Product Name: Thiomorpholine
Chemical Name: 1-Thia-4-azacyclohexane
Synonyms: Tetrahydro-1,4-thiazine
CAS Number: 123-90-0
Recommended Use: Intermediate in chemical synthesis, solvent
Supplier Details: Include address, phone number, emergency contact
Emergency Phone Number: Chemtrec or local number for immediate support
GHS Classification: Flammable liquid (Category 3), Acute toxicity oral (Category 4), Acute toxicity dermal (Category 3), Acute toxicity inhalation (Category 3), Skin corrosion/irritation (Category 2), Eye irritation (Category 2A)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, fatal in contact with skin, toxic by inhalation, causes skin and eye irritation, may catch fire
Pictograms: Flame, Skull and Crossbones, Exclamation Mark
Precautionary Statements: Avoid breathing vapor or mist, use personal protective equipment as required, no eating or drinking while handling, keep away from ignition sources
Potential Health Effects: Contact can cause burns, inhalation leads to respiratory tract irritation or distress, eye exposure brings severe stinging and redness
Chemical Identity: Thiomorpholine
Content: ≥99%
Impurities: Minor impurities from synthesis, residual starting materials less than 1%
Molecular Formula: C4H9NS
Molecular Weight: 103.19 g/mol
Eye Contact: Flush with plenty of water for at least fifteen minutes, force eyelids apart to rinse thoroughly, seek medical attention right away
Skin Contact: Remove contaminated clothes, wash affected area under running water with soap for at least fifteen minutes, immediate medical support recommended especially if irritation develops
Ingestion: Do not induce vomiting, rinse mouth carefully, get medical help as quickly as possible, provide chemical name to health professionals
Inhalation: Move to fresh air with no delay, avoid self-exposure, if breathing is difficult provide oxygen, maintain open airway, urgent medical intervention essential
Most Immediate Symptoms: Burning sensation in eyes or nose, excessive tearing, difficulty in breathing, nausea or severe coughing
Suitable Extinguishing Media: Carbon dioxide, dry chemical, alcohol-resistant foam, large amounts of water if necessary
Hazardous Combustion Products: Sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide
Specific Fire Hazards: Vapors may form explosive mixtures with air, can travel along surfaces to ignition sources
Protective Equipment for Firefighters: Full face self-contained breathing apparatus, complete protective clothing including gloves and boots
Special Procedures: Remove containers from fire area if safe, cool containers with water to prevent pressure buildup, avoid inhaling fumes
Personal Precautions: Put on chemical resistant gloves, full goggles, use respirator if ventilation lacks, keep bystanders away
Environmental Precautions: Prevent entry into drains, waterways, or soil, contain spill using inert absorbents such as sand or vermiculite
Cleanup Methods: Absorb spill with appropriate non-combustible material, gather residue into labelled containers for disposal, wash spill site after collection, ventilate room thoroughly
Additional Measures: Secure area to limit exposure, report major spills to relevant authorities, avoid touching contaminated surfaces with bare hands
Safe Handling: Wear protective gloves, face shield, lab coat, use only in well-ventilated space, avoid breathing fumes or vapors, prohibit eating or drinking in handling area
Storage Conditions: Store in tightly closed container, in a dry, well-ventilated storage area, away from heat sources, oxidizers, acids, or any ignition points, label storage clearly
Additional Practices: Spill kits should stay within reach, maintain eye-wash fountains and emergency showers nearby, segregate from incompatible materials like strong oxidizers or acids
Maintenance Requirements: Check storage containers regularly for leaks, update inventory logs, restrict access to trained personnel only
Exposure Limits: Workplace standards for thiomorpholine are not universally established; treat as hazardous when uncertainty exists
Engineering Controls: Use chemical fume hood, maintain efficient local exhaust, install mechanical ventilation in confined spaces
Respiratory Protection: Select respirator suitable for concentration and type of exposure, filter cartridges for organic vapors
Hand Protection: Nitrile or neoprene gloves, discard after contact or spills
Eye/Face Protection: Chemical splash goggles and full-face shield suggested
Body Protection: Lab coat, use apron for bulk handling, close-fitting sleeves
Hygiene Measures: Wash hands before meals or smoking, immediate laundering of contaminated clothing
Appearance: Clear, colorless liquid
Odor: Strong, unpleasant (sulfurous)
pH: Not available (depends on solution strength)
Melting Point: -4°C
Boiling Point: 166°C
Flash Point: 55°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable, vapor can catch fire above flash point
Vapor Pressure: 5 mmHg at 25°C
Vapor Density: 3.6 (air=1)
Solubility: Miscible with water
Partition Coefficient (n-octanol/water): Not determined
Specific Gravity: 1.08 at 20°C
Viscosity: Not available
Chemical Stability: Remains stable under recommended storage conditions, prolonged heat or light exposure decreases shelf life
Incompatible Materials: Strong acids, oxidizers, bleach, peroxides
Hazardous Decomposition: Generates harmful gases—sulfur oxides and nitrogen oxides—if heated to decomposition
Possibility of Hazardous Reactions: Unsafe reaction with oxidizing agents, reacts with acids liberating heat or toxic vapors
Conditions to Avoid: Sources of ignition, elevating temperature, contact with incompatible substances
Routes of Exposure: Skin contact, inhalation, ingestion, mucous membrane exposure
Acute Toxicity: LD50 (oral, rat) ~110 mg/kg, highly toxic in contact with skin, inhalation can produce convulsions or respiratory distress
Chronic Effects: May affect liver or kidneys with repeated exposure, persistent skin exposure can cause dermatitis, chronic inhalation might lead to asthma-like symptoms
Symptoms of Overexposure: Burning sensation, coughing, headache, dizziness, nausea, tremors, skin redness
Carcinogenicity: Not classified as carcinogen by NTP, IARC, or OSHA
Other Data: Sensitization with repeated exposure not well studied, possible mutagenic effects not fully ruled out
Aquatic Toxicity: Harmful to aquatic organisms, limited studies suggest moderate risk to fish and invertebrates
Persistence and Degradability: Degrades in environment but breakdown products may retain toxicity
Bioaccumulation Potential: Low potential based on molecular structure
Soil Mobility: Moves readily in moist soils, may reach groundwater
Other Environmental Hazards: Avoid uncontrolled release to surface water, soil, or sewers, possible odor complaints if vapors escape
Waste Disposal: Collect waste in tightly sealed containers, use licensed chemical waste disposal services
Disposal of Packaging: Triple rinse containers, puncture to prevent re-use, dispose with chemical waste
Regulatory Policies: Never pour down drain or in regular trash, follow local hazardous waste regulations
Recycling/Reclamation: Not recommended due to toxicity
UN Number: 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains Thiomorpholine)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Special Precautions: Use leak-proof, shock-resistant containers, include emergency contact and hazard pictograms, restrict carriage with food items, notify all carriers of risks
Regulatory Transport Guidance: Comply with IATA, IMDG, DOT protocols
Classification under GHS: Covered under acute toxicity and flammability hazards
OSHA Status: Hazardous chemical, subject to workplace right-to-know standards
SARA Title III Sections 311/312: Classified—immediate (acute) health hazard
TSCA Inventory: Present
EINECS/ELINCS Number: 204-649-6
Other Regulations: Subject to chemical accident prevention, regional workplace exposure monitoring
Labelling for Supply: Must carry hazard pictograms and signal word, include emergency procedures and first aid on container labels
