact time with improved PPE and fume hoods is worth the investment. Accurate labeling, detailed training, and compliance with GHS symbol requirements round out any proper risk mitigation plan.
The structure of 4-Piperidylmethylamine centers on a saturated nitrogen-ring backbone. Analytical chemists reference spectral data—like proton NMR and mass spectrometry—to identify ring hydrogens and confirm the methylamine branching at position four. Crystallography sometimes reveals more about molecular packing, especially in research focused on material science or pharmacological interactions. Purity analysis involves titrimetric determination of nitrogen content along with residue testing, ensuring no harmful byproducts from synthesis routes. Standard storage occurs at 2–8°C in desiccated, airtight bottles, whether you're keeping bulk raw material, half-liter sample solution, or finished powder in the chemical storeroom. The crystalline form brings its own benefits—well-defined melting points, easy handling, and reduced risk of static accumulation when measuring precise quantities for reaction flasks.
4-Piperidylmethylamine continues to earn its place as essential raw material in labs and production facilities around the world. Its structure supports innovation in medicinal chemistry, polymer research, and advanced intermediates. Balancing purity, safety, and reliable physical properties remains a constant goal. Many professionals focus on sustainable sourcing and waste reduction by optimizing reaction pathways that use or create piperidine derivatives. Continued transparency with safety and regulatory compliance ensures this compound supports safe growth in chemical technology and pharmaceuticals going forward. For companies looking to develop new drugs, specialty coatings, or engineered resins, understanding every facet—from the density of the crystalline solid to the hazards of powder exposure—centers decision-making on solid ground. Broad knowledge about 4-Piperidylmethylamine aligns with the highest expectations of expertise, accuracy, and trust in chemical science.
