2-(Piperazin-1-Yl)Pyrimidine stands out in the chemical world for its unique blend of functional groups. Recognized by its formula C8H13N5, this compound brings together a six-membered pyrimidine ring and a piperazine unit. These two features open up a broad range of reactivity for raw material development in pharmaceutical synthesis and chemical manufacturing. The connection between two nitrogenous rings defines its structure, providing selectivity in chemical reactions not always possible with simpler amines or similar nitrogen heterocycles.
Looking at this compound on the lab bench, its most frequent form is as an off-white solid, sometimes turning up as free-flowing powder, crystalline flakes, or even pearls depending on synthesis and purification. Industrial specification lists its purity above 98%, critical for maintaining batch quality in higher-end applications. The substance shows a melting range, often clustered between 115°C and 122°C under standard conditions. Its density hovers around 1.3 grams per cubic centimeter, a detail that matters for measuring, transporting, and dissolving. Good solubility in polar solvents makes it amenable for formulation into various solutions, whether for research or for direct use as an intermediate.
C8H13N5 describes more than just atoms. This molecule pairs the electron-rich pyrimidine ring with the flexibility and basicity of piperazine, producing a backbone used again and again in organic synthesis. Molecular weight clocks in at about 179.23 g/mol. This makes molar calculations straightforward for chemists measuring out stoichiometric amounts. Its precise configuration—a 1-piperazinyl group at the 2-position on the pyrimidine—ensures it locks in well during substitution or condensation reactions, giving reliable yield, especially when used as a building block for pharmaceuticals.
Producers and end-users trust only batches that meet standard specifications. Packaged material must come with supporting certificates listing melting point, loss on drying, assay by HPLC, and impurity profiling. The HS Code, commonly listed as 2933599090, specifies import and export classification globally for customs and regulatory tracking. Material safety data identifies it under certain classifications—not flammable at room temperature, stable under standard storage, but known to be irritating to eyes and mucous membranes. Mitigating inhalation or prolonged skin exposure via gloves, eye protection, and proper ventilation is not a matter of red tape—it’s about real-world safety in everyday lab practice.
Daily material handling distinguishes between powder, flakes, crystal, and pearls for practical reasons. Powder disperses swiftly but is prone to airborne loss, so facilities must use dust control measures. Flake and pearl forms reduce that risk but may dissolve more slowly for users preparing solutions. Crystalline forms provide the most reliable melting and dissolution profiles, and bulk transport relies on accurate measurement of packed density. Shelf stability stretches for at least two years if kept dry, in airtight containers away from strong acids, oxidizers, or heat sources.
The inherent risks with 2-(Piperazin-1-Yl)Pyrimidine reflect standard practice for mid-level organic chemicals. No explosive risk under typical handling. Its biggest concern is irritation—eyes and respiratory tract respond negatively to airborne particulates or splashes. Training lab staff or chemical operators to use goggles, gloves, and fume hoods makes direct exposure unlikely. If the raw material gets on skin, washing with soap and water is usually sufficient. Material safety sheets recommend emergency eyewash stations and exhaust ventilation for any facility processing kilogram-scale lots. Its low volatility means accidental inhalation is rare, but chronic long-term exposure, as with many organonitrogens, should be controlled through tight procedural discipline.
Demand for 2-(Piperazin-1-Yl)Pyrimidine has grown because it sits at a crossroads between chemical reactivity and product safety. Medicinal chemists reach for it because the piperazine core and pyrimidine moiety together can spawn a surprising range of pharmaceuticals—antipsychotics, antiviral agents, kinase inhibitors, and more. Diagnostic reagent companies value it for its coupling efficiency, saving days in process time and reducing the need for complex purification. Robust supply chains depend on a predictable, high-quality raw material, which lets end users avoid batch failures and product recalls. Its reproducible melting, density, and purity grease the gears of chemical production lines, reaffirming why precise specifications and handling guidelines matter every time a new lot arrives at the loading dock.
Responsible sourcing and proper handling stand out as the best ways to avoid the handful of risks this compound presents. Facility audits, supplier reviews, and third-party lab confirmation go far in catching impurities or mislabeled lots before they reach the production floor. Investing in airtight, chemically resistant containers helps with long-term storage and prevents cross-contamination, especially during humid weather or temperature swings. Companies that educate workers, maintain clear labeling, and strictly follow the outlined HS Code build resilience into every step, reducing health risks while holding product quality to the highest standard.
Any lab or factory handling this substance must focus on accurate measurement, airtight containment, and regular staff training. Sharp adherence to specifications, along with real attention to safe use, not only supports compliance but also reflects an organization’s long-term commitment to scientific progress and staff well-being. Recognizing these essentials delivers the best results whether scaling up a synthesis, packing shipments, or developing new pharmaceuticals.
