1-Acetyl-4-(4-Hydroxyphenyl)Piperazine pops up in many chemical supply lists. This compound steps out as a solid, often found as off-white to pale yellow flakes or crystalline powder, with a certain density hugging the 1.2 g/cm³ range. Folks who’ve spent time in the lab know it's not just the look that matters. The way it handles heat and moisture makes all the difference during storage and transport. Some batches can clump if not kept in sealed, dry containers. Scoop it out, and you’ll notice it's got a slight characteristic odor. Its molecular formula is C12H16N2O2, which speaks to a fairly sturdy backbone, not especially prone to spontaneous breakdown outside of strong acids or bases.
Manufacturers commonly call on this chemical for use as an intermediate, especially in the making of pharmaceuticals. The material checks typical purity specs by HPLC, usually landing around 98% or better in top-tier product. In industry, purity matters, since trace contaminants can throw off downstream reactions or ruin a sensitive final product. Specifications often list a melting point between 140°C and 144°C. Solubility skews towards good dissolution in methanol, ethanol, and in DMSO. Try water or simple hydrocarbon solvents, and you’ll run into cloudy solutions—so techs usually stick to what works. It's a non-volatile, solid-state compound, easy to weigh and portion. Granules, powder, and sometimes tiny crystalline pearls all flow through the supply chain, each form picked to match the buyer’s setup. Packing always prioritizes moisture barriers, since this molecule soaks up atmospheric water and can degrade if mishandled.
The chemical structure tees up a piperazine ring with one nitrogen wearing an acetyl cap, and another position sprouting a 4-hydroxyphenyl group. This setup draws out some unique properties. That hydroxy group likes to form hydrogen bonds. In practice, that means better interaction with polar solvents and a nudge in reactivity that’s valuable for further syntheses. Density and melting data come straight from hands-on measurements, not theory, so anyone in process development needs to double-check batch data against the lot being used. Visual breakdown: a central six-membered ring, with the acetyl group hanging off one nitrogen, and the aromatic ring, adorned with a hydroxy group, trailing from the other. Chemists eyeball this skeleton and see a typical drug precursor, compatible with standard organic transformations, including nucleophilic substitutions and acylations.
Shippers assign HS Code 293349 for this type of heterocyclic compound, so crossing customs lines rarely causes confusion. Safety data demands respect: though not classified as highly toxic, dust exposure can irritate the airways and skin. Gloves and goggles keep lab workers out of trouble. As a raw material, it raises some environmental flags—waste solutions require proper organic solvent handling, and folks avoid dumping residues down the drain. Local regulations often force users to collect and incinerate or treat waste, especially in large-scale industrial settings. Strong chemical odors sometimes bother sensitive noses, pointing to the need for proper fume hoods. In storage, it prefers dark, dry rooms, kept between 2°C and 8°C, and always away from oxidizers or strong acids.
The feel and flow of 1-Acetyl-4-(4-Hydroxyphenyl)Piperazine depend on form—flakes can clump but allow for easier weighing; crystalline powder handles with precision; pearls make for low-dust dosing in automated setups. Each form carries a dry, compact bulk density, with the powder sometimes prone to static. Regular handling routines matter: those exposed to lots of powders know how fine dusts can fly, so weighing stations get fitted with localized exhaust. Disposal tacks to chemical waste rules: segregated by-container, labeled by date and lot, and locked before transit. In my time as a chemistry student, careless disposal of related compounds resulted in headaches for the department’s safety officer, emphasizing the benefit of well-documented protocols. This chemical, like many organic intermediates, falls under “handle with care, treat with respect.”
Anyone ordering 1-Acetyl-4-(4-Hydroxyphenyl)Piperazine, whether for research or production, runs through a mental checklist: Fresh certificate of analysis? Container integrity? Batch number traceability? The industry sets a high bar to keep accidents rare. For product developers, I’ve seen that rushing to use a new lot without confirming solubility and purity leads to batch failures—a quick quality control step usually avoids expensive mistakes. Researchers branching into new pharma intermediates will appreciate its stability in storage and safe handling profile, provided all standard chemical hygiene measures remain in place. On the supply side, chemical wholesalers track every outgoing shipment, document by HS code, and update clients with revised safety data sheets as laws shift. It’s a hands-on, eyes-open approach, shaped by a long list of lessons learned from near misses and regulatory audits.
