Product Name: Trimorpholinophosphine Oxide
Chemical Formula: C12H27N3O2P
Synonyms: TMPO, Tris(morpholino)phosphine oxide
CAS Number: 54553-90-1
Recommended Use: Organic synthesis, intermediate, catalyst
Manufacturer Contact: Industrial chemical supplier, Emergency telephone: CHEMTREC, Information line: provided on purchase documentation
Address: Commercial manufacturing or distribution location
GHS Classification: Acute Toxicity Category 4 (oral), Serious Eye Damage/Irritation Category 2A, Skin Sensitization Category 1
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause allergic skin reaction
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust or vapors, wear eye protection and gloves, wash hands thoroughly after handling, do not eat, drink, or smoke when using this product
Chemical Name: Trimorpholinophosphine Oxide
Common Name: TMPO
CAS Number: 54553-90-1
Concentration: >97% by weight
Impurities: Residual morpholine, by-products from synthesis (each <1%)
Additives: None
Inhalation: Move individual to fresh air, assist with breathing if needed, consult a physician for symptoms such as coughing or respiratory distress
Skin Contact: Remove contaminated clothing, rinse area with soap and plenty of water for 15 minutes, seek medical attention if irritation persists
Eye Contact: Rinse eye(s) cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, obtain medical help immediately for discomfort or vision changes
Ingestion: Never give anything by mouth to an unconscious person, do not induce vomiting, rinse mouth with water, call poison control or a doctor
Acute Symptoms: Burning of eyes or skin, gastrointestinal upset, respiratory irritation
Notes to Physician: Symptomatic treatment recommended; no specific antidote known
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray for small fires
Hazardous Combustion Products: Oxides of phosphorus, nitrogen oxides, carbon monoxide, possibly other toxic gases
Fire Fighting Instructions: Firefighters should wear self-contained breathing apparatus and full protective gear, cool exposed containers with water spray
Unusual Fire and Explosion Hazards: Dust may form explosive mixtures in air under some circumstances, product itself is not highly flammable but decomposition gases are hazardous
Personal Precautions: Evacuate non-essential personnel, ventilate area, avoid breathing dust or vapors, wear protective clothing including gloves, goggles, and appropriate mask
Environmental Precautions: Prevent product from entering drains, water courses, or soil, contain spillage with sand or absorbent material
Methods for Cleanup: Sweep up or scoop spilled solid, place in a suitable labeled container for disposal, decontaminate spill area with soap and water, ventilate and clean contaminated surfaces
Precautions for Safe Handling: Handle in a chemical fume hood or well-ventilated space, avoid all personal contact with skin, eyes, and clothing, do not eat, drink, or smoke near product, wash hands thoroughly after use
Conditions for Safe Storage: Store in a tightly closed original container, in a cool, dry, well-ventilated area away from incompatible chemicals (strong acids, bases, oxidizers), protect from direct sunlight and moisture, segregate from food and feedstuffs
Storage Temperature: Ambient room temperature preferred
Occupational Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limit for this compound; minimize exposure using good industrial hygiene
Engineering Controls: Chemical fume hood preferred, ensure adequate general and local exhaust
Personal Protective Equipment: Chemical resistant gloves (nitrile, neoprene), tightly fitting safety goggles, lab coat, long sleeves, closed footwear
Respiratory Protection: Use a NIOSH-approved respirator if airborne exposure risk exists, especially for dust or vapors
Hygiene Measures: Wash thoroughly after handling, change contaminated clothing promptly
Appearance: White to off-white solid, crystalline powder
Odor: Faint amine-like
Melting Point: 110-115°C
Boiling Point: Decomposes before boiling under normal conditions
Solubility: Slightly soluble in water, soluble in organic solvents
Density: Approximately 1.19 g/cm³ at 20°C
Vapor Pressure: Not determined (low volatility)
pH: Not applicable (solid)
Flash Point: No data, expected to be above 150°C
Partition Coefficient (log Kow): Not available
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal use and storage
Conditions to Avoid: High heat, exposure to moisture or strong light, contact with incompatible substances
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Hazardous Decomposition Products: Phosphorus oxides, nitrogen compounds, carbon oxides on thermal decomposition or combustion
Possibility of Hazardous Reactions: No dangerous reactions expected in normal handling
Acute Toxicity: Oral rat LD50 estimated at 300-2000 mg/kg (harmful if swallowed), no comprehensive inhalation or dermal data
Skin Corrosion/Irritation: Moderately irritating
Serious Eye Damage/Irritation: Causes eye irritation, may cause serious or prolonged discomfort
Respiratory Sensitization: Not enough studies available, avoid inhalation
Skin Sensitization: May provoke allergic skin reactions in sensitized individuals
Chronic Toxicity: No known chronic effects, no evidence of carcinogenicity, mutagenicity, or reproductive toxicity in available studies
Potential Symptoms: Eye, skin, respiratory irritation, allergic dermatitis, digestive upset
Aquatic Toxicity: Not classified, but potential risk to aquatic organisms at high concentrations
Persistence and Degradability: Data limited, expected to have moderate persistence; breakdown products may be harmful
Bioaccumulation: Data not available, unlikely to bioaccumulate significantly
Mobility in Soil: Low predicted based on low water solubility
Other Adverse Effects: Avoid release into the environment; not expected to deplete ozone or contribute to greenhouse gases
Waste Treatment Methods: Dispose in accordance with local, regional, and national regulations through a licensed chemical waste contractor
Contaminated Packaging: Triple rinse containers before disposal, then puncture and render unusable, send to approved landfill or incineration facility
Precautions: Avoid direct disposal to sewers, surface water, or natural environment
UN Number: Not assigned
UN Proper Shipping Name: Not regulated as hazardous for transport under most international guidelines
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not classified as marine pollutant
Special Precautions for User: Ship in tightly closed original container, use suitable cushioning to prevent breakage or leakage
Transport in Bulk: Not applicable
TSCA Inventory Status: Listed or exempt
EINECS / ELINCS: Listed
REACH Status: Registration required for quantities above 1 ton/year, compliance with safety assessment protocols
US SARA Title III: Not listed as a reportable hazardous substance
California Proposition 65: Not known to be listed
Canada WHMIS Classification: Not classified as controlled product
Other Regulations: Subject to workplace chemical safety standards and Right-To-Know provisions as applicable per region
