1-Cyclohexyl-1H-Pyrrole-2,5-dione stands out as a solid chemical raw material used in a variety of specialty and industrial applications. This compound falls under the pyrroledione class, blending the cyclohexyl ring structure with a pyrrole dione framework. Across chemical manufacturing, polymers, pharmaceuticals, and research, this molecule has made its way as both an intermediate and a core raw material. Demands for specialty purity, consistency in structure, and clear understanding of its characteristics set the tone for its use in controlled settings.
Digging into its molecular structure, it presents a unique combination: the cyclohexyl group adds non-aromatic flexibility, while the pyrrole-2,5-dione ring solidifies its reactivity. With a molecular formula C10H13NO2 and a molar mass near 179.22 g/mol, each atom’s placement impacts the compound’s interaction with solvents, catalysts, and reagents. Chemical drawings show a five-membered ring fused to a six-membered saturated ring, creating both steric hindrance and stability unseen in simpler pyrrolidines.
Based on direct handling and standard documentation, 1-Cyclohexyl-1H-Pyrrole-2,5-dione usually comes in the form of off-white to pale yellow flakes, crystalline powder, or granulated pearls. Its appearance depends on the production route and processing methods. At room temperature, this compound maintains a solid state, resisting liquefaction unless subjected to elevated heat or solvent dissolution. The density hovers between 1.10 and 1.20 g/cm³, making it neither the densest nor the lightest material for lab work—just right for steady, reliable weighing and mixing. Unlike volatile liquids, it does not easily evaporate, limiting the risks of inhalation exposure.
In controlled storage, 1-Cyclohexyl-1H-Pyrrole-2,5-dione offers robust shelf stability as long as containers remain dry, sealed, and protected from direct sunlight. Moisture absorption may alter physical form—turning flakes into slightly sticky solids—though this rarely leads to chemical breakdown. Solubility remains modest in water, but increases significantly in organic solvents like acetone, ethanol, and DMSO. Preparation of working solutions often calls for careful weighing and gradual mixing to avoid formation of lumps. In powder form, static can become an issue during weighing, so grounding equipment helps maintain safe, accurate measurements.
Regular work with 1-Cyclohexyl-1H-Pyrrole-2,5-dione means understanding its hazardous profile. According to GHS classification, ingestion, inhalation of dust, or contact with skin and eyes may cause mild to moderate irritation. No acute toxicity profile reaching high danger has emerged, but like any organic chemical, gloves, goggles, and proper local exhaust ensure a safe workspace. Dust can trigger respiratory irritation for sensitive users, so good ventilation and particle masks keep risk under control. The compound lacks strong odor and isn’t prone to violent reactions in ambient lab conditions, making accidental spills and contact much less hazardous compared to caustic acids or bases. Standard protocols include sealing containers after use, keeping working surfaces clean, and documenting every amount transferred to protect end users and prevent cross-contamination.
For customs and international trade, 1-Cyclohexyl-1H-Pyrrole-2,5-dione typically carries the HS Code 2933.39.00, which covers heterocyclic compounds containing an unfused pyrrole ring. As supply chains and logistics enforce stricter traceability, shipments require correct declaration under this category to comply with import-export laws. No global restrictions block its sale or use for most industrial and academic activities, though users in the pharmaceutical sector need to cross-check for compliance with local substance lists and precursor controls. Handling declarations and material safety data sheets (MSDS) builds transparency and supports end-user confidence.
My own experience with similar pyrrole derivatives comes through work in pigment and intermediate synthesis. 1-Cyclohexyl-1H-Pyrrole-2,5-dione functions as a versatile building block, especially where manufacturers need the cyclohexyl group to boost solubility in nonpolar systems or enhance stability of final products. In polymer chemistry, this compound participates in step-growth reactions, serving as a monomer or a functionalized additive, which manipulates material properties like tensile strength or elasticity. Pharmaceutical developers use it as a masked amine source, finding ways to attach or modify bioactive groups for targeted drug design. Academic labs look at its structure-activity relationships for potential cancer therapeutics or enzyme inhibitors.
As chemical regulations and sustainability draw more focus, responsible use of 1-Cyclohexyl-1H-Pyrrole-2,5-dione starts at the raw material source. Supporting responsible sourcing, I check supplier records and ask for detailed certificates of analysis to avoid hidden contaminants that might disrupt downstream work. Waste management plays a big role: solvents from recrystallization or washing must pass through approved disposal channels, keeping labs free from environmental violations. Since health questions always crop up with organic intermediates, I’ve advocated for routine safety reviews, tweaking handling guides so even new technicians avoid accidental inhalation or contact. Updating safety data sheets based on latest research helps keep both new and experienced staff aware of evolving risks.
Suppliers should provide specifications outlining minimum purity (usually above 98%), melting range, water content, and clear description of the physical form—be it flakes, powders, pearls, or solid crystalline mass. These markers make batch selection easier for technical buyers who need reproducible results. In material properties, I look beyond headline figures: it’s about checking flowability (especially for powder forms), hygroscopicity, and compatibility with working solvents and reagents. Reliable packing (double-sealed polyethylene bags or drums) allows safe shipment over long distances, and anti-static barriers lower risk of accidental discharge during handling. Simple QA checks with IR, NMR, and mass spectrometry reinforce that what’s ordered matches project needs.
