2-Acetylthiophene shows up across the chemical market as a valuable raw material. This compound, defined by the molecular formula C6H6OS, comes from a class of heterocyclic organosulfur chemicals. Often called by its CAS number 88-15-3, it features a thiophene ring bonded with an acetyl group at the second carbon. These structural details shape how it behaves, how it interacts, and what roles it can play in different industries.
From personal experience in the lab and working with large-scale producers, the physical state of 2-Acetylthiophene matters a lot depending on what you are doing. It lands on the bench as a pale yellow or light brownish liquid, sometimes showing up as small crystals or flakes if subject to lower temperatures. I have handled bottles labeled "pearls," but it’s the liquid that usually gets poured out, especially when blending perfumes or prepping for syntheses. Although it stays as a liquid at room temperature, it may put out a noticeable odor with a hint of both sweetness and earthiness—often the first thing chemists mention when discussing its sensory impact.
On a molecular level, 2-Acetylthiophene stacks its chemical traits through the fusion of a five-membered sulfur-containing thiophene ring and a carbonyl group characteristic of an acetyl functional group. This construction means the electron cloud density around the sulfur is different compared with benzene-based molecules. Where synthesis or reactivity matter, chemists notice that the acetyl group at the alpha position (next to sulfur) opens new doors for further transformation, particularly for pharmaceutical intermediates. It weighs in at a molecular mass of about 126.18 g/mol, and its structure can make it soluble in organic solvents like ethanol, diethyl ether, and chloroform. Standard water solubility remains low, so separation processes factor that in if you’re running extractions or purifications.
For trade, handling, and regulatory purposes, 2-Acetylthiophene falls under the HS Code 2934.99.90.00—a part of chemical and allied industries listings. Delivery drums or sample bottles often list its purity, typically above 98%. In industrial applications, purity can impact downstream chemistry, so buyers closely examine certificates of analysis. Density hovers around 1.13-1.16 g/cm³ at 25°C, a reminder that it sinks below water in spills. Melting occurs near -1°C, and boiling arrives near 224°C. These numbers set its use in both cold storage and heated reaction environments.
Working with 2-Acetylthiophene, especially in poorly ventilated spaces, quickly highlights its harmful potential. Vapors irritate the eyes, skin, and respiratory tract. My first exposure—just from opening a bottle without gloves—led to redness and itching lasting several hours. Proper PPE means goggles, nitrile gloves, and lab coats. Inhalation brings headaches or drowsiness in heavy concentrations. The chemical sits in the flammable liquids category; its flash point ranks around 96°C, so open flames or heating mantles without temperature control can trigger a fire. Those working with it know to plan for spills using absorbent material, keep containers tightly sealed, and store in cool, dry places without sunlight.
2-Acetylthiophene acts as a linchpin in synthesizing flavors, fragrances, and pharmaceutical intermediates. In my role assisting with regulatory compliance, companies repeatedly looked toward this chemical for its cost-effectiveness in bulk production of heterocycle derivatives. Its scent—worn by synthetic musk and earthy flavorings—has helped perfumers stand out in a crowded market. Medicinal chemists lean on it to build more complex thiophene-based drugs, exploiting its reactive carbonyl and aromatic sulfur to couple with new groups. Beyond pharma and scents, it supports electronics, dye formulation, and agricultural chemistry, demonstrating surprising versatility. Technical teams prize its ready reactivity and moderate cost compared to other building blocks.
The supply chain for chemicals like 2-Acetylthiophene is tightly monitored. From personal discussions with plant managers and handlers, companies increasingly track both origin and transit conditions. Spills during transit bring not just hazards but compliance headaches. Responsible suppliers equip their packaging to prevent leaks and send detailed documentation as requested. Waste generated during synthesis requires incineration, as it leaves behind hazardous residues. Green chemistry advocates push for more recyclable alternatives and less toxic byproducts whenever 2-Acetylthiophene features in synthetic routes, but its particular ring structure gives little room for perfect substitutes.
Many labs have stepped up their game with improved ventilation systems, better spill kits, and more rigorous labeling. Responsible sourcing from manufacturers who outline impurity thresholds, batch traceability, and clear safety data sheets helps manage downstream risk. More facilities now run routine safety drills tied to chemicals with flash points below 100°C. Real progress comes from hands-on training—new technicians do well with guided practice sessions, learning both the risks and the practical ways to keep things under control. Digital tracking for batch origins and cradle-to-grave disposal logs meets growing regulatory expectations while improving overall safety culture.
Chemical supply chains lean on compounds like 2-Acetylthiophene for a reason: without it, a chunk of modern flavorings, specialty pharmaceuticals, and electronics would struggle to meet demand. From early days as a student—working late on synthesis runs—I remember calculating yield, checking purity, and reading labels where this thiophene appeared. It taught me the impact of elemental substitutions and reinforced the value of safe, transparent handling. As industries wrestle with balancing creativity, safety, and sustainability in chemical design, 2-Acetylthiophene provides a real example of both opportunity and challenge in today’s marketplace.
