Product Name: Pyrrolidine-3-ol
Chemical Formula: C4H9NO
CAS Number: 873-06-1
Synonyms: 3-Hydroxypyrrolidine
Recommended Use: Laboratory chemical, research and development
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Classification: Flammable liquid, Acute toxicity (oral), Skin irritation, Eye irritation
Signal Word: Warning
Hazard Statements: May cause respiratory tract irritation, Harmful if swallowed, May cause skin and eye irritation.
Pictograms: Exclamation mark, Flame
Precautionary Statements: Avoid breathing vapors or mists, Wash hands thoroughly after handling, Wear protective gloves and eye protection, Keep away from heat/sparks/open flames/hot surfaces.
Health Effects: Short-term exposure irritates the eyes, skin, and respiratory system. Swallowing the chemical can cause nausea, dizziness, and headaches. Skin absorption may lead to localized effects.
Environmental Effects: Toxic to aquatic organisms if spilled in large quantities. Persistent and mobile, potential for bioaccumulation.
Chemical Name: Pyrrolidine-3-ol
Concentration: ≥98%
Impurities: May contain trace organic solvents and unreacted starting materials at less than 2%.
CAS Number: 873-06-1
Inhalation: Remove affected person to fresh air immediately, keep at rest, and seek medical attention if symptoms persist. Mouth-to-mouth resuscitation may be required in severe cases.
Skin Contact: Take off contaminated clothing. Rinse skin with running water for a minimum of 15 minutes. Seek medical attention for persistent irritation.
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses when possible, continue rinsing until irritation subsides or medical care is available.
Ingestion: Rinse mouth thoroughly. Drink plenty of water but never induce vomiting unless directed by medical personnel. Call poison control or seek emergency care.
Most Important Symptoms: Burning sensation, redness, coughing, nausea, dizziness, headache.
Advice for Physician: Treat symptomatically, monitor airways, may require observation for chemical pneumonitis.
Suitable Extinguishing Media: Use alcohol-resistant foam, dry chemical, or carbon dioxide. Water spray may be effective for cooling but spreading risk exists.
Special Hazards: Vapors can form explosive mixtures with air. Decomposition produces toxic gases including carbon oxides and nitrogen oxides.
Protective Equipment for Firefighters: Full protective suit, self-contained breathing apparatus required.
Further Information: Evacuate nearby personnel, move containers from the area if it can be done safely. Run-off from firefighting may pollute waterways.
Personal Precautions: Use full protective clothing and respirators where aerosol formation is likely. Avoid contact with skin, eyes, and clothing.
Environmental Precautions: Block spillage from entering drains or watercourses. Use barriers and absorbent materials as needed.
Cleanup Procedure: Absorb spilled material with earth, sand, or inert absorbent. Collect in suitable containers for disposal. Ventilate affected area and wash residues away with copious amounts of water. Do not return unused material to the original container.
Handling: Handle in well-ventilated spaces only. Prevent formation of vapors and mists. Wear recommended personal protective equipment. Keep containers tightly closed when not in use.
Storage: Store in original packaging in a cool, dry area away from direct sunlight, sources of ignition, and incompatible substances such as strong oxidizers or acids. Do not store near food or beverages. Implement secondary containment as an extra precaution to prevent environmental release.
Engineering Controls: Use local exhaust ventilation or chemical fume hoods to maintain exposure below permissible limits. Install eye-wash stations and safety showers in the immediate work area.
Personal Protection: Protective gloves resistant to chemicals, tightly fitting safety goggles, flame-resistant lab coats, and proper respiratory protection during accidental release or high-concentration work.
Exposure Limits: Not specifically established, but minimize to the lowest practical level. Follow analogous guidelines for amine compounds.
Hygiene Measures: Wash thoroughly after handling, do not eat, drink, or smoke during use, remove contaminated clothing and wash before reuse.
Appearance: Colorless to pale yellow liquid
Odor: Amine-like, slightly fishy
Odor Threshold: Not available
pH: Basic in solution
Melting Point/Freezing Point: Approximately -10 °C
Boiling Point/Range: 185–190 °C
Flash Point: 72 °C (closed cup)
Evaporation Rate: Not available
Flammability: Combustible
Explosive Limits: Lower 2.1%, Upper 11.8% (estimated)
Vapor Pressure: ~4 mmHg at 25 °C
Vapor Density: Heavier than air
Relative Density: 1.02 g/cm³
Solubility: Completely miscible in water
Partition Coefficient (log Kow): -0.5 (estimated)
Auto-Ignition Temperature: 345 °C
Decomposition Temperature: Not precisely determined
Viscosity: Not measured
Chemical Stability: Stable under standard conditions of temperature and pressure.
Reactivity: Reacts vigorously with strong acids, oxidizers, anhydrides. Unstable at high temperatures and in the presence of ignition sources.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides if combusted or decomposed.
Polymerization: Not known to occur.
Incompatible Materials: Strong oxidizing agents, strong acids, acyl chlorides, acid anhydrides, halogens.
Acute Toxicity: Data on precise LD50 is limited. Expected to be moderately toxic by ingestion and inhalation, analogous to other low molecular weight amines.
Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Symptoms: Burning in the mouth, throat, and chest, headache, nausea, coughing, skin irritation, redness, tearing.
Chronic Effects: No long-term studies available. Frequent or prolonged exposure may cause dermatitis or chronic respiratory irritation.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or ACGIH.
Mutagenicity: No evidence reported.
Reproductive Toxicity: No data available for reproductive effects in humans.
Aquatic Toxicity: Harmful to fish and aquatic organisms at moderate concentrations based on amine structure similarity.
Persistence: May degrade gradually in environment, but mobile in soil and water.
Bioaccumulation: Unlikely to bioaccumulate due to high water solubility.
Other Effects: Adverse impact on aquatic life through changes in water pH.
Wastewater Impact: Treat before disposal, avoid uncontrolled release.
Waste Disposal: Collect and transfer waste material to authorized hazardous waste disposal facility. Neutralize carefully if permitted locally.
Contaminated Packaging: Rinse empty containers thoroughly, ensure material cannot escape into environment, dispose according to local and federal regulations.
Special Precautions: Wear appropriate personal protective equipment during all disposal tasks.
UN Number: Not allocated for small laboratory quantities, review bulk transport needs.
UN Proper Shipping Name: Pyrrolidine-3-ol solution
Transport Hazard Class: 3 (Flammable liquid, if applicable by quantity/concentration)
Packing Group: III
Marine Pollutant: No
Special Precautions: Secure containers, maintain upright and leak-proof during transit, keep away from incompatible materials and ignition sources.
EU Regulations: Not specifically classified under REACH, but general chemical safety applies.
US Regulations: Not listed as a hazardous substance under EPA SARA Title III or CERCLA. General workplace safety under OSHA applies.
Canada: WHMIS classification not assigned, but requires risk labeling.
International Inventories: May not appear on all country inventories. Check EINECS, TSCA, DSL.
Labeling Requirements: Comply with local and international transport, storage, and use regulations, provide hazard and precautionary labels in line with GHS standards.
