Product Name: Trihexyphenidyl Hydrochloride
Chemical Name: 1-Cyclohexyl-1-phenyl-3-(1-piperidyl)-propan-1-ol hydrochloride
Chemical Formula: C20H31NO·HCl
CAS Number: 52-49-3
EC Number: 200-135-5
Synonyms: Benzhexol, Artane
Recommended Use: Antiparkinsonian drug, anticholinergic agent
Manufacturer / Supplier: Contact local distributor or manufacturer
Contact Information: Refer to safety officer or health authority in your facility
GHS Classification: Acute Toxicity (Oral): Category 3, Specific Target Organ Toxicity (Single Exposure): Category 3, Eye Irritation: Category 2A, Skin Sensitizer: Category 1
Signal Word: Danger
Hazard Statements: Toxic if swallowed; May cause damage to organs; Causes serious eye irritation; May cause an allergic skin reaction
Precautionary Statements: Do not eat, drink, or smoke during use; Avoid contact with eyes, skin, and clothing; Wear protective gloves, protective clothing, and eye protection
Health Effects: Headache, dizziness, confusion, blurred vision, dry mouth, urinary retention, tachycardia, allergic reactions
Environmental Hazards: May have adverse long-term effects on aquatic environments
Label Elements: Toxic (skull and crossbones symbol), exclamation mark for irritation and organ toxicity
Chemical: Trihexyphenidyl Hydrochloride
Concentration: ≥98% (pharmaceutical grade)
Other Ingredients: Not applicable for the pure substance
Impurities: Trace amounts of chloride ions or manufacturing residues possible
Mixture: Product consists of single active ingredient for raw or bulk pharmaceutical use
Inhalation: Move person to fresh air immediately. Maintain open airway. Seek prompt medical attention if symptoms develop.
Skin Contact: Take off contaminated clothing. Rinse skin with soap and water for at least 15 minutes.
Eye Contact: Flush eyes with copious amounts of water for at least 15 minutes. Lift eyelids occasionally. Seek medical care if irritation persists.
Ingestion: Do not give anything by mouth to an unconscious person. Rinse mouth. Seek medical assistance without delay.
Most Important Symptoms and Effects: Drowsiness, blurred vision, delirium, difficulty urinating, rapid heartbeat. Risk of CNS toxicity with large exposures.
Notes to Physician: Provide symptomatic and supportive treatment. Monitor cardiovascular and CNS status.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Unsuitable Extinguishing Media: Straight streams of water may spread powder
Hazards Arising from Chemical: May emit toxic fumes of carbon monoxide, nitrogen oxides, hydrogen chloride during combustion
Special Protective Equipment and Precautions for Firefighters: Wear self-contained breathing apparatus and full protective gear
Fire/Explosion Risks: Powdered material may form combustible dust-air mixtures in large quantities
Specific Methods: Remove containers from fire area if possible without risk. Cool surrounding containers with water spray.
Personal Precautions: Avoid dust formation and inhalation. Use personal protective equipment including gloves, eye protection, and respirator if dust forms.
Environmental Precautions: Prevent entry into waterways, drains, or soil. Contain spill to smallest possible area.
Spillage & Cleanup Methods: Collect spilled product using moistened inert absorbent material. Avoid dry sweeping; use HEPA-filter vacuum or gentle wet methods. Place in closed, labeled waste containers for disposal. Ventilate area.
Decontamination Procedures: Wash spill site with soap and water after material pick-up.
Precautions for Safe Handling: Work in well-ventilated area. Prevent contact with skin, eyes, and clothing. Wash hands and face thoroughly after handling.
Hygiene Practices: Do not eat, drink, or smoke while using this material. Remove contaminated clothing and wash before reuse.
Conditions for Safe Storage: Store in tightly sealed container, in a cool, dry, well-ventilated location. Protect from light. Keep away from incompatible materials like strong oxidizers.
Storage Temperature: 15–30°C (59–86°F) recommended
Shelf Life: Maintain under recommended conditions for optimal stability.
