1-(2-Furoyl)Piperazine stands out in the chemical industry for its role as a significant intermediate and building block in pharmaceutical research and organic synthesis. Many see it as a cornerstone for creating compounds where both furan and piperazine functionalities add unique value, leading to the development of active ingredients and specialty chemicals. The combination of the furoyl moiety—derived from furan-2-carboxylic acid—and the piperazine ring brings together two robust motifs found in a variety of bioactive molecules. Its IUPAC name underlines this hybrid structure: 1-(furan-2-carbonyl)piperazine.
The molecule shows clear definition with its explicit structure linking the furan-2-carbonyl group to the nitrogen atom of the piperazine ring. Chemists often describe its molecular formula as C9H12N2O2, resulting in a molecular weight of 180.20 g/mol. The furan ring, fused to the aliphatic piperazine, introduces aromaticity and enhances electronic properties. Structural clarity helps during synthetic planning. This backbone supports a wide array of modifications, which researchers take advantage of in developing new materials and drug candidates.
1-(2-Furoyl)Piperazine usually appears as a crystalline solid, though its precise form can range—some batches exhibit a fine powder consistency, while others arrive as compact crystals, small flakes, or even small pearls. This flexibility in form relates to slight differences in processing and storage. High purity 1-(2-Furoyl)Piperazine remains nearly white or off-white, but minor impurities can lend a faint hue. Product supplied in solid form brings practicality, especially for accurate weighing and dissolution. In standard conditions, it shows good stability, avoiding significant degradation under routine handling. Its specific density lies between 1.15 and 1.25 g/cm³, putting it in line with other heterocycle-containing organics. Melting points cluster between 65°C and 80°C, allowing for efficient melting in synthesis setups without undue risk of decomposition.
This compound demonstrates moderate solubility in organic solvents like dichloromethane, methanol, and dimethyl sulfoxide. In water, solubility drops, and forming a concentrated aqueous solution proves less feasible. Chemists value its manageable reactivity—the ketone group on the furoyl permits further derivatization, while the piperazine opens sites for substitution or ring formation. Those handling 1-(2-Furoyl)Piperazine in the lab notice it holds up well during short-term storage, suggesting a shelf life that meets industry expectations if kept in airtight containers, shielded from direct sunlight and moisture.
Manufacturers routinely supply material at purities above 98%, using analytical techniques such as HPLC, NMR, or mass spectrometry to confirm identity and composition. Typical lot specifications include minimal water content (below 0.5%), low ash, and stringent limits on heavy metals. Bulk materials often ship in polyethylene-lined drums or sealed pouches, with specifications for crystal size and physical uniformity addressed as required by downstream users.
Buyers, importers, and compliance officers regularly reference 1-(2-Furoyl)Piperazine’s Harmonized System (HS) code under the class for organic chemicals, often reporting 293349 or a regionally specific designation. Accurate classification supports smooth customs clearance, helps in applying tariffs correctly, and ensures labs know regulatory responsibilities for safe storage and transport.
Chemists in the pharmaceutical sector turn to 1-(2-Furoyl)Piperazine as a raw material for various active pharmaceutical ingredient (API) syntheses, especially where introducing a furan or piperazine ring can drive new biological activity. Beyond drugs, innovators in agrochemicals and fine chemical research adopt this molecule for synthetic experiments that require robust heterocyclic frameworks. The powder dissolves efficiently into organic reaction mixtures, and those working with it note it acts as a reliable intermediate, showing few side reactions and delivering good product yields.
Producers supply 1-(2-Furoyl)Piperazine in tightly sealed containers sized from laboratory sample bottles to kilogram-scale drums. Maintaining material quality through the supply chain means keeping moisture and oxygen exposure minimal. Handling this chemical demands care; protective gloves, eyewear, and access to fume extraction provide the baseline for daily work, as the compound can cause irritation on skin contact or if inhaled. While it carries fewer acute hazards compared to strong acids or bases, SDS documentation still tags it as potentially harmful if misused or improperly stored.
Toxicological data remain limited, though available studies suggest it causes mild to moderate irritation with direct exposure. Workers should avoid breathing dust and wash well after handling. Long-term data on chronic exposure lack robustness, so professionals in labs and warehousing draw on sensible precautions for all new organic intermediates. Waste management requires attention—collect dust, broken crystals, and solution residues in designated inorganic solvent waste, adhering to all company and municipal guidelines.
Speaking from time in the synthesis lab, weighing out 1-(2-Furoyl)Piperazine usually means checking for lumps or moisture in the jar—telltale signs the desiccator needs servicing. Many chemists have a “memory” for how different batches flow: some pour cleanly as a dry powder, others need gentle coaxing with a spatula. The difference rarely impacts reaction performance, but clear labeling and thorough documentation always help avoid mix-ups, especially when moving quickly on late-stage intermediates. It’s a material that rewards keeping things tidy—using pre-weighed sample bottles or falcon tubes can shave minutes off multi-step sequences, help catch mistakes early, and reinforce good safety habits every day.
