Product Name: Tetryzoline
Chemical Name: 2-(1,2,3,4-Tetrahydro-1-naphthyl)imidazoline
Common Names: Tetrahydrozoline, Tetryzoline Hydrochloride
CAS Number: 84-22-0
Relevant Uses: Pharmaceutical, ophthalmic solutions, nasal sprays
Manufacturer/Supplier Identification: Contact information available on commercial packaging or supplier’s documentation
Emergency Contact: Chemtrec (24/7) or local poison control
GHS Classification: Acute Toxicity (Oral) Category 3, Eye Irritation Category 2A, Specific Target Organ Toxicity (Single Exposure) Category 2
Hazard Pictograms: Exclamation mark, health hazard
Signal Word: Danger
Hazard Statements: Toxic if swallowed, causes serious eye irritation, may cause drowsiness or dizziness, risk of adverse effects to central nervous system
Precautionary Statements: Avoid breathing dust/fumes/gas/mist/vapors/spray, wash hands thoroughly after handling, do not eat/drink/smoke while handling, wear protective gloves/eye protection
Chemical Identity: Tetryzoline Hydrochloride
Concentration: Typically 100% pure in laboratory samples, variable in commercial preparations
Impurities/Additives: Manufacturing byproducts or residual solvents traceable by certificate of analysis
Other Components: Commercial solutions may contain excipients, buffers, or preservatives depending on product formulation
Molecular Formula: C13H16N2 · HCl
Molecular Weight: 241.74 g/mol
Inhalation: Move affected individual to fresh air, monitor for respiratory distress, seek medical attention if symptoms develop
Ingestion: Immediate medical attention is necessary—do not induce vomiting, rinse mouth if person is conscious
Skin Contact: Remove any contaminated clothing, rinse skin with water for at least 15 minutes, seek help if irritation appears
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if possible, continue rinsing, obtain prompt medical care
Most Important Symptoms: Drowsiness, low blood pressure, irregular heartbeat, hypotonia, coma in severe poisoning
Advice for Physician: Symptomatic and supportive treatment, monitor vital signs, beware of central nervous system depression, consider activated charcoal in acute cases
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Unsuitable Media: Do not use high pressure water streams, which may spread material
Specific Hazards: May form toxic fumes under fire, including nitrogen oxides, carbon monoxide, hydrochloric acid vapor
Protective Equipment for Fire-Fighters: Self-contained breathing apparatus, full protective gear to prevent inhalation of combustion gases
Fire-Fighting Procedures: Move containers from fire area if safely possible, cool closed containers with water spray, prevent runoff from entering water supplies or environment
Personal Precautions: Wear suitable protective clothing, gloves, goggles, avoid dust formation and inhalation
Environmental Precautions: Prevent spillage from entering drains, surface water, or groundwater systems
Methods for Clean-Up: Sweep or vacuum spilled material into a suitable container for disposal, wash contaminated area with water and detergent, ventilate area once spill is contained
Special Spill Handling: Biological waste protocols if contaminated with human material, avoid raising dust, use non-sparking tools
Handling: Store in original container, handle in a well-ventilated place, minimize dust generation, avoid skin and eye contact, ensure containers are tightly closed after use
Storage: Keep at controlled room temperature (15–30°C), protect from moisture and light, segregate from incompatible materials such as strong oxidizers and acids
Storage Conditions: Secure in storage area with secondary containment if handling bulk quantities, restrict access to trained personnel
Engineering Controls: Local exhaust ventilation, eyewash stations and safety showers in work area
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH or NIOSH at this time
Personal Protection: Chemical-resistant gloves (nitrile or neoprene), safety goggles, laboratory coat or protective clothing
Respiratory Protection: Use NIOSH-approved respirator in the absence of sufficient ventilation
Hygiene Measures: Remove contaminated clothing, wash hands thoroughly after handling, keep food away from work area
Appearance: White crystalline powder
Odor: Odorless
Melting Point: 250-254°C (decomposes)
Boiling Point: Data not available—compound decomposes on heating
Solubility: Freely soluble in water, soluble in ethanol, slightly soluble in chloroform
pH: Acidic in solution
Vapor Density: Not determined
Evaporation Rate: Not applicable, non-volatile solid
Partition Coefficient (log Kow): ~2.0 estimated
Flash Point: Not flammable
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: Not expected under normal conditions, avoid strong oxidizers and acids
Decomposition Products: Nitrogen oxides, hydrochloric acid, carbon monoxide, carbon dioxide if heated or burned
Conditions to Avoid: Strong heat, open flame, extended exposure to light
Reactivity: Inert under standard conditions; not known to polymerize or explode
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): 165 mg/kg; LD50 (oral, mouse): 85 mg/kg
Effects of Short-term Exposure: Drowsiness, hypotension, bradycardia, hypothermia, potential CNS depression
Effects of Long-term Exposure: Rare in occupational settings, chronic misuse can disrupt cardiovascular and nervous systems
Sensitization: Not reported
Carcinogenicity/Mutagenicity: Not listed as carcinogen by IARC, NTP, OSHA; animal studies limited
Reproductive Toxicity: Data insufficient, avoid exposure during pregnancy
Ecotoxicity: Harmful to aquatic organisms, may cause long term adverse effects in the aquatic environment
Persistence and Degradability: Likely biodegradable over long periods, but specific rate is unclear due to limited data
Bioaccumulative Potential: Low to moderate potential; log Kow suggests some accumulation in biota may occur
Mobility in Soil: Fairly mobile due to water solubility; can contaminate water sources
Other Adverse Effects: Unused solutions and bulk powder must not enter wastewater systems
Disposal Method: Collect and dispose through licensed hazardous waste processor, in accordance with local, state, and federal regulations
Container Disposal: Triple rinse, render container unusable, dispose with lab plastics, or as hazardous solid waste
Contaminated Packaging: Treat as hazardous chemical waste, ensure no leaks or residues enter public landfill or incinerator without permit
Waste Code: US EPA hazardous waste: Not assigned a unique code but may be regulated by other jurisdictions
UN Number: Not specifically listed; may travel under UN3249 (Medicines, solid, toxic, n.o.s.) when shipping large quantities
Proper Shipping Name: Tetryzoline or pharmaceutical preparation containing tetrahydrozoline
Hazard Class: 6.1 (Toxic substance)
Packing Group: III (if applicable)
Marine Pollutant: Not listed as marine pollutant in current ADR/IMDG codes
Transport Labels Required: Toxic substance label
Special Transport Precautions: Store in tightly sealed and labeled containers, avoid rough handling, protect from moisture during shipments, document chain of custody for regulated drug transport
Recommended Regulations: Handled according to OSHA laboratory standard, U.S. EPA hazardous chemical laws, and European Commission rules for dangerous substances
TSCA Status: Included on US Toxic Substances Control Act Inventory
EU Inventory: Listed on EINECS/ELINCS under EC Number 201-517-6
Controlled Substance Status: Not a scheduled drug in United States, regulated as prescription medicine, subject to additional controls for pharmaceutical distribution
Workplace Labelling: Comply with GHS/OSHA hazardous communication standards
Additional Information: Product safety sheet and workplace training required for all handlers; regular updates and audits may apply in research or hospital settings
