2-Amino-3,5-Dibromopyrazine stands out in the chemical world as a raw material found across both research and production laboratories. As the name says, it is a dibromo-substituted pyrazine carrying an amino group, and anyone who has handled pyrazines knows the unique, earthy scent some of these compounds have. Its molecular formula is C4H3Br2N3, giving it a solid, reliable backbone for synthesis. Over the years, this compound has gained importance for its role in pharmaceutical intermediates and in agrochemical research, becoming a critical building block for those tweaking molecular structures to discover new traits.
The skeletal structure shows a six-membered aromatic ring with two nitrogens at positions 1 and 4, amino group at position 2, and bromine atoms at positions 3 and 5. This symmetric substitution can have an impact on electron distribution, which in turn affects reactivity. Chemical formula: C4H3Br2N3, molecular weight: 267.90 g/mol. The pyrazine ring system often increases the stability of the molecules built from this base, which appeals to researchers wanting predictable reactivity. Those working with heterocycles like this often appreciate the benefits of distinct and well-understood scaffolds.
You can spot 2-Amino-3,5-Dibromopyrazine by its solid, crystalline form under typical storage conditions. Sometimes, it shows up as off-white to light yellow flakes or powder, reflecting natural variation between batches or manufacturers. It rarely appears as large crystals, so most users encounter it as a fine particulate or flat flakes. This solid state lets chemists weigh and handle it without fuss. The density averages at 2.373 g/cm3, which is denser than many lighter organics, making it easy to separate from solvents during purification steps. It does not dissolve readily in water but interacts with organic solvents like DMSO or DMF, supporting its use in organic synthesis.
Nobody takes a bag of raw organic chemicals lightly. 2-Amino-3,5-Dibromopyrazine deserves respect both in the lab and during transport. It has not triggered any red flags as an acutely hazardous or highly toxic agent, but as with most brominated organics, gloves and goggles matter. Prolonged or repeated contact could cause irritation. Adequate ventilation or a well-tuned fume hood ensures volatile traces or dust do not build up. It is not outright flammable, but care with heating and open flames makes sense. Many suppliers note a storage recommendation at room temperature, away from moisture and sunlight, to avoid degradation. Shipped under the HS Code 2933999099, it fits in the larger family of heterocyclic compounds containing nitrogen atoms.
Organic chemists find 2-Amino-3,5-Dibromopyrazine a valuable intermediate, especially for making more complex scaffolds in the hunt for bioactive molecules. The dibromo groups attract attention for their potential in Suzuki and Buchwald-Hartwig cross-coupling reactions. With the amino group ready to act as a nucleophile, it opens up functionalization opportunities, letting researchers diversify chemical libraries with minimal fuss. In medicinal chemistry, few building blocks combine reactivity and ease of purification like this one, and you can see it referenced in synthetic routes for kinase inhibitors and other classes of advanced drugs. Agrochemical firms have also tested related structures for pest management research, using its core to build out new candidates. Its role as a raw material continues to expand as cross-coupling chemistry evolves.
Long-term stability presents few challenges—the molecule stays robust when kept dry, cool, and in sealed containers. Oxidizing conditions can break it down, especially if high temperatures are involved; moisture can also lead to slow decomposition over extended periods. I always keep organics like this in tightly capped glass bottles with silica gel where possible. After spills, sweep up with minimum dust, use gloves, and collect for safe disposal through authorized chemical waste channels. Disposing of excess or contaminated material through standard hazardous waste streams avoids accidental exposure and environmental harm, a practice anyone working in labs picks up quickly.
Anyone scaling reactions with 2-Amino-3,5-Dibromopyrazine faces a couple of hurdles. The main one comes from its limited solubility in some solvents, which means careful choice of reaction partners and conditions pays off. In my own work, dissolving a stubborn brominated compound often came down to patience, gentle heating, or choosing DMSO as a solvent—messy, but effective. Dust control has its moments, especially when prepping grams for pilot scales. The best answer stays consistent: closed containers, local ventilation, and a towel for wiping up the benchtop. Sourcing consistent material can matter for those ordering large batches, as purity differences affect yields down the line. Working with reliable suppliers, and using fresh material when possible, takes care of many headaches.
HS Code: 2933999099 matches it under heterocyclic compounds. Melting point sits between 185-190°C, a good indication of stability and a quick check for quality. It remains stable at ambient conditions, keeping long shelf life if moisture does not intrude. Appearance: solid, flaky to powdery. Formula: C4H3Br2N3. Density: about 2.373 g/cm3. Solubility: low in water, better in polar aprotic solvents. Safety: minor irritant, not highly hazardous. Uses: pharmaceutical intermediates, agrochemical research, chemical synthesis. Structure: six-membered pyrazine ring with two bromines, one amino group. Common packaging: sealed vials from a few grams to kilogram pails, always inside secondary containment for shipping. Handle with gloves, avoid inhaling powders, store in cool, dry place.
