Product Name: (R)-1-Tert-Butyloxycarbonyl-3-Aminopiperidine
Synonyms: (R)-Boc-3-aminopiperidine, Boc-piperidine-3-amine
CAS Number: 145202-76-4
Recommended Use: Laboratory chemical, intermediate in pharmaceutical synthesis
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Classifications: Skin irritation (Category 2), Eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may irritate respiratory tract
Pictograms: Exclamation mark (GHS07)
Precautionary Statements: Avoid breathing dust or vapors, wash skin thoroughly after handling, wear protective gloves/protective clothing/eye protection/face protection, in case of inadequate ventilation wear respiratory protection
Physical Hazards: No strong physical hazard, not classified as flammable or explosive
Health Hazards: Prolonged exposure can lead to dermatitis, coughing, eye damage, possible risk of central nervous system effects
Environmental Hazards: May pose risk to aquatic environment, use containment to prevent soil and water contamination
Chemical Identity: (R)-1-Tert-Butyloxycarbonyl-3-Aminopiperidine
Chemical Formula: C10H20N2O2
Purity: ≥ 98%
Impurities: Trace residual solvents or intermediates from synthesis process
Molecular Weight: 200.28 g/mol
Substances: Contains no other substances at or above relevant concentrations that require mention according to regulation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do; continue rinsing, seek immediate medical attention if irritation persists
Skin Contact: Immediately remove contaminated clothing, wash affected skin with plenty of soap and water, seek medical attention for persistent redness or irritation
Inhalation: Remove to fresh air, monitor breathing, provide oxygen if available and symptoms are severe; seek medical advice if cough or irritation persists
Ingestion: Rinse mouth, give water to drink unless unconscious, do not induce vomiting, consult physician if large amount swallowed
Most Important Symptoms: Redness, tearing, burning, cough, dryness, headache, potential drowsiness with high exposure
Notes for Physician: Treat based on symptoms, provide symptomatic and supportive care
Extinguishing Media: Use dry chemical, CO2, foam, or water spray
Unsuitable Extinguishing Media: Avoid high-pressure water streams that can scatter material
Special Hazards: Combustion can produce toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides; containers can rupture in intense heat
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Move containers from fire area if safe, use water spray to cool unopened containers
Personal Precautions: Wear chemical-resistant gloves, safety goggles, and protective clothing, avoid breathing dust
Environmental Precautions: Prevent spill entering drains or waterways, contain spill with non-combustible absorbent
Cleanup Methods: Scoop or sweep spilled solid into a suitable container for disposal, wash area with soap and water after removal
Decontamination: Use mild detergent and rinse area thoroughly; ventilate area before re-entering
Disposal: See section on Disposal Considerations for correct disposal protocols
Handling: Wear appropriate personal protection, minimize dust generation, work in a well-ventilated area, use tools to avoid direct contact
Storage: Keep container tightly closed in a dry, cool, well-ventilated place, store away from incompatible materials such as strong oxidizers and acids
Special Requirements: Store at ambient to controlled room temperature, protect from moisture, ensure containers are labeled and sealed
Incompatibilities: Avoid storing with strong bases, oxidizing agents, or direct sunlight
Exposure Limits: No established occupational exposure limits, handle as a chemical with potential health effects
Engineering Controls: Use fume hood or local exhaust ventilation to limit airborne concentrations
Personal Protection: Wear NIOSH-approved respirator if dust exposure possible, use chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, lab coat or apron
Hygiene Measures: Avoid contact with skin and eyes, wash hands thoroughly after handling, do not eat or drink in work areas, remove contaminated clothing before leaving
Environmental Controls: Use containment strategies to avoid release to environment, monitor air quality in confined spaces
Appearance: White or off-white crystalline powder
Odor: Faint amine odor
Odor Threshold: Not determined
pH: Not available
Melting Point: 72-74°C
Boiling Point: Not readily available (likely decomposes)
Flash Point: Not determined
Evaporation Rate: Not applicable (solid)
Flammability: Material does not ignite easily under normal conditions
Solubility: Soluble in common organic solvents (e.g., methanol, DMSO), low solubility in water
Vapor Pressure: Not determined (negligible at room temperature)
Density: Approx. 1.05 g/cm³
Partition Coefficient (log Kow): Not determined
Auto-Ignition Temperature: Not established
Decomposition Temperature: Decomposes with release of toxic fumes
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: No dangerous reactions under normal conditions
Conditions to Avoid: Prolonged heat, open flames, high humidity, direct sunlight
Materials to Avoid: Strong oxidizers, acids, bases; avoid contact with water in large quantity
Hazardous Decomposition Products: Combustion or thermal decomposition produces CO, CO2, nitrogen oxides
Polymerization: Will not occur
Acute Toxicity: Exact LD50 not established, available information suggests low to moderate acute toxicity via oral, dermal, and inhalation routes
Skin Corrosion/Irritation: Causes irritation with possible redness, itching, and swelling
Serious Eye Damage/Irritation: May cause eye irritation, tearing, redness, and pain
Respiratory Sensitization: Dust or fumes may irritate nose, throat, or lungs
Chronic Effects: Repeated exposure may cause dermatitis or allergic skin reactions in sensitive individuals
Carcinogenicity: No data indicating carcinogenic properties
Mutagenicity: No specific data available, not expected to be mutagenic
Reproductive Toxicity: No studies indicating reproductive effects
Symptoms of Overexposure: Coughing, headache, drowsiness, dry skin, eye discomfort
Aquatic Toxicity: Data not available, but avoid exposure to environment and waterways due to possible adverse effects on aquatic organisms
Persistence and Degradability: Not expected to persist long-term; likely to undergo slow degradation in soil and water
Bioaccumulation Potential: Not anticipated, but log Kow not established
Mobility in Soil: Limited water solubility suggests low mobility
Other Adverse Effects: No established ozone-depleting potential, not known to contribute to global pollution problems
Waste Treatment: Collect solid waste in appropriate, labeled containers, dispose through licensed chemical disposal contractor; incineration recommended where allowed by local law
Container Disposal: Triple rinse before recycling or disposal, puncture and send to landfill or recycling facility if permitted
Local Regulations: Follow all local, regional, and national environmental disposal requirements
Special Precautions: Do not dispose in household garbage, sinks, or regular drains
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: None
Environmental Hazards: Not classified as a marine pollutant
Special Precautions for User: Ensure packaging is secure, avoid release during loading and transport, follow safe laboratory transport protocols
OSHA Status: Not specifically listed under OSHA hazardous chemicals
TSCA Inventory: May require notification for shipment or import, check listing before use in the United States
DSL/NDSL (Canada): Consult Canadian DSL or NDSL for status
EU Regulation: Not registered under REACH, may be used as research chemical with specific handling and documentation requirements
Other Relevant Regulations: Handle in accordance with workplace safety legislation and chemical hygiene plans to reduce risk of exposure and environmental harm
