1-Ethylpiperazine stands out as a versatile organic compound, recognized by its distinct molecular formula C6H14N2 and a molecular weight of 114.19 g/mol. This compound belongs to the family of piperazines, a group that shows up in everything from raw chemicals for manufacturing to pharmaceutical intermediates. Its systematic structure places a single ethyl group onto the nitrogen of a six-membered piperazine ring, conferring physical and chemical properties that turn up in practical, day-to-day chemical labs. Chemists, especially those familiar with heterocyclic amines, find the unique stability and basicity of 1-Ethylpiperazine useful, since its structure creates a mild base that doesn’t corrode surfaces or degrade storage materials.
The most notable thing about 1-Ethylpiperazine on the bench is its liquid consistency at room temperature, usually appearing as a clear or faintly yellowish liquid. In colder settings, it can sometimes manifest as a soft, crystalline mass or solidify, but as soon as the ambient temperature rises above its melting point, which is around -2°C, it moves straight back to liquid form. It holds a boiling point near 164–167°C, making it safer to handle compared to many lower molecular weight amines that evaporate quickly or cause inhalation hazards. Its density floats around 0.91 g/mL, light enough to allow easy pouring and mixing yet not so volatile that it evaporates off benchtops. Those who spend their days measuring chemicals can appreciate the lack of annoying flakes, powders, or pearls to chase around—liquids just work for batching and blending.
This compound usually ships under Hazardous Materials regulations, not because it’s explosively dangerous, but because chemical transport always takes caution. Under international trade, 1-Ethylpiperazine is designated with HS Code 2934.99, which covers heterocyclic compounds with nitrogen heteroatom(s) only. Laboratories and production teams dealing with customs documentation have probably memorized this detail, since having the right Harmonized System Code speeds up import and export processes and keeps compliance officers happy.
Where practical chemistry happens, the details matter. 1-Ethylpiperazine behaves as a relatively weak base, which is useful—in many pharmaceutical and specialty chemical syntheses, overly aggressive bases introduce byproducts or unnecessary risks. Its water solubility makes for straightforward cleanup, and people handling small volumes appreciate that it doesn’t form hazardous precipitates or foamy layers. Still, one shouldn’t let its mild nature fool them. It gives off a fishy, amine-like odor that lingers, so fume hoods or proper ventilation always deserve respect. As with many low-molecular-weight organic amines, it can irritate the skin and mucous membranes, causing redness or discomfort on direct contact. Personal experience with a minor spill shows that gloves, goggles, and lab coats aren’t only for show—they’re essential.
Safety data for 1-Ethylpiperazine draws from standard chemical practices and regulatory findings. This compound is classified as harmful if swallowed, inhaled, or comes into contact with skin. The irritation it causes generally doesn’t escalate into serious injuries unless a large quantity is mishandled or someone develops an allergy after repeated exposure. Still, ignoring ventilation or skipping gloves leaves even the most careful workers vulnerable to headaches, nausea, and rashes—reminders that basic precautions matter. In contrast to strong acids or corrosive agents, 1-Ethylpiperazine doesn’t blister surfaces instantly, but prolonged contact with rubber or some plastics can cause slow degradation. This chemical’s vapor pressure remains moderate, which reduces but doesn’t eliminate risks from inhalation. Guidance from chemical safety authorities, including Safety Data Sheets, always comes down to solid common sense: store it tightly sealed, away from heat sources, oxidizing agents, and food preparation zones.
Manufacturers and research chemists often turn to 1-Ethylpiperazine as a valuable raw material in creating pharmaceuticals, agricultural chemicals, and specialty polymers. The piperazine backbone acts as a scaffold for drug designs, while the ethyl group modulates absorption or reactivity. Combining 1-Ethylpiperazine with activated carbonyls, alkyl halides, or acylating agents opens paths to new molecules, many of which have direct activity in antiviral, antihistamine, and antifungal applications. Some chemical engineers use it to tweak properties in polymer synthesis, lending flexibility without sacrificing chemical resistance. In every use case, purity determines results. Only high-purity 1-Ethylpiperazine gives consistent, reliable results in downstream reactions, while lower-quality batches introduce impurities that can break processes or create hazardous byproducts downstream.
Disposal of any organic amine, even those that seem straightforward like 1-Ethylpiperazine, deserves respect. It should never go straight down the drain, since its nitrogen-rich structure can feed bacteria or complicate wastewater treatment. Disposal in line with local hazardous waste protocols, using containers marked for organics, shields both people and the wider ecosystem from accidental contamination. Experienced lab managers set up collection for waste amines and ensure everything that leaves the building is neutralized or treated. In the bigger picture, minimizing disposal starts with smarter use—careful measuring, using only the required amount, and reusing what’s safe and feasible cuts waste at the source. Awareness about environmental load leads workers to advocate for green chemistry alternatives, though not all reactions have substituted raw materials yet.
1-Ethylpiperazine has a chemical formula of C6H14N2, molar mass of 114.19 g/mol, and a boiling point near 164–167°C. Its density stands at around 0.91 g/mL at 20°C, and it usually appears as a clear colorless to light yellow liquid. Those sourcing it for production or trade purposes typically list the HS code as 2934.99. Even though it has no overwhelming hazards compared to more aggressive amines, its handling calls for basic PPE, smart storage, and tough attention to safety details so that minor spills don’t escalate into bigger concerns.
