Product Name: (R)-1-Tert-Butyloxycarbonyl-3-Hydroxypiperidine
Chemical Formula: C10H19NO3
Synonyms: Boc-3-hydroxypiperidine, tert-butyl (R)-3-hydroxypiperidine-1-carboxylate
CAS Number: 143307-27-9
Recommended Use: Laboratory chemical, pharmaceutical intermediate
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Classification: Irritant (according to GHS and OSHA), eye irritation, skin irritation
Signal Word: Warning
Hazard Statements: Causes skin irritation, may cause moderate eye irritation, harmful if inhaled in dust or powder form
Pictogram: Exclamation mark (for irritants)
Precautionary Statements: Avoid breathing dust, wear gloves, wash contaminated skin thoroughly after handling, do not eat, drink or smoke during use, use in a well-ventilated area
Chemical Identity: (R)-1-Tert-Butyloxycarbonyl-3-Hydroxypiperidine
Concentration: >98% by weight
Impurities: Trace, not expected to contribute to hazard classification
Additives: None known
Molecular Weight: 201.27 g/mol
Inhalation: Move to fresh air, seek medical attention if coughing or other symptoms develop, rinse mouth if possible
Skin Contact: Remove contaminated clothing, wash exposed skin with soap and water, seek medical help if irritation persists
Eye Contact: Rinse gently with plenty of water for at least 15 minutes while holding eyelids apart, remove contact lenses if safe to do so, get medical advice if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, get medical attention promptly
Notes to Physician: Treat symptomatically, monitor for respiratory or allergic reactions, provide supportive care as needed
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Specific Hazards: Combustion produces carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear
Additional Advice: Move containers from fire area if it is possible to do so safely, cool tank/container with water spray, avoid breathing fumes
Personal Precautions: Use personal protective equipment, avoid contact with skin and eyes, avoid breathing dust
Environmental Precautions: Do not let product enter drains or surface waters, contain spillage
Methods for Cleanup: Collect dry powder with shovel or authorized HEPA vacuum, transfer to properly labeled containers for disposal, ventilate area and wash with soapy water after cleanup
Handling: Wear suitable gloves, safety glasses, and lab coats, use only in well-ventilated areas, avoid creating dust and keep containers tightly closed
Storage: Store in original container away from incompatible substances such as strong oxidizers, acids, or moisture, keep at room temperature and protect from direct sunlight, clearly label all containers
Exposure Limits: No specific occupational exposure limit set, handle as an irritant
Engineering Controls: Work in chemical fume hood or ventilated work area, use local exhaust to control dust
Personal Protective Equipment: Safety glasses with side shields or chemical goggles, disposable or nitrile gloves, laboratory coats or protective clothing, NIOSH-approved dust mask if dust exposure risk is likely
Hygiene Measures: Wash hands before breaks and after work, remove contaminated clothing before entering eating areas
Appearance: White to off-white crystalline powder
Odor: Faint, characteristic organic odor
Odor Threshold: Not available
pH: Not applicable in solid form, weak basic in solution
Melting Point: 89-93°C
Boiling Point: No data, decomposes before boiling
Flash Point: No data available
Evaporation Rate: Not applicable, solid
Flammability: Not highly flammable, combustible dust possible
Vapor Pressure: Negligible at room temperature
Solubility: Soluble in organic solvents like methanol, ethanol, and partially in water
Partition Coefficient (log Kow): No data available
Autoignition Temperature: No data available
Decomposition Temperature: >220°C
Viscosity: Not applicable to solids
Chemical Stability: Stable under recommended conditions
Conditions to Avoid: Excessive heat, open flame, moisture, incompatible chemicals
Incompatible Materials: Strong oxidizers, acids, some bases
Hazardous Decomposition Products: May emit carbon oxides, nitrogen oxides under combustion, potentially irritating fumes
Acute Toxicity: Not acutely toxic in low quantities, dust may cause respiratory irritation
Skin Corrosion/Irritation: Causes mild to moderate irritation, especially on prolonged contact
Serious Eye Damage/Irritation: Causes eye irritation, redness, discomfort
Respiratory or Skin Sensitization: Not recognized as a sensitizer, dust may aggravate asthma
Chronic Effects: Long-term exposure not studied, avoid repeated exposure
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenic Effects: No data available
Reproductive Toxicity: No data available
Toxicity to Aquatic Life: No detailed studies, likely low hazard due to limited solubility and low volatility
Persistence and Degradability: Expected to degrade slowly under environmental conditions
Bioaccumulative Potential: No significant bioaccumulation anticipated based on physical properties
Mobility in Soil: Limited mobility, not highly soluble
Other Adverse Effects: Avoid uncontrolled release to environment, not expected to contribute to ozone depletion or other global hazards
Waste Disposal: Dispose as hazardous laboratory waste according to local, regional, or national regulations, recommend incineration or chemical treatment
Container Disposal: Clean containers thoroughly before recycling, do not reuse for other chemicals, follow established protocols for hazardous waste containers
Precautionary Measures: Prevent material from entering soil, ditches, waterways, and drains
UN Number: Not regulated for transport under UN, IMDG, IATA
Transport Hazard Class: Not classified as dangerous goods
Packing Group: Not assigned
Proper Shipping Name: Chemical, not otherwise specified
Special Precautions: Protect from moisture and rough handling, keep containers tightly sealed during transit
Inventory Listings: Appears on most major chemical inventories (consult local inventory such as TSCA, EINECS, DSL for confirmation)
OSHA Hazard Classification: Irritant
SARA Title III: Not a listed hazardous chemical
California Proposition 65: Not listed
Other Regulations: Follow all local, state, and federal rules for use and disposal, ensure laboratory staff trained on hazard controls and spill procedures
