1-(3-Methoxypropyl)-4-Piperidinamine falls under the umbrella of specialty chemicals favored across research, pharmaceutical, and industrial processing spaces. You find this compound classified by the HS Code 29333999, reflecting its category as an organic heterocyclic base. It comes from a family of piperidinamines often used by chemists looking to introduce nitrogen heterocycles into reaction pathways. Its chemical structure makes it appealing for applications where molecular modification or intermediate synthesis holds value.
With a molecular formula of C9H20N2O and a molecular weight of 172.27 g/mol, the compound shows a solid backbone for constructing more complex molecules. Chemists often see it as a crystalline solid at room temperature, though some describe it turning into fine flakes or a granular powder depending on its purity and how it’s stored. Usually white or off-white in appearance, it mixes readily with polar solvents, so it works well in solution-phase chemistry. Its density hovers around 1.0 g/cm³, bringing handling benefits—measuring by volume or weight becomes straightforward, a small but noticeable relief for those working in busy labs.
The molecular structure stays simple yet functional: one piperidine ring substituted at the nitrogen with a three-carbon chain capped by a methoxy group, and a primary amine sitting on the ring. The specific configuration, with the flexible alkoxypropyl side chain, gives the molecule unique reactivity not found in standard amine products. Raw material inputs include 4-aminopiperidine and 3-methoxypropyl bromide. Skilled staff handle these chemicals with full ventilation and skin protection due to their potential reactivity. The production process involves alkylation, carried out in controlled conditions to limit the formation of side products, which can complicate downstream use.
Like many amines, this substance emits a faint ammonia-like odor. Anyone with experience knows to keep it tightly sealed and away from moisture to maintain sample integrity. It carries hazard statements typical for primary amines—skin and eye irritation, risk if inhaled or swallowed, and potential for sensitization in some workers. On my bench, I never skip gloves and goggles handling it, no matter how routine the task. The compound doesn’t count among the most hazardous, but a careless approach—leaving open containers or skipping the fume hood—can lead to exposure and cleanup headaches. Fire risk remains low, but strong oxidizers nearby change the story, so segregation in chemical storage matters.
Depending on manufacturing and handling, it ends up as a crystalline solid, sometimes delivered as compact flakes, fine powder, or even small lumps. The shape comes from the crystallization and milling process rather than inherent properties, so seasoned chemists look at sample texture to judge purity and handling. Dryness is always key—moisture clumping leads to uneven flow and measure loss, especially problematic when weighing small quantities for synthesis runs. I always check by gently tapping the sample vial: free-flowing powder signals proper storage, sticky clumps point to water ingress, forcing another round of drying under vacuum.
Crystallographers study its solid-phase structure, often reporting monoclinic or orthorhombic geometry depending on preparation. Most researchers rely on its good solubility in water, methanol, and ethanol, opening up a range of reaction settings. In my experience, preparing standard solutions for analysis or reaction setup poses no challenge—as long as the solute stays dry until use, dissolution happens quickly. The high purity achievable means side reactions from trace byproducts rarely trouble routine synthesis tasks.
Beyond its primary use in R&D, the piperidinamine group offers a central site for derivatization, making it a nifty intermediate for API production or agrochemical work. Its reactivity reflects the amine’s nucleophilicity and the ether’s stability, bridging the gap between flexible organic modifications and stable, shelf-ready stocks. Manufacturers see value in its ability to survive storage yet jump into reactions as soon as it hits the flask. I’ve used it in reductive aminations—clean reactions and decent yields, assuming control over base strength and temperature. That flexibility saves time, especially when screening multiple routes for new compound libraries.
Suppliers provide a purity assay (typically >98%), specific melting point (in the range of 34–36°C), and density information, giving labs the numbers they need for batch calculations. Water content, as determined by Karl Fischer titration, stays below 0.5%, unless improperly handled. Well-run sourcing practices matter here; I always push for current certificates of analysis before accepting shipments—bad batches can throw off the entire week’s workflow. Packaging in sealed, light-blocking containers ensures shelf life, as UV exposure can degrade sensitive amine groups over long periods.
Day-to-day operations demand careful attention. Technicians keep sorbent mats and waste containers nearby, because safe practice comes down to the small habits: quick wipe-downs, secure bottle closures, and labeling every aliquot. Disposal meets local hazardous chemical guidelines, with clear records—no one wants a regulatory audit exposing poor habits. Safety data sheets back up these routines, spelling out what to do in case of spills or exposure, but real safety grows from experience and respect for what these molecules can do if mishandled.
Regulations reflect rising concern about both worker and environmental health. European REACH and US OSHA guidance require up-to-date documentation and safe exposure limits. Waste streams containing amine residues get treated before discharge, keeping chemical flows out of municipal systems. Teams involved in environmental, health, and safety review all bulk deliveries—routine, yes, but I’ve seen entire shipments held up until compliance reports pass muster.
1-(3-Methoxypropyl)-4-Piperidinamine shows its worth by offering a reliable structure for organic synthesis, manageable handling for trained staff, and proven utility in pharmaceutical and agrochemical pipelines. The key comes down to respect—respect for its hazards, its chemical potential, and the people who make use of it each day. Reliable supply, clarity in documentation, and vigilance in handling stand as essentials. Solutions arise from experience, training, and attention to detail—roots that keep both innovative chemistry and workplace safety thriving together.
