Product Name: Tetrahydropyrrole
Synonyms: Pyrrolidine
Chemical Formula: C4H9N
CAS Number: 123-75-1
Recommended Use: Used as an intermediate in organic synthesis, especially in pharmaceuticals, agrochemicals, and polymer manufacturing
Manufacturer: Identified on product label
Emergency Contact: Available through the local distributor or manufacturer, generally found on label and shipping papers
GHS Classification: Flammable Liquids (Category 3), Acute Toxicity Oral (Category 3), Acute Toxicity Dermal (Category 3), Serious Eye Damage/Eye Irritation (Category 2A), Specific Target Organ Toxicity Single Exposure (Category 3, Narcotic Effects)
Signal Word: Danger
Hazard Statements: Flammable liquid and vapor; toxic if swallowed or in contact with skin; causes serious eye irritation; may cause respiratory irritation; may cause drowsiness or dizziness
Precautionary Statements: Avoid all unnecessary exposure; Keep away from heat and open flames; Wear protective gloves, clothing, and eye protection; Wash hands thoroughly after handling
Substance: Tetrahydropyrrole
Concentration: 99% or higher
Impurities: Water (<1%), manufacturing by-products (<0.5%)
Molecular Weight: 71.12 g/mol
Inhalation: Move to fresh air, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Rinse affected area with plenty of water and remove contaminated clothing, wash with mild soap, seek medical advice for any persistent irritation
Eye Contact: Flush with water for at least 15 minutes lifting eyelids occasionally, remove contact lenses if safe, get prompt medical evaluation
Ingestion: Do not induce vomiting, rinse mouth thoroughly, seek professional medical care immediately
Symptoms: May include dizziness, headache, nausea, skin or eye irritation, confusion or unconsciousness in severe cases
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Special Hazards: Vapors may form explosive mixtures with air, hazardous gas formations (NOx) possible under fire conditions
Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Advice: Use water spray to cool containers, avoid inhaling combustion products which could include nitrogen oxides and carbon monoxide
Personal Precautions: Wear chemical-resistant gloves, safety goggles, and protective clothing, ensure adequate ventilation, avoid breathing vapors
Environmental Precautions: Prevent entry into drains, sewers, or waterways, contain spill with absorbents like vermiculite or sand
Cleanup Methods: Collect liquid or absorbed material in suitable container for disposal, ventilate area, wash spill site after material pickup
Reporting: Follow local regulations for environmental release reporting
Handling: Handle in a well-ventilated space, wear appropriate PPE during transfer, avoid inhalation and contact with skin or eyes
Storage Conditions: Store in tightly closed containers, in a cool and dry place away from heat, ignition sources, and incompatible chemicals such as acids and oxidizers
Technical Measures: Use explosion-proof electrical equipment, employ local exhaust ventilation at points of vapor emission, ground storage containers properly
Occupational Exposure Limits: OSHA PEL: 1 ppm (Skin); ACGIH TLV: 1 ppm (Skin)
Engineering Controls: Provide local exhaust ventilation, use closed systems when possible, regularly test air for vapor levels
Personal Protective Equipment: Chemical splash goggles, impervious gloves (nitrile or neoprene), flame-resistant lab coat, chemical-resistant shoes
Hygiene: Change contaminated clothing immediately, avoid eating or drinking in work area, thoroughly wash hands before breaks or leaving
Appearance: Colorless to pale yellow liquid
Odor: Ammonia-like, fishy
Melting Point: -63°C
Boiling Point: 87°C
Flash Point: 23°C (closed cup)
Auto-Ignition Temperature: 325°C
Vapor Pressure: ~37 mmHg at 25°C
Solubility: Miscible with water and most organic solvents
Density: 0.866 g/cm³ at 20°C
pH: Alkaline (pH > 11 in aqueous solution)
Evaporation Rate: Rapid under normal conditions
Stability: Stable under recommended storage and handling conditions
Reactivity: Reacts vigorously with strong acids, oxidizing agents, and acid chlorides
Hazardous Decomposition: Possible formation of carbon monoxide, carbon dioxide, nitrogen oxides under fire or extreme heat
Polymerization: Not known to polymerize under normal conditions
Conditions to Avoid: Heat, open flames, sources of ignition, contact with incompatible materials
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat) ~300 mg/kg; Dermal LD50 (rabbit) ~500 mg/kg
Inhalation: May cause headache, nausea, respiratory tract irritation, CNS depression
Skin Contact: Can cause severe irritation, potential chemical burns with prolonged exposure
Eye Contact: Severe irritation, redness, possible vision impairment with splash exposure
Chronic Effects: Repeated exposure may cause liver or kidney damage; potential sensitization is unresolved
Carcinogenicity: Not classified as carcinogenic under IARC, NTP, or OSHA standards
Additional Information: No known reproductive toxicity or mutagenicity based on available animal studies
Aquatic Toxicity: Moderate toxicity to aquatic organisms; LC50 (fish, 96 hr): ~68 mg/L
Persistence and Degradability: Moderately biodegradable by natural aquatic microorganisms
Bioaccumulative Potential: Low, due to rapid degradation and low partition coefficient
Mobility: High mobility in soil and water due to complete miscibility with water
Other Effects: High concentrations may cause algal blooms or aquatic imbalance; avoid release to environment
Waste Treatment: Dispose in accordance with federal, state, and local environmental regulations
Methods: Use a licensed waste disposal contractor, incinerate in a chemical incinerator with afterburner and scrubber for gaseous emissions
Container Disposal: Triple rinse, puncture, or crush before disposal or recycling
Contaminated Packaging: Treat as hazardous chemical waste
Precautions: Do not discharge into sewer, landfill, or unapproved locations, prevent escape into the environment at all stages
UN Number: 1921
UN Proper Shipping Name: Pyrrolidine
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Labels Required: Flammable Liquid
Transport Precautions: Secure containers in upright position, protect from physical damage and extreme temperatures
Special Provisions: Ensure compliance with DOT, IATA, and IMDG requirements
TSCA: Listed in the U.S. Toxic Substances Control Act inventory
SARA 313: Not subject to reporting under Section 313
OSHA: Regulated as hazardous chemical
WHMIS (Canada): Class B2 (Flammable), Class D1B (Toxic Material)
REACH (EU): Registered under REACH; subject to restrictions on tonnage and industrial use
California Prop 65: Not listed
Other Regulations: Complies with relevant storage, handling, and transport regulations
