Product Name: Thiamazole
Synonyms: Methimazole, 1-methyl-3H-imidazole-2-thione
CAS Number: 60-56-0
Molecular Formula: C4H6N2S
Molecular Weight: 114.17 g/mol
Recommended Use: Antithyroid drug for hyperthyroidism
Manufacturer Details: Refer to supplier or distributor documents for specific contacts
Emergency Contact: Use national poison control centers, local emergency lines, or company-specific 24-hour hotlines
GHS Classification: Acute Toxicity – Oral (Category 3); Skin Sensitizer (Category 1); Specific Target Organ Toxicant – Repeated Exposure (Category 2)
Pictograms: Skull and crossbones, exclamation mark, health hazard
Signal Word: Danger
Hazard Statements: Fatal if swallowed; May cause allergy or asthma symptoms or breathing difficulties if inhaled; Causes damage to organs through prolonged or repeated exposure
Precautionary Statements: Avoid breathing dust; Wash skin thoroughly after handling; Do not eat, drink, or smoke near product; Wear protective gloves, eye protection, and face protection
Name: Thiamazole
Purity: >98% by weight (depending on supplier template)
Impurities: None above threshold level for classification
Other Components: None included for standard laboratory or medical grade unless specified by supplier
Inhalation: Remove to fresh air. Keep individual at rest. Seek medical attention if symptoms continue. If breathing stops, provide artificial respiration.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water for at least fifteen minutes. Consult a physician if irritation develops.
Eye Contact: Hold eyelids apart. Rinse with clean, lukewarm running water for at least fifteen minutes. Seek specialist attention if discomfort persists.
Ingestion: Rinse mouth. Do not induce vomiting. If individual is conscious, provide water to drink. Seek immediate medical help.
Emergency Symptoms: Signs can include sore throat, nausea, allergic reaction, or respiratory distress depending on exposure route and amount.
Suitable Extinguishing Media: Water spray, carbon dioxide, foam, dry chemical powder
Special Hazards: May emit toxic fumes of sulfur oxides, nitrogen oxides, and carbon oxides under combustion
Protective Equipment: Wear self-contained breathing apparatus and flame-resistant protective clothing
Fire Precautions: Cool containers exposed to flame with water spray to avoid rupture; move containers from fire area if safe; prevent contamination of drains or watercourses by run-off
Personal Precautions: Use appropriate respiratory protection. Prevent skin and eye contact by using gloves and splash goggles. Isolate spill area to only necessary personnel.
Environmental Precautions: Prevent material from entering surface water, drains, or soil. Avoid contamination by keeping contained.
Cleanup Methods: Sweep up or vacuum spilled material using non-sparking tools. Place into suitable, tightly closed containers. Clean affected area thoroughly with soap and water. Dispose of as hazardous waste.
Handling: Ensure use in well-ventilated areas or fume hood. Wear suitable disposable gloves, protective clothing, and face protection. Do not eat, drink, or smoke while handling. Prevent release to environment.
Storage: Store in a tightly closed, labelled container. Keep away from incompatible agents like oxidizers and acids. Maintain at room temperature, in a cool, dry, well-ventilated space. Protect from light and moisture. Restrict access to trained personnel only.
Engineering Controls: Use chemical fume hood, local exhaust, or equivalent system to minimize airborne concentrations.
Personal Protective Equipment: Gloves made from nitrile or latex for hands, safety goggles or face shield for eyes, lab coat or apron for body protection.
Respiratory Protection: If dust, mist, or vapor formation, use NIOSH-approved respirators specifically for chemical particulate protection.
Hygiene Measures: General industrial hygiene practice, including washing hands before breaks or eating, removing contaminated clothes, and not allowing product on skin, eyes, or clothing.
Occupational Exposure Limits: No established OSHA or ACGIH exposure limits, but minimize exposure by established industrial safety practice.
Appearance: White to off-white crystalline powder
Odor: Faint, sulfurous
Odor Threshold: Not available
pH: Neutral in solution
Melting Point: 146–151°C
Boiling Point: Data not available (decomposes before boiling)
Flash Point: Not applicable
Decomposition Temperature: Above melting point
Solubility: Soluble in water and alcohol
Vapor Pressure: Negligible at room temperature
Density: ~1.27 g/cm³
Partition Coefficient (n-octanol/water): Not available
Evaporation Rate: Not determined
Viscosity: Not applicable
Chemical Stability: Stable under standard storage and handling conditions
Reactivity: Not reactive with most materials under standard conditions
Incompatible Materials: Strong oxidizers, strong acids, alkali metals
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon oxides under thermal decomposition
Hazardous Polymerization: No reports of hazardous polymerization; not expected to occur
Conditions to Avoid: Heat, flames, moisture, direct sunlight
Acute Toxicity: Oral LD50 (rat): 75–130 mg/kg
Symptoms of Exposure: May cause headache, drowsiness, gastrointestinal discomfort, allergic reaction, rash, or, rarely, blood disorders
Skin and Eye Contact: Sensitization possible; may irritate or cause allergic dermatitis
Chronic Effects: Prolonged exposure can impair liver function and disrupt normal immune response; potential for hematological toxicity (agranulocytosis)
Carcinogenicity: Not classified by NTP, IARC, or OSHA as cancer-causing
Mutagenicity: Not known to cause inheritable genetic damage
Reproductive Toxicity: Teratogenic effects reported in animals at high doses; use with precaution in pregnancy
Aquatic Toxicity: Moderate risk to aquatic organisms; studies show effective concentration (EC50) in algae, Daphnia, or fish varies between 1–100 mg/L
Persistence and Degradability: Product degrades slowly in water and soil; persistent in environment if released in quantity
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: Water soluble; can move through soil with surface runoff
Other Ecological Effects: Discharged material may affect aquatic life and microbial action in sewage treatment; avoid direct release into environment
Waste Disposal Methods: Treat as hazardous chemical waste; collect and store in sealed containers for proper disposal by licensed hazardous waste handler.
Disposal of Containers: Empty containers may retain residues; triple rinse and manage as hazardous waste.
Recommendation: Do not pour down drain, sewer, or into the environment.
Relevant Regulations: Disposal must comply with local, regional, and national environmental legislation and guidelines.
DOT (US): Not regulated for ground transportation
IMDG (Sea): Not classified as marine pollutant; observe general chemical transport precautions
IATA (Air): Not regulated but pack to prevent spillage and exposure
Packaging Requirements: Secure, labelled, sealed containers. Prevent release of dust or product during shipping.
Transport Precautions: Avoid shipping with incompatible chemicals such as oxidizers.
OSHA: Not classified as hazardous under OSHA Hazard Communication Standard (29 CFR 1910.1200), but recommended to treat as hazardous due to toxicity
TSCA: Listed in US Toxic Substances Control Act Inventory
REACH (EU): Registered under REACH; handle as Substances of Very High Concern (SVHC) are possible due to toxicity profile
SARA Title III: No specific hazards associated, but inclusion possible in Section 313 reporting if handled in large volumes
California Proposition 65: Not listed
WHMIS (Canada): Classified as D2A – Very toxic material causing other toxic effects
Other National/Local Regulations: Consult country-specific requirements for handling and environmental discharge as they may vary
