1-Bis(4-Fluorophenyl)Methylpiperazine belongs to a chemical class that brings together piperazine with two 4-fluorophenyl groups attached to a central carbon. It shows up in research and industrial settings, especially where the manipulation or study of fluorinated aromatic rings is necessary. Chemists and researchers lean on this sort of compound for structure-activity relationship studies or as part of molecular scaffolds for more advanced synthesis. For anyone handling raw materials in specialty labs or synthesis facilities, this is one of those compounds that demands attention due to both utility and handling risks.
This material appears as a solid in most cases, usually as white to off-white flakes, crystalline powder, or small pearls. Sometimes, you’ll find it pressed into pellets for storage or shipping, depending on the batch and supplier. The molecular formula stands at C17H18F2N2, showing a compact ring shaped by two fluorinated aromatic rings linked into a single piperazine backbone. Its molecular weight hovers around 288.34 g/mol, important for anyone concerned with precise batch calculations or purity checks. Most stocks get listed under the HS Code 2934999099, which covers a broad family of organic chemicals. Scientists and warehouse managers who deal with bulk orders will notice this code on bills of lading, customs forms, and inventory sheets, smoothing out the process of moving specialized materials across borders.
The physical state often sticks to solid at room temperature, melting roughly between 102 and 107°C, a range noticed in several test batches. This temperature range matters when planning synthesis or storage in climates that swing between extremes. In the hand, you’ll feel it as a dry, light solid, breaking into powder or small chunky pieces if put under pressure. It dissolves with ease in common organic solvents like dichloromethane or ethanol, but water resistance is high. Specific gravity, according to in-house measurements and supplier data sheets, lands near 1.12 g/cm³, a touch heavier than some related piperazine derivatives due to fluorine substitution. That weight, matched to moderate bulk density when loosely packed, can quietly complicate storage where shelf constraints run tight. For folks working in formulation, knowing whether you’re dealing with flakes, powder, or a crystalline mass can make glassware choice and mixing protocols much easier. The color rarely deviates far from white, with little to no scent in a well-sealed flask or jar. On rare occasions, off-white or cream hints indicate trace impurities, bringing up obvious quality control questions when end-use purity needs to hit over 99%.
This is a raw chemical, not intended for consumers or casual workbenches. Inhalation, skin, or eye contact should be avoided. The primary risks sit with allergic or irritant responses—working with gloves, goggles, and a fume hood remains the norm. Fine powder can become airborne when pouring or weighing, so working at reduced airflow or using a mask becomes worthwhile. Based on hazard data, the compound does not ignite easily, but storing away from strong oxidizers or acids is a must to dodge runaway reactions. Containers should stay tightly closed, in a dry, well-ventilated, and cool environment. Disposal requires careful planning since effluent containing traces might head to hazardous waste facilities, not standard drains or landfill, to avoid long-term environmental spread. Even warehouse labels stress on “Harmful” and “Irritant” icons, reminding staff of real risks. Chemical suppliers flag its use for research and development only—no intention for food, drug, or cosmetic work.
For organic synthesis, this compound often steps in as an intermediate. It offers a sturdy backbone for further modification, especially fluorination, which sits in high demand in medicinal chemistry for tweaking metabolic and receptor properties. Development chemists see this as a base point for building complex structures or as a template to study electron-withdrawing effects from fluorine on rings. Those same structures appeal to agrochemical research, where active ingredients often crave tight structural control and predictable degradation. In more advanced materials science labs, it serves as a jumping-off point for polymers or coatings where both durability and resistance to breakdown matter.
The presence of fluorine adds weight to regulatory scrutiny—per-fluorinated compounds in particular worry policymakers for persistence in environments and possible toxicity. Even if this piperazine derivative does not share the long-chained nature of environmental contaminants like PFOS or PFOA, supply chain actors need to document every step, ensuring compliance with REACH, TSCA, or local equivalents. Materials handlers take these requirements seriously, locking down receipts, annual inventories, and documentation for inspection. Disposal, reporting of waste, and exposure limits get wrapped up in a tighter regulatory net year after year. Global trade relies on clear harmonized codes and precise chemical data to avoid customs seizures or regulatory fines that impact the research timeline of downstream users.
Moving forward, material safety can jump by training staff on spill protocols, reviewing updated safety data sheets, and automating inventory so nothing slips past expiration dates. Adopting closed systems for mixing and weighing cuts exposure risks, while improved exhaust filtration handles the dust if spills do occur. Research labs benefit from digitized logs that track lot numbers, expiry, and storage location, letting anyone spot mistakes before they build. When working at scale, co-developing waste management plans with certified hazardous waste handlers protects both worker health and the future of surrounding communities. Sharing physical property data and empirical results on storage, purity, and solubility gives fellow researchers a shortcut to getting their projects right—something the chemical field thrives on.
