Material Safety Data Sheet for Thiophene-3-Ethanol

Identification

Product Name: Thiophene-3-Ethanol
Synonyms: 3-(2-Hydroxyethyl)thiophene
Chemical Formula: C6H8OS
CAS Number: 34847-42-6
Recommended Use: Laboratory chemical, synthesis of substances, research purposes only
Manufacturer Contact: Safety officer contact information, emergency phone number for immediate consultation
Emergency Overview: Pale yellow liquid, mild characteristic odor, mainly utilized in organic synthesis and specialized research labs

Hazard Identification

GHS Classification: Eye Irritant (Category 2), Skin Irritant (Category 2), Acute Toxicity-Oral (Category 4)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause skin irritation, harmful if swallowed
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing vapors or mist, wash hands thoroughly after handling, wear protective gloves, clothing, and eye protection, avoid ingestion
Potential Health Effects: Short contact with skin might cause irritation, inhalation of vapors brings headaches or respiratory discomfort, ingestion leads to nausea or abdominal pain, eye exposure often stings and reddens the area

Composition / Information on Ingredients

Chemical Name: Thiophene-3-Ethanol
Concentration: 97-100% pure
Common Impurities: Water below 1%, residual solvents below 1%
Other Identifiers: EC Number 252-492-3

First Aid Measures

Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, remove contact lenses if present and safe, seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash skin with mild soap and water for several minutes, see a physician if symptoms remain
Inhalation: Move victim to fresh air, keep at rest in position comfortable for breathing, seek medical help if breathing difficulties arise
Ingestion: Rinse mouth with water, do not induce vomiting, never give anything by mouth to an unconscious person, get medical advice
Advice for Doctors: Treat symptomatically based on clinical judgment

Fire-Fighting Measures

Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide, water spray for cooling containers not involved in fire
Specific Hazards: Vapors can form explosive mixtures with air, combustion may release sulfur oxides and other toxic gases
Protective Equipment: Full protective gear, self-contained breathing apparatus for fire-fighters
Advice: Evacuate area, keep fire-exposed containers cool using water spray, prevent fire run-off from contaminating water sources

Accidental Release Measures

Personal Precautions: Ventilate area, remove all sources of ignition, wear suitable protective clothing, gloves, goggles
Environmental Precautions: Prevent spillage from entering water bodies, drains, or soil
Spill Cleanup Methods: Absorb with inert dry material such as sand or earth, collect in appropriate waste container, dispose in accordance with regulations
Additional Actions: Decontaminate area with soap and water after cleanup, wash hands thoroughly

Handling and Storage

Precautions for Safe Handling: Handle in well-ventilated place, avoid skin and eye contact, prevent ingestion or inhalation
Storage Conditions: Store tightly closed in cool, dry, well-ventilated location away from incompatible substances like oxidizers and acids
Maximum Storage Temperature: 25°C
Recommended Storage Container: Amber glass bottles or approved chemical containers with proper labeling
Special Handling Instructions: Bond and ground containers when transferring, use safety cabinets where large volumes are stored

Exposure Controls and Personal Protection

Engineering Controls: Local exhaust ventilation, fume hood for significant quantities, emergency eye wash stations in immediate area
Personal Protective Equipment: Nitrile gloves, chemical splash goggles, lab coat, closed-toe shoes
Respiratory Protection: Chemical cartridge respirator if airborne exposure risk is present
Hygiene Measures: Wash hands and face before breaks and at end of work, avoid contaminated clothing

Physical and Chemical Properties

Appearance: Pale yellow to colorless liquid
Odor: Distinct, mild aromatic
Boiling Point: 227°C
Melting Point: Data not widely reported, remains liquid at room temperature
Flash Point: 104°C
Solubility: Miscible with organic solvents such as ethanol, DMSO, poorly soluble in water
Vapor Pressure: Low at ambient temperature
Density: Approximately 1.16 g/cm³
pH: Not applicable for non-aqueous liquid
Partition Coefficient (Log Pow): Estimated at 1.1

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions.
Conditions to Avoid: Heat, ignition sources, static discharge, open flames
Incompatible Materials: Strong oxidizers, strong acids
Hazardous Decomposition Products: Sulfur oxides, carbon oxides, toxic organic fumes formed on combustion or thermal decomposition
Polymerization: No hazardous polymerization expected under normal conditions

Toxicological Information

Acute Toxicity: Oral LD50 (rat): estimated at 640 mg/kg
Skin Corrosion/Irritation: Causes moderate irritation on repeated or prolonged contact
Serious Eye Damage/Irritation: Stings, redness, tearing potential
Respiratory Sensitization: Vapor inhalation causes headache, dizziness, or mild respiratory irritation
Carcinogenicity: No carcinogenic effects observed in standard tests
Mutagenicity: Not expected based on current structure-activity relationships
Other Data: Prolonged exposure might sensitize skin; symptoms resolve with standard medical aid

Ecological Information

Ecotoxicity: Harmful to aquatic life in high concentrations, low volatility reduces environmental mobility
Persistence and Degradability: Expected to biodegrade slowly, not readily bioaccumulative
Bioaccumulation Potential: Low based on measured partition coefficient
Mobility in Soil: Moderate, substance binds to soil particles under most environmental conditions
Other Adverse Effects: Avoid release to the environment; regulated disposal required for large-scale spillage

Disposal Considerations

Product Disposal: Incinerate in approved chemical waste facility, follow all local and national regulations
Contaminated Packaging: Rinse with compatible solvent, offer for chemical recycle or disposal through licensed waste handler
Special Considerations: Avoid direct discharge; never pour into drains or surface water.

Transport Information

UN Number: Not classified as a dangerous good for transport by air, sea, or road
Proper Shipping Name: Chemical, not otherwise specified (Thiophene-3-Ethanol)
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Avoid spillage during transport; follow spill response measures in case of leakage
Transport Precautions: Keep away from food and animal feed, store upright and secure during transit

Regulatory Information

TSCA Status: Listed in United States Toxic Substances Control Act Inventory
REACH Status: Not fully registered in European Union REACH regulation
OSHA Hazards: Eye and skin irritant
SARA Title III: Not subject to reporting under sections 302, 304, 313
Other Regulations: Not regulated as a hazardous material under US DOT, IMDG, or IATA standards
Worker Protection: Employee training and hazard communication plans should include properties and risks, chemical hygiene plan coverage for laboratories