Sulfathiazole Sodium Material Safety Data Sheet (MSDS)

Identification

Product Name: Sulfathiazole Sodium
Chemical Formula: C9H8N3NaO2S2
Synonyms: Sodium sulfathiazole, Sulfathiazole monosodium salt
CAS Number: 4307-02-6
Recommended Uses: Used as an antibacterial agent in laboratory and pharmaceutical environments, frequently found in animal feed additives and veterinary medicine.
Supplier Details: Manufacturer and distributor addresses, phone numbers, and emergency contact information provided on packaging or as required by local regulations.

Hazard Identification

Hazard Classification: Classified as harmful if swallowed or inhaled; may cause allergic skin reaction; suspected of damaging organs through prolonged or repeated exposure.
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, skin irritation, may cause respiratory irritation, and can be harmful if ingested in considerable amounts.
Precautionary Statements: Avoid breathing dust. Wash exposed skin thoroughly. Wear suitable gloves and eye protection. In the event of exposure, follow prescribed safety protocols.

Composition / Information on Ingredients

Chemical Name: Sulfathiazole Sodium
Concentration: Typically ranges from 98-100% pure
Impurities: Trace organic or inorganic contaminants allowable under pharmacopeial standards
Other Components: No significant additives; always check certification of analysis for specific lot information.

First Aid Measures

Inhalation: Relocate to fresh air, keep in a position comfortable for breathing, seek medical attention if symptoms like coughing or shortness of breath persist.
Skin Contact: Remove contaminated clothing, wash affected area with soap and plenty of water, do not use solvents or thinners, call a physician if irritation develops.
Eye Contact: Rinse cautiously with plenty of water for several minutes, remove contact lenses if present, continue rinsing, and get medical advice if irritation occurs.
Ingestion: Rinse mouth, drink water to dilute, and immediately call a poison control center or physician. Do not induce vomiting unless specifically directed by medical personnel.

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical powder, carbon dioxide (CO2), or foam depending on fire severity and surrounding materials.
Specific Hazards: Releases toxic fumes of nitrogen oxides, sulfur oxides, and sodium compounds under fire conditions; avoid inhalation of combustion products.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus, full protective gear, and avoid direct contact with dust and smoke.
Advice for Firefighters: Approach from upwind to minimize risk; contain run-off to prevent environmental contamination.

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid dust formation, and wear recommended personal protective equipment, including gloves and goggles.
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid entering drains, waterways, or sewers; notify authorities if significant release occurs.
Methods for Cleanup: Collect spilled product with a damp cloth or absorbent, place in sealed, labeled container for disposal, and clean surface thoroughly with water.

Handling and Storage

Handling Guidelines: Use in well-ventilated areas, avoid generating dust, and keep away from food or beverages. Practice good industrial hygiene and wash hands before breaks.
Storage Conditions: Store in tightly closed containers in cool, dry, and well-ventilated spaces away from incompatible substances and direct sunlight. Protect from moisture, extreme temperatures, and keep separated from oxidizing agents.
Equipment Requirements: Use non-sparking tools and equipment rated for chemical use.

Exposure Controls and Personal Protection

Engineering Controls: Work under local exhaust ventilation and, if possible, in enclosed processes to limit dust exposure; install air filtration where appropriate.
Personal Protective Equipment: Safety glasses or goggles, lightweight chemical-resistant gloves (nitrile or neoprene), laboratory coats or coveralls, and, if necessary, approved particulate respirator.
Hygiene Measures: Avoid eating, drinking, or smoking in working area. Wash hands and face after handling chemicals, change contaminated clothing and clean thoroughly before reuse.

Physical and Chemical Properties

Appearance: White to off-white crystalline powder, odorless
Molecular Weight: 263.29 g/mol
Melting Point: Around 220-224 °C (with decomposition)
Solubility: Highly soluble in water, slightly soluble in ethanol, nearly insoluble in chloroform or ether
pH (1% solution): Generally 7.0-9.5
Vapor Pressure: Not significant under normal conditions
Other Properties: Stable under normal storage and handling, hygroscopic if exposed to air for extended periods.

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Incompatible Materials: Strong oxidizing agents, acids, and bases; moisture can cause degradation
Decomposition Products: Hazardous gases like nitrogen oxides, sulfur oxides, and sodium-based fumes can form during excessive heating or burning
Polymerization: Product does not polymerize or self-react under standard usage.

Toxicological Information

Acute Toxicity: Low to moderate toxicity; ingestion of high quantities may cause gastrointestinal disturbances, nausea, vomiting, diarrhea
Skin Irritation: Possible allergic reactions or dermatitis on prolonged or repeated contact
Eye Contact: Dust may cause redness, irritation, and possible damage if not washed away promptly
Inhalation: Respiratory irritation may occur after inhalation of dust; asthmatics or sensitive individuals more prone to adverse effects
Chronic Effects: Extended exposure may affect liver or kidneys, rarely blood dyscrasia or allergic sensitization can develop
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA.

Ecological Information

Aquatic Toxicity: May cause harmful effects to aquatic environments if released in significant amounts; not readily biodegradable
Mobility: Readily disperses in water, moderate mobility in soil
Persistence and Degradability: Not quickly broken down by standard environmental processes
Bioaccumulation: Low risk of bioaccumulation due to high solubility and metabolic breakdown in organisms
Other Effects: Avoid disposal into natural water bodies due to possible long-term impacts on aquatic flora and fauna.

Disposal Considerations

Waste Treatment Methods: Place contaminated material, including PPE and cleaning tools, in a sealed, labeled hazardous waste container; follow local, regional, and federal rules for pharmaceutical and chemical disposal
Incineration/Other Methods: Authorized waste disposal contractors handle incineration; chemical recycling not commonly supported
Environmental Protection: Prevent waste from entering drains or water courses; never dispose with household garbage.

Transport Information

UN Number: Not regulated as a dangerous good under transport regulations
Transport Hazard Class: Not assigned
Packing Group: Not applicable
Special Precautions: Transport in original, tightly closed containers; shield from moisture and incompatible cargo; fix securely to avoid spillage during movement.
Labeling Requirements: Label container with chemical name, hazard classification, and emergency contact details.

Regulatory Information

International Inventories: Listed in chemical regulatory lists for Europe (EINECS/ELINCS), US (TSCA), and APAC region
OSHA Status: Hazardous as defined by OSHA Hazard Communication Standard
SARA Title III: Not subject to Section 313 reporting requirements
Other Regulations: Complies with REACH and local environmental management standards; workplace exposure guidelines and safety procedures published by agencies such as NIOSH and ACGIH.
Labeling: Compliant with GHS standards, including signal words, hazard pictograms, and precautionary statements on outer packaging and product documentation.