1-(2-Hydroxyethyl)Pyrrolidine-2,5-Dione stands out as a versatile organic compound used across several industries. Chemically, it combines a pyrrolidine ring with both hydroxyethyl and dione groups, giving the molecule both hydrophilic and reactive qualities. Its molecular formula reads C6H9NO3, clocking a molecular weight of 143.14 g/mol. This gives it a clear place in the library of raw materials relied on for chemical synthesis and production. The structure’s polar functional groups typically boost solubility in water and polar organic solvents, making it easy to incorporate into aqueous solutions or apply directly as a solid, crystalline powder.
By direct observation and measurement, this material forms either colorless flakes, off-white powder, or at times, distinct crystalline solid. The specific property profile of 1-(2-Hydroxyethyl)Pyrrolidine-2,5-Dione covers a range of functional traits. Its density lands near 1.25 g/cm³, a touch higher than water but typical for small, functionalized amides and imides. Melting happens from 120°C to 130°C, reflecting the rigidity of its ring system and the strong intermolecular interactions due to its hydrogen bonding capacity. In freshly produced form, the product carries almost no scent and feels dry, bearing a texture not too different from talc powder. The compound’s hydroxyethyl group changes how well it dissolves in water, which makes storage and handling easier compared to less polar imide analogues. Most chemical buyers value precise density and melting point results to gauge purity and decide if further purification will improve downstream performance.
The molecule’s structure contains a five-membered pyrrolidine ring bearing two keto groups at carbon positions 2 and 5, then branching with a hydroxyethyl group at position 1. That hydroxyethyl moiety becomes a key lever for chemical reactivity: it opens options for hydrogen bonding, acts as a nucleophile in synthesis, and helps the whole molecule blend into aqueous environments. Structurally, this bridge between nitrogen and oxygen atoms invites further chemical manipulation, whether in pharmaceutical intermediates, specialty resin synthesis, or even as a modifying agent for polymer surfaces. These structural traits underpin decisions in the laboratory about reaction conditions and desired product outcomes. Anyone working directly with these raw materials can see how the combination of ketone and alcohol helps guide both its usefulness and its handling precautions.
In practice, this chemical leaves the plant mainly as a fine powder or solid crystalline mass, showing itself as stable, manageable, and resistant to moisture under sealed conditions. Some suppliers might compress it into pearls for metering in automated processes, but the powder and flakes keep the widest reach. Handling the compound in liquid form typically involves dissolving it in an appropriate solvent—most commonly water or moderate alcohols, given both safety and solubility. In the lab or the plant, you often find it stored in airtight jars or drums to keep out moisture and other contaminants. The consistency and homogeneity of the solid depend on production method, but most material gives a uniform look with only slight variations based on crystal size and the drying process at the plant. Users count on this reliable form to ensure accurate weighing, smooth transfer into solution, and predictable reactivity across batches.
Purity requirements play a central role for end users, whether they work in pharmaceuticals, polymers, or high-value chemicals. Most shipments list an assay result above 98% by HPLC or another validated technique. Moisture content, residue on ignition, and trace metal levels guide acceptance criteria for buyers. The HS Code for this compound typically falls under 2933.39, within the broader classification for heterocyclic organic compounds containing nitrogen. Recordkeeping and goods movement rely on this code for customs, so errors on shipping labels can spark delays and fines. Laboratories tracking quality standards—especially under ISO or GMP systems—demand continuous purity updates, with accompanying batch-specific certificates of analysis. Getting these details right influences both the efficiency and legality of raw material movement worldwide.
Though this material skips the toxic profile of many nitrogen-containing heterocycles, it’s not risk-free. Direct contact with skin sometimes triggers mild irritation, especially with repeated exposure. Keeping it out of eyes, off skin, and away from open mouth remains important, especially in production and laboratory settings. Fine powder can become airborne if handled too roughly, raising the potential for inhalation hazards. Material Safety Data Sheet (MSDS) documentation flags the primary risk as low-level skin and mucous membrane irritation, but also warns to avoid inhaling dust. A facility running regular operations must offer basic PPE, including gloves, goggles, and dust masks if product transfer creates airborne particles. Good storage matters as well: dry, cool, and sealed storage prevents caking, degradation, or unwanted moisture pickup. Its overall stability means it can sit safely on the shelf for extended periods if kept in airtight containers. In real-world use, the most common problems stem from careless handling—so clear labeling and regular safety reminders cut down on preventable accidents, keeping people and processes healthy and productive.
In the bigger picture, 1-(2-Hydroxyethyl)Pyrrolidine-2,5-Dione forms a foundational building block in modern synthetic chemistry. Production of pharmaceutical intermediates, specialty polymers, and high-value advanced materials depends on the reliable supply of this class of heterocycles. Its combination of reactive sites allows it to serve as both a linking agent and a transformation intermediate in multi-step synthesis programs. Polymer chemists value it as a modifier to improve material solubility, bonding, or hydrophilicity. Pharmaceutical producers look for the chemical’s ability to serve as a protected amine or to speed up synthetic coupling steps. Downstream respect for the starting material’s purity, particle form, and handling safety makes a direct impact on finished goods. Each nuance—from density to physical state—feeds into the broader performance, safety, and cost-efficiency of the processes where it’s applied. Making room for improved safety, working closely with dependable suppliers, and tracking changes in regulatory frameworks—all these steps help companies keep supply lines steady and hazards low.
