4-(4-Iodo-1H-Pyrazol-1-Yl)Piperidine stands out as a specialty molecule shaped by the careful union of a piperidine ring and a pyrazole group featuring an iodine atom at the fourth position. This structure leads to a compound often found at the raw material stage in pharmaceutical synthesis, especially where bioactivity and molecular complexity matter. Its chemical formula, C8H12IN3, directly links to a molecular weight of 273.11 g/mol, giving a clear sense of what processes it enters and how it behaves during transformation. Many labs choose this compound for its distinctive characteristics born from both structure and chemical reactivity, not simply because of the iodine but through the interaction of both rings with functional groups during each reaction.
This compound generally appears as an off-white to pale yellow solid if handled under standard laboratory conditions. In my work with similar heterocycles, the density and the crystalline nature of these materials make them easy to stock and transfer between containers—whether as fine flakes or as compact powders. Its crystalline habit may shift slightly with hygroscopicity variation, though it usually maintains structural integrity across a standard range of temperatures. Water solubility tends to remain low; organic solvents may dissolve it more readily, which aligns with typical synthetic and preparative protocols.
By observing melting point behavior, practitioners often notice transition temperatures in the range of 100–150°C, based on packing efficiency of the compound in bulk state. Its specific gravity remains consistent with expectations for a halogen-substituted piperidine—densities cluster around 1.7–2.0 g/cm³. In my experience, this weight affects both packaging and mixing tasks, so users tend toward glass or high-density polymer storage bottles. I have handled similar iodo compounds, and gloves plus eye protection just make sense given the known risks associated with iodine organics.
Looking at the architecture of 4-(4-Iodo-1H-Pyrazol-1-Yl)Piperidine, its backbone offers two saturated and unsaturated nitrogen heterocycles. That combination sits at a crossroads of stability and reactivity. The iodine group at the fourth pyrazole position brings substantial weight and a gateway for substitution, allowing chemists to perform cross-coupling or radiolabelling with high selectivity. Such a setup usually lifts the compound into more specialized chemical research or drug development pathways.
Examining reactivity shows that the iodine influences electron density across the molecule. In synthetic procedures, I pay close attention to this when considering reactions like Suzuki or Sonogashira couplings. The broad compatibility with different building blocks comes in part from how the pyrazole and piperidine favors both aqueous and non-aqueous media depending on the downstream application.
4-(4-Iodo-1H-Pyrazol-1-Yl)Piperidine remains accessible in forms from small, shiny crystals to granular flakes or finely divided powders. Suppliers might also offer it in solution, dissolved in acetonitrile or DMSO, a format that eliminates some handling steps but brings new storage concerns. From my vantage point, powder handling calls for a dust mask and good ventilation—these organoiodo substances don’t release heavy fumes like some others, but their dusts still demand respect for respiratory safety.
Bulk transport gets streamlined thanks to the solid, non-tacky nature of the compound. At lab scale, packing the material in amber glass jars keeps light exposure low, safeguarding stability over shelf life. On the rare moments when liquids or slurries are needed, labs measure by the milliliter, not the gram. Solid compaction effects require users to break up lumps before weighing, which I’ve found especially true after extended storage.
Those seeking tighter batch control focus on purity, moisture content, and trace contaminants such as palladium, iron, or residual solvent. NMR and mass spec readings help with batch authentication, not just for regulatory approval but also for reaction reproducibility. The HS Code most often assigned to this material falls in line with organo-iodine compounds, and import/export paperwork reflects these particulars for customs processing.
I’ve worked alongside procurement teams who require a certificate of analysis on every lot. These teams scrutinize the document for melting point checks, loss on drying figures, and IR spectra—details that prove batch-to-batch reliability for subsequent research or manufacturing.
Based on the structure and physical form, 4-(4-Iodo-1H-Pyrazol-1-Yl)Piperidine brings known hazards typical of organoiodo intermediates. Eye, skin, and inhalation exposure risks demand glove use, bench shielding, and fume hoods as standard tools. Chemical safety sheets detail the presence of potential thyroid-disrupting properties linked to the iodine atom, a concern echoed by toxicologists in the lab safety community. Waste disposal treats remnants as halogenated organics, routing liquids and solids through licensed handlers to avoid watercourse contamination.
I’ve seen careless storage cause bottle seals to loosen, releasing pungent odors and increasing the risk of iodine vapor exposure. Cabinets equipped with spill trays and ventilation keep these risks in check and protect the health of those working at scale, reducing the chance of harmful incidents.
This compound’s ability to participate in the formation of complex molecules in pharmaceutical and agrochemical industries stands out from firsthand experience at the bench. The sturdy reactivity profile supports C–N, C–C, and C–O bond formation, with minimal decomposition under reaction conditions. In the routes to next-generation drug candidates, its modular nature lets chemists build out new analogues without abandoning scalable routes.
Many modern labs benefit from these compounds in their hunt for better molecular probes or more effective active pharmaceutical ingredients. The raw material flexibility gained from the pyrazole-piperidine combination accelerates lead generation, while also introducing the need for precise safety controls at every stage—from storage to disposal.