Occupational Exposure Limits: No established OSHA or ACGIH limits for this compound; minimize exposure as with other pharmaceuticals
Engineering Controls: Use local exhaust ventilation or process enclosure when handling bulk powder
Personal Protection: Wear chemical-resistant gloves, laboratory coat, and safety goggles; use NIOSH-approved respirator if dust or aerosols are generated
Hygiene Measures: Wash skin thoroughly with soap and water after handling. Do not touch face, eyes, or mouth with contaminated gloves.
Environmental Exposure Controls: Avoid release into the environment. Implement measures to catch spillage or waste.
Appearance: White, odorless, crystalline powder
Odor: No detectable odor
Odor Threshold: Not established
pH (1% solution): About 5 (acidic)
Melting Point: 257–263°C (495–505°F)
Boiling Point: Decomposes upon heating
Flash Point: Not applicable
Solubility: Highly soluble in water; soluble in ethanol, insoluble in ether
Vapor Pressure: Not applicable (solid at ambient temperature)
Relative Density: 1.12 g/cm³
Partition coefficient (log Kow): Approx. 4.1
Viscosity: Not applicable
Explosive Properties: Not explosive under normal conditions
Oxidizing Properties: Not classified as an oxidizer
Chemical Stability: Stable under recommended storage and handling conditions
Reaction to Light: May degrade upon prolonged exposure to direct sunlight
Heat Stability: Decomposition occurs at high temperatures
Hazardous Polymerization: Does not occur
Conditions to Avoid: Extreme heat, moisture, direct sunlight, strong oxidizing agents
Incompatible Materials: Strong acids, strong oxidizers, reactive halogen compounds
Hazardous Decomposition Products: Hydrogen chloride gas, carbon monoxide, nitrogen oxides can form if heated to decomposition
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity (Oral, rat): LD50: 18 mg/kg (data varies by source)
Symptoms of Exposure: Dry mouth, blurred vision, tachycardia, restlessness, hallucinations with severe overdose
Long-Term Exposure: May result in cognitive impairment, increased risk of falls or confusion in elderly
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity / Teratogenicity: Some animal studies suggest developmental toxicity; no conclusive evidence in humans
Sensitization: Skin and respiratory sensitization possible
Other Data: Medical monitoring is advisable for workers with repeated occupational exposure
Ecotoxicity: Data on toxicity to aquatic organisms are limited; potential hazard due to pharmacological activity
Persistence and Degradability: May persist in the environment, moderate biodegradability reported
Bioaccumulation: Moderate potential, based on physicochemical properties
Mobility in Soil: May be moderately mobile if released
Other Adverse Effects: Avoid contamination of surface water due to unknown effects on aquatic and microbial species
Methods of Disposal: Treat as hazardous pharmaceutical waste; incineration recommended with flue gas scrubbing
Contaminated Packaging: Dispose of containers as hazardous waste after decontamination
Special Precautions for Disposal: Comply with local, regional, and national disposal regulations. Do not discharge to watercourses or sewer systems.
Disposal of Large Quantities: Consult licensed hazardous waste contractor or local environmental authority.
UN Number: Not classified under UN for regular shipping, special care and documentation required for bulk quantities
Proper Shipping Name: Trihexyphenidyl Hydrochloride
Transport Hazard Class: Not regulated under ADR, RID, IATA, IMDG for finished pharmaceutical product
Packing Group: Not assigned
Environmental Hazards: Not applicable in standard packaging; take care to prevent release during transit
Special Precautions for User: Ensure container integrity; document and track transport in accordance with rules for controlled substances where applicable
US Federal Regulations: Not specifically listed under RCRA, SARA 302/304, or SARA 313
OSHA Hazards: Toxic by ingestion, irritant
European Union (REACH): Not registered; substances for pharmaceutical use are exempt under certain conditions
Labeling Requirements: Hazardous substance symbol required on non-medicinal containers
Workplace Classification: Handle as hazardous drug per NIOSH guidelines
Other Regulations: Listed under controlled substances regulations in several jurisdictions; use by prescription only
Additional Notes: Observe occupational exposure limits and medicinal product handling laws in your country
