Product Name: Sulfamethoxy Pyrazine
Synonyms: 4-Amino-N-(5-methoxy-3-pyrazinyl) benzenesulfonamide
Chemical Formula: C11H12N4O3S
Molecular Weight: 280.31 g/mol
CAS Number: 74578-19-1
Intended Use: Used as an antibacterial agent in both clinical and research contexts.
Manufacturer: Contact relevant supplier or manufacturer for origin and batch details.
Emergency Number: Supplier emergency contact required for spill, exposure, and incident advice.
Classification: According to GHS, classified as hazardous based on acute toxicity and skin sensitization.
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause an allergic skin reaction, toxic if swallowed or inhaled, suspected of causing genetic defects.
Pictograms: Exclamation mark, health hazard symbol.
Precautionary Statements: Avoid breathing dust or fumes, wear protective gloves, wash hands thoroughly after handling, store in well-ventilated areas, use only outdoors or in well-ventilated spaces, avoid release to environment.
Other Hazards: Dust forms may pose explosion risk in air, chemical is not classified as flammable but can emit noxious fumes under fire conditions.
Substance: Pure
Chemical Name: Sulfamethoxy Pyrazine
Concentration: 100%
Additives: None
Impurities: No significant impurities relevant for hazard classification.
EC Number: 278-692-0
Inhalation: Remove exposed person to fresh air immediately, keep at rest and seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing, wash effected area thoroughly with soap and water, seek medical advice if irritation occurs.
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses when present, continue rinsing, seek medical attention.
Ingestion: Rinse mouth, do not induce vomiting unless instructed by medical personnel, seek immediate medical help.
Most Important Symptoms/Effects: Irritation of respiratory tract, skin rash, burning sensation of eyes or skin, headache, dizziness, and gastrointestinal discomfort
Advice to Physicians: Treat symptomatically, monitor for allergic response and respiratory complications.
Suitable Extinguishing Media: Use dry chemical, foam, carbon dioxide, or water spray.
Unsuitable Media: Avoid direct water jet on chemical, which can spread burning material.
Specific Hazards: Decomposition produces toxic fumes such as nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide.
Protective Equipment for Firefighters: Wear full protective gear, including self-contained breathing apparatus.
Additional Information: Move containers from fire area if safe, cool containers with water spray.
Personal Precautions: Ventilate area, avoid dust generation, evacuate non-essential personnel.
Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat, respiratory protection if dust forms in high concentration.
Environmental Measures: Prevent release to waterways, drains, and soil.
Containment and Cleanup: Sweep up and collect spilled material with non-sparking tools, place in labeled container for disposal according to local regulations, wash spill site after material clearance.
Handling: Use in well-ventilated spaces, avoid dust generation, avoid contact with eyes, skin, or clothing, do not eat, drink, or smoke in handling areas, wash hands thoroughly after handling.
Storage: Store tightly closed in original container in a cool, dry, well-ventilated place, keep away from incompatible materials such as acids, strong oxidizers, and reducing agents, protect from direct sunlight and moisture.
Incompatibles: Strong acids, oxidizing agents, bases, reducing materials.
Special Precautions: Use secondary containment to guard against container rupture or leak.
Exposure Limits: No specific occupational exposure limits established. Use workplace guidelines for dusts.
Engineering Controls: Use local exhaust ventilation or process enclosures, avoid dispersion of dust.
Eye Protection: Chemical splash goggles or face shield.
Skin Protection: Chemical-resistant gloves (nitrile, PVC), lab coat or body suit.
Respiratory Protection: If airborne dust risk exists, use NIOSH-approved respirator.
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing promptly.
Appearance: White to off-white crystalline powder.
Odor: Odorless or very faint characteristic smell.
pH: Not available.
Melting Point/Freezing Point: 208-215°C
Boiling Point: Not applicable (decomposes on heating).
Flash Point: Not available.
Flammability: Non-flammable solid.
Explosive Properties: Dust may form explosive mixture in air.
Vapor Pressure: Negligible.
Solubility: Sparingly soluble in water, soluble in ethanol and DMSO.
Partition Coefficient (log Pow): Not determined.
Vapor Density: Not determined.
Autoignition Temperature: Not determined.
Decomposition Temperature: > 220°C
Molecular Weight: 280.31 g/mol
Chemical Stability: Stable under recommended handling and storage conditions.
Hazardous Reactions: Reacts with oxidizers, acids, and bases, decomposition leads to toxic gas emission.
Conditions to Avoid: Excessive heat, humidity, direct sunlight.
Incompatible Materials: Strong acids, strong bases, oxidizing agents.
Hazardous Decomposition Products: Ammonia, nitrogen oxides, sulfur dioxide, carbon monoxide and carbon dioxide may evolve upon burning or decomposition.
Acute Toxicity: Harmful if swallowed or inhaled, estimated LD50 (oral, rat): > 2000 mg/kg.
Skin Corrosion/Irritation: May cause irritation or allergic skin reaction.
Serious Eye Damage/Irritation: Risk of eye irritation on exposure.
Respiratory Sensitization: Inhalation may cause respiratory irritation or allergic symptoms.
Germ Cell Mutagenicity: Data suggest possible mutagenic effects; handle with care.
Carcinogenicity: Not listed by IARC, NTP, or OSHA as probable carcinogen.
Reproductive Toxicity: No reproductive studies available; precaution advised.
Specific Target Organ Toxicity: No confirmed data for repeated exposure target organ effects.
Other Information: Sensitive or allergic individuals may react at much lower exposures.
Ecotoxicity: Expected to cause hazard to aquatic life in high concentrations; limited data available.
Persistence and Degradability: Not readily biodegradable, may persist in environment.
Bioaccumulation Potential: Potential for bioaccumulation exists but unconfirmed.
Mobility in Soil: Mobility depends on environmental factors; chemical may leach in water-saturated soils.
Other Adverse Effects: Discharge into water bodies may cause harmful effects; avoid environmental release.
Waste Treatment Methods: Dispose according to recognized chemical waste procedures.
Product Disposal: Incinerate or landfill at approved facility; do not allow entry into surface water or drains.
Contaminated Packaging: Triple rinse and offer clean containers for recycling or disposal.
Special Precautions: Consult local hazardous waste authorities; avoid disposal in regular trash.
UN Number: Not regulated for transport under international rules.
UN Proper Shipping Name: Not classified as a dangerous good.
Transport Hazard Class: Not assigned.
Packing Group: Not assigned.
Environmental Hazards: Not classified as marine pollutant.
Special Precautions for User: Ensure packaging is undamaged, do not transport with food or feed.
Transport in Bulk: Not applicable.
Safety, Health and Environmental Regulations: OSHA hazardous chemical (United States), TSCA inventory status: consult supplier for confirmation.
EU Regulations: Not listed under REACH Annex XIV or XVII restrictions, observe national regulations for workplace safety.
Other International Regulations: Handle as pharmaceutical or research chemical under local authority guidance.
Inventory Listings: Check inventories in country of use, including AICS (Australia), DSL/NDSL (Canada), EINECS/ELINCS (Europe), ENCS (Japan), PICCS (Philippines), IECSC (China), and NZIoC (New Zealand).
Labeling Requirements: Provide clear hazard communication as required by the Globally Harmonized System (GHS).
