Chemical Name: Thiazole-4-Carboxylic Acid
Synonyms: 4-Thiazolecarboxylic acid, Thiazol-4-carboxylic acid
CAS Number: 3973-08-8
Use: Primarily intended for laboratory research and chemical synthesis, serves as a building block in pharmaceutical compounds and intermediate in fine chemical production
Supplier Details: Check product packaging for manufacturer address and emergency phone number; consult distributor label or supplier website
Emergency Contact: Refer to local Poison Control Center and manufacturer hotline for immediate steps in event of exposure or spill
GHS Classification: Irritant, may cause skin and eye irritation, can trigger respiratory tract discomfort on repeated exposure
Symbol: Exclamation mark for acute toxicity and irritation
Hazard Statements: Irritating to eyes, skin, and respiratory system; avoid dust inhalation, limit skin contact
Precautionary Statements: Wear gloves and goggles, do not touch face during handling, seek fresh air if powder is inhaled
Potential Health Effects: Short-term irritation to respiratory tract and eyes after contact; chronic exposure data is limited, so prolonged or repeated exposure not recommended
Chemical Identity: Thiazole-4-Carboxylic Acid
Formula: C4H3NO2S
Concentration: 98+% active ingredient, minor impurities possible from synthesis
Impurities: Minimal, primarily arising from synthesis process, typically less than 2% by weight; no significant byproducts likely
Inhalation: Move affected person outside into fresh air as soon as possible, loosen tight clothing, seek medical help if symptoms like coughing or throat irritation persist
Eye Contact: Rinse with cool running water for 15 minutes, keep eyelids open, seek medical advice if any irritation or blurred vision remains
Skin Contact: Wash area thoroughly with mild soap and warm water, remove contaminated clothing, consult a healthcare provider for persistent rash or redness
Ingestion: Rinse mouth thoroughly, never induce vomiting unless directly advised by medical personnel, contact Poison Control or physician for guidance
Suitable Extinguishing Methods: Use water spray, carbon dioxide, dry chemical powder, or foam extinguishers
Specific Dangers: Combustion can release toxic fumes including oxides of sulfur, nitrogen, and carbon; avoid inhalation of smoke
Protective Equipment: Firefighters should wear self-contained breathing apparatus, full protective gear
Precautions: Remove all nearby chemicals, avoid contamination of extinguishing water by collecting runoff, ventilate area after fire
Personal Protection: Wear dust mask, chemical-resistant gloves, goggles; prevent skin and respiratory exposure to powders
Spill Clean-Up: Scoop up with non-sparking tools, sweep residue carefully to avoid dust clouds, place into sealed chemical waste container
Ventilation: Ensure open or mechanical ventilation during clean-up operation
Reporting: For large spills, notify local authorities and follow institutional protocols
Environmental Protection: Prevent entry to waterways, drains, and soil; clean tools thoroughly after handling spills
Safe Handling: Avoid contact with skin and eyes, minimize dust formation, handle only in well-ventilated areas, refrain from eating or smoking while working
Storage Conditions: Keep container tightly sealed, store in a cool, dry, and well-ventilated space away from heat sources, limit exposure to direct sunlight
Incompatibilities: Keep away from strong bases, oxidizing agents, and incompatible chemicals identified in SDS literature
Hygiene Measures: Wash hands and forearms thoroughly after handling, clean work surfaces regularly to remove powder residues
Exposure Limits: No specific occupational exposure limits set by OSHA or ACGIH, but minimize inhalation and skin contact as a precaution
Engineering Controls: Use chemical fume hood for bench-scale work, install local exhaust or process enclosures for larger scale operations
Personal Protective Equipment: Wear safety goggles, nitrile gloves, lab coat, and dust mask during handling
Environmental Exposure Controls: Contain all spills, properly dispose of waste, never pour residues down drains
Appearance: Pale yellow to off-white crystalline powder, free-flowing under dry conditions
Odor: Practically odorless
pH (in solution): Slightly acidic in water
Melting Point: Approximately 225-230°C, decomposes on heating
Boiling Point: Data unavailable, compound undergoes decomposition before boiling
Solubility: Slightly soluble in water, more freely soluble in organic solvents such as methanol and ethanol
Density: Around 1.54 g/cm³
Vapor Pressure: Negligible under standard conditions
Partition Coefficient: log Kow data not established
Chemical Stability: Remains stable under normal laboratory storage and use, decomposes at elevated temperatures
Reactivity: Avoid mixing with strong oxidizers or bases—may trigger decomposition or undesirable side reactions
Decomposition: Heating to breakdown releases toxic gases such as carbon monoxide, sulfur oxides, nitrogen oxides
Incompatible Materials: Alkali metals, strong acids, chlorinating agents
Hazardous Polymerization: Not expected under recommended storage and use
Routes of Exposure: Eyes, skin, inhalation, ingestion
Acute Toxicity: Low to moderate for skin and respiratory tract irritation, severity depends on exposure amount
Chronic Toxicity: No long-term studies in humans, repeated or massive exposure could sensitize skin or respiratory tract
Symptoms: Redness, itching, coughing, watery eyes, burning sensation if mishandled
Carcinogenicity: Current research does not classify compound as a carcinogen, but appropriate safety steps reduce unnecessary risks
Other Effects: No known reproductive or organ toxicity at occupational exposure levels
Aquatic Toxicity: Information scarce, similar compounds suggest some aquatic toxicity, best to prevent release into environment
Persistence and Degradability: Compound likely persists in soil and water, slow degradation
Bioaccumulative Potential: Low expected, insufficient empirical data, but prudent to keep out of ecological systems
Mobility in Soil: Moderate mobility predicted, could reach groundwater on significant spill
Other Adverse Effects: No known destruction of ozone layer, unsuitable for direct disposal in water bodies
Waste Disposal Methods: Gather all unwanted material and contaminated items in tightly sealed containers coded for hazardous organic waste
Do Not Release: Avoid disposal in landfill, stormwater, or natural water courses
Incineration: Preferred method under controlled conditions at licensed facility using approved technology
Consult Regulators: Follow national and local chemical waste management regulations; consult environmental health and safety office
UN Number: Not classified as a hazardous material for ground, sea, or air transport under normal packing
Shipping Name: Thiazole-4-Carboxylic Acid (non-hazardous for most forms of carriage)
Hazard Class: No specific class assigned, but routine caution during transportation prevents spills
Packing Group: Usually Category III for non-flammable solids
Special Precautions: Protect from excess heat, rough handling; use original or equivalent leak-proof packaging
Label Requirements: GHS compliant label with hazard pictogram, signal word, and emergency advice
TSCA (USA): Compound typically listed, check supplier certification
REACH (EU): Import and handling above specified thresholds require registration
Other Regulations: Follows OSHA, WHMIS, GHS, and region-specific hazard communication standards
Restrictions: Satisfy workplace chemical inventories, training, and reporting per local law before use or disposal
