2-(2,5-Difluorophenyl)pyrrolidine stands as a small organic molecule built from a pyrrolidine ring attached to a benzene ring with two fluorine atoms—one at the 2-position, another at the 5-position. The layout isn’t just for show. The pyrrolidine core offers structural flexibility, while those two strategically placed fluorines increase metabolic stability, making the material stand out as a smart building block in pharmaceutical chemistry. In labs, this compound often turns up as a raw material, or sometimes finds its way into larger molecules shaping modern therapies or crop protection agents.
Most samples of 2-(2,5-difluorophenyl)pyrrolidine arrive as a solid—either as crystalline flakes or fine powder. Depending on how it’s purified and handled, its look can shift: small crystalline pearls for higher grade batches, amorphous off-white powder for bulk industrial use. The scent tends to be mild, and you won’t find this compound in a liquid state at room temperature. Its melting point generally sits somewhere in the 80–100°C range, though fluctuations pop up with trace impurities. The density clocks in just above 1 gram per cubic centimeter. The compound dissolves in common organic solvents like chloroform or dichloromethane, enabling solution-phase syntheses when material gets scaled up beyond bench-top tasks.
The molecular formula reads C10H11F2N. Each part plays a role: the pyrrolidine ring brings nitrogen, the difluorophenyl portion slots in strength at specific sites for further reactions. Hydrogen count affects solubility and reactivity, fluorines guard sensitive positions from over-oxidation or unwanted metabolic attacks. Things like density and melting point stem from this core structure; ring tension, aromatic stacking, and hydrogen placement determine much of how the powder acts in the world, not just in theory.
Industrial specifications often call for a minimum purity upwards of 97% for specialized use cases in pharma or agrochemicals. Buyers look for tight control on residual solvents since trace leftovers can matter down the line in synthesis or material compatibility. For shipping and customs, the HS Code for similar organo-nitrogen compounds lands in the category of 2933.19. Under this code, authorities track and regulate bulk batches to limit illicit diversion or improper applications. Years spent working with customs paperwork teach that these codes can make or break timely delivery, and mistakes often only show up after materials hold up at port.
Handling this compound safely takes more than gloves and goggles. Direct contact with the eyes or skin can trigger irritation—nothing out of the ordinary for small fluorinated aromatics but still worth watching. Inhalation risks exist during weighing and blending powders for pilot plant runs. Chronic exposure isn’t well-mapped due to the material’s intermediate status, but similar compounds warn against repeated handling without proper ventilation. Once, after a few hours sorting vials in a cramped prep lab, I noticed a mild headache and took it as a reminder: always respect threshold limits. Material Safety Data Sheets highlight these risks and point toward chemical-resistant gloves and local exhaust systems, not open windows or half-measures.
Most direct harm comes from accidental exposure in confined spaces. Fortunately, the substance doesn’t volatilize easily—still, small particles can get airborne during milling or bottle transfers. Clean-up needs a cool head and the right absorbents. Fluorinated aromatics don’t break down quickly in the environment, lingering longer than many benzene relatives. The European Chemicals Agency lists waste codes to prevent careless dumping; responsible handlers aim for sealed disposal in incinerators rather than drainage or landfill. After seeing improperly disposed raw materials gumming up filtration plants, it’s clear why attention to discard protocols matters not just for workers but for ecosystems hanging in the balance.
In the world of synthesis, 2-(2,5-difluorophenyl)pyrrolidine doesn’t often end up as a finished product. Instead, its key role lies as a stepping stone. Medicinal chemists respect this compound for what it brings to the table: the ability to substitute the pyrrolidine ring into more complex frameworks, and the stabilizing effect fluorines have on drug metabolism. Bulk shipments head to contract manufacturers for integration into serval small molecule drug candidates or specialty agrochemical formulas. The material’s versatility also opens doors in polymer science, where its resistance to breakdown helps craft niche specialty plastics. Each use case reminds us that value in chemicals springs not just from what they are, but what they do for the next step.
Safer handling doesn't spring from a single checklist. In my experience, regular training proves more effective than thick written procedures. Refresher courses on glove integrity, scales, and local fume hoods beat rote memory. Replacing hand-poured transfers with semi-automated dispensers cuts down airborne dust, something I’ve seen make a quantifiable difference on personal air monitors in crowded pilot spaces. On the disposal side, batch labeling with barcoding links back to the originating work order, steering waste to the right incinerator and keeping surprises off city water reports. In the long run, real safety stems from small habits—ventilating storage areas, auditing chemical inventories, sharing near-miss stories in group meetings. These pieces go further than policy alone, shaping the culture around every raw material, not just those marked hazardous.
