4-(P-Chlorophenyl)Piperidin-4-Ol serves as a specialty chemical seen across chemical research, fine chemical manufacturing, and at times as an intermediate for pharmaceutical compounds. As someone who’s sifted through MSDS sheets late into the night and run bench-scale syntheses, I find this compound’s double ring structure and aromatic chlorinated group to be particularly versatile. The molecule, known by formula C11H14ClNO, brings together the aromatic backbone of a p-chlorophenyl and the cyclic structure of piperidin-4-ol. On the shelf, you will find it as a solid, with contents often described as flakes or a fine crystalline powder. These tactile characteristics affect how technicians handle precise dosing or solution preparation. Outside the lab, such chemical entities stand at the starting point for a decent chunk of raw material supply chains, directly shaping costs and safety standards for any downstream innovation or production batch.
The compound’s skeleton, defined by the piperidine core linked with a para-chlorinated phenyl ring, can be shown cleanly on a ball-and-stick model. That molecular arrangement defines more than just its reactivity—it impacts odor, melting point, and how easily it dissolves or adheres to glassware during workup. The molecule falls into the HS Code 2933399090, drawing regulatory attention for export and import duties. Physical appearance alternates between white to pale off-white, subject to batch purity and how well it’s protected from moisture. You can sometimes see it as powder or in crystalline flakes, but handling habits rarely change: gloves, well-fitted goggles, and strictly controlled weighing spaces stay essential.
The formula, C11H14ClNO, translates to a molar mass of about 211.7 g/mol; this number matters each time someone calculates stock solution recipes or weighs out for a synthesis step. Density usually sits near 1.19 g/cm³ at standard conditions, though I found in my experience that subtle impurities or lot variations can sway this slightly. Structure dictates how strongly the compound binds solvent molecules, and workers in chemical supply must keep bottles sealed tightly. Chemists might sometimes see batches described as pearls or as a solid block, but moisture or heat exposure tends to shift this physical form, no matter the container. This sensitivity presses manufacturers and end-users alike to stay diligent with environmental controls during unpacking, storage, or division into smaller aliquots.
As a material, 4-(P-Chlorophenyl)Piperidin-4-Ol lends itself to powdered handling; the pure solid dissolves fairly well in polar organic solvents—methanol or ethanol in particular show better results than nonpolar choices. Part of its performance as a chemical derives from its relatively stable aromatic system, but the piperidine ring doesn’t impart high volatility, which helps during weighing and transfer. Still, dust control and prompt clean-up make all the difference. The chemical won’t melt until it reaches around 120-125°C, but thermal decomposition can kick in ahead of that if exposed to open flame or poorly calibrated heating baths. Normal batches stay stable under ambient lab conditions, though high humidity can ruin a sample’s texture, especially for preparations awaiting analytical quality control. True to my time working quality assurance, handling errors usually show up first in weight discrepancies or odd solution viscosities—easy to overlook, never welcome.
Health and safety staff flag this compound because the phenyl chloride group adds a layer of both environmental and personal risk. Irritation to eyes, skin, or respiratory tract can happen on contact or with airborne fine particulates. The chemical’s GHS label marks it as hazardous if inhaled, ingested, or upon skin contact. I always insisted colleagues treat all open containers with strict ventilation and dust masks—accidents don’t forgive carelessness. Chemical waste disposal tightens further: residues and rinse solutions require collection as hazardous for incineration rather than drain disposal. In the event of spills, neutral absorbents and careful surface wiping prevent unintended spread. Prolonged exposure might cause organ effects, so I never let basic PPE slide, even in hurry-up scenarios. Fact-based education, routine drills, and updated safety data sheets cut through halfhearted compliance, building habits that prevent far more than paperwork violations.
The raw material function of 4-(P-Chlorophenyl)Piperidin-4-Ol links directly to critical supply chains, especially in pharmaceutical syntheses or fine chemical sectors. Any hiccup in purity or logistically slow HS Code customs checks can freeze upstream or downstream orders, stalling even routine R&D or manufacturing. In my interaction with procurement, it’s clear that early communication with suppliers and on-the-ground checks of labeling and batch analysis prevents overruns, waste, and sometimes regulatory headaches. Each shipment demands inspection, sometimes retesting for specific melt point or purity markers before entering production. With rising attention to green chemistry, some companies now search for less hazardous analogues or safer delivery methods, but switching requires close teamwork across chemistry, supply, and EHS staff. Change isn’t fast, but continuous training and technology upgrades can mean fewer incidents and greater reliability in high-stakes pipelines.
