Chemical Name: Pyrazine
Synonyms: 1,4-Diazine
CAS Number: 290-37-9
Molecular Formula: C4H4N2
Recommended Use: Often used in the preparation of pharmaceuticals, as a flavoring agent, and in chemical research
Supplier: Manufacturer or supplier contact information should appear on the label
Emergency Phone: Provided by the supplier for urgent queries and emergencies
Classification: Flammable solid, Acute toxicity (oral and inhalation), Eye irritant
GHS Label Elements: Flame, Exclamation mark
Hazard Statements: Flammable solid; Harmful if swallowed; May cause respiratory irritation.
Precautionary Statements: Keep away from sources of ignition; Avoid breathing dust, vapors, or spray; Wash hands thoroughly after handling; Wear protective gloves and eye protection
Potential Health Effects: Inhalation may cause cough, dizziness, headache; Skin or eye contact triggers irritation symptoms; Ingestion leads to gastrointestinal discomfort; Prolonged exposure could damage respiratory organs
Component: Pyrazine
Concentration: Approximately 100% pure
CAS Number: 290-37-9
Impurities: Trace amounts, should be referenced from supplier's certificate of analysis if present
Inhalation: Move the affected person to fresh air right away; seek medical attention if symptoms persist
Skin Contact: Wash the area thoroughly with soap and water; remove contaminated clothing; medical attention is needed if irritation lingers
Eye Contact: Rinse with plenty of water for several minutes; remove contact lenses if present and easy to do; persistent discomfort warrants a medical check
Ingestion: Rinse mouth; never encourage vomiting in an unconscious person; call for medical help promptly
Advice for Medical Staff: Treat symptoms and support breathing and circulation as required; delayed pulmonary effects possible
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide for extinguishing
Specific Hazards: Emits toxic fumes under fire circumstances, including nitrogen oxides and carbon monoxide
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear to prevent exposure
Special Instructions: Keep cooling any exposed containers with water spray; avoid inhaling combustion products; stay upwind
Personal Precautions: Put on appropriate protective gear such as gloves, boots, and goggles; avoid direct contact with the material and its dust
Environmental Precautions: Prevent further leakage or spillage if safe; avoid reaching natural waterways or drains
Methods for Cleaning Up: Sweep up and collect spilled material in a suitable, labeled container for proper disposal; use non-sparking tools; ventilate the area well after cleanup
Handling: Practice good industrial hygiene by avoiding ingestion, inhalation, and skin contact; keep away from ignition sources and open flames; only handle open containers in well-ventilated areas
Storage: Store in a tightly sealed container; keep in a dry, cool, and well-ventilated location; separate from oxidizing agents and acids; label containers clearly, and limit access to qualified staff
Exposure Limits: No specific legal limits set; minimize exposure as much as possible
Engineering Controls: Use local exhaust ventilation or work in a chemical fume hood
Personal Protective Equipment: Chemical splash goggles, gloves resistant to chemicals (nitrile or neoprene), protective clothing as appropriate, respiratory protection if airborne levels rise above practical limits
Hygiene Measures: Wash hands, face, and arms after using this chemical; avoid eating, drinking, or smoking near work area
Appearance: Colorless to pale yellow crystalline solid
Odor: Nutty, sweet, earthy scent
Melting Point: 52–55 °C (125–131 °F)
Boiling Point: 115–117 °C (239–243 °F)
Flash Point: 29 °C (84 °F) (closed cup)
Solubility: Soluble in water, ethanol, and ether
Vapor Pressure: 17 mmHg (20 °C)
Density: About 1.03 g/cm³
pH: Neutral to slightly acidic in water solution
Flammability: Flammable solid; keep ignition sources away
Chemical Stability: Remains stable under normal temperatures and recommended storage conditions
Incompatible Materials: Oxidizing agents, acids, strong bases
Hazardous Decomposition Products: Breakdown produces nitrogen oxides, carbon monoxide, and carbon dioxide in fire
Conditions to Avoid: Sparks, heat, open flame, electrostatic discharge, moisture
Reactive Products: Avoid mixing with oxidizers or strong acids to prevent hazardous reactions
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Oral rat LD50 about 970 mg/kg; inhalation and skin effects depend on duration and concentration
Symptoms: Inhalation may produce headache, drowsiness; skin and eye exposure brings redness or irritation; ingestion leads to nausea or abdominal pain
Chronic Effects: Data on long-term exposure limited; not classified as a carcinogen
Sensitization: Not expected to cause skin or respiratory sensitization
Other Data: No evidence of mutagenicity or reproductive toxicity in available literature
Aquatic Toxicity: Data suggests moderate toxicity to fish and aquatic invertebrates
Persistence and Degradability: Not rapidly biodegradable; may persist in the environment for prolonged periods
Bioaccumulation: Low potential for bioaccumulation based on log Kow
Mobility in Soil: Will move through soil if spills happen but not highly mobile due to partial water solubility
Other Environmental Effects: Discharge into waterways may poison aquatic organisms
Waste Disposal: Dispose of as hazardous chemical waste following local, regional, and national regulations; do not flush into sewer systems
Contaminated Containers: Rinse thoroughly, then render unsuitable for reuse; handle as chemical waste
Special Precautions: Contact licensed waste disposal service; avoid environmental contamination during transport
UN Number: UN1325
UN Proper Shipping Name: Flammable solid, organic, n.o.s. (contains Pyrazine)
Transport Hazard Class: 4.1 (flammable solid)
Packing Group: III
Labeling Requirements: Flammable solid pictogram and classification
Special Transport Precautions: Secure containers for transit; avoid excessive heat or vibration; separate from acids and oxidizers during shipment
OSHA Status: Not classified as a highly hazardous chemical by OSHA
SARA Title III: Not subject to reporting under sections 302, 304, or 313
TSCA Status: Listed in the TSCA inventory in the United States
Other Regulatory References: Subject to chemical safety assessment in Europe, included in Canada’s DSL/NDSL list
Labeling Requirements: GHS-compliant hazard labeling, SDS reference required in all work areas using this compound
