Product Name: Piperidine-4-Carboxamide
Synonyms: 4-Piperidinecarboxamide, 4-Carbamoylpiperidine
CAS Number: 222727-87-3
Recommended Use: Laboratory chemical, research and development
Supplier: (Company name and address to be provided by manufacturer)
Contact Information: (Phone and emergency phone number as per supplier details)
Classification (GHS-US): Acute toxicity (oral, dermal), Skin irritation, Eye irritation
Hazard Statements: Harmful if swallowed; causes skin and eye irritation
Precautionary Statements: Avoid ingestion, skin and eye contact; wash thoroughly after handling; wear protective gloves, clothing, eye and face protection
Signal Word: Warning
Hazard Pictograms: Exclamation mark symbol
Potential Health Effects: Irritation to eyes, skin, and mucous membranes; possible respiratory tract irritation; ingestion might induce gastrointestinal disturbance
Environmental Effects: May cause harmful effects to aquatic life if released in significant quantities
Chemical Name: Piperidine-4-Carboxamide
Chemical Formula: C6H12N2O
Molecular Weight: 128.17 g/mol
Ingredient: Piperidine-4-Carboxamide
Concentration: ≥98% (by weight)
Impurities: Typically trace solvents, less than 2%, dependent on synthesis route
Chemical Abstracts Service No.: 222727-87-3
Inhalation: Move individual to fresh air, keep at rest in a position comfortable for breathing; seek medical advice if symptoms arise
Skin Contact: Remove contaminated clothing, wash affected area with soap and plenty of water; get medical attention for irritation or other symptoms
Eye Contact: Rinse cautiously with water for at least 15 minutes, keeping eyelids open; remove contact lenses if present and easy to do; seek medical care for continuing discomfort
Ingestion: Rinse mouth thoroughly; do not induce vomiting unless directed by medical personnel; consult a physician for further advice
Most Important Symptoms/Effects: Redness, irritation, pain in exposed tissues, possibly headache or nausea after significant exposure
Notes for Medical Professionals: Provide supportive treatment; treat symptomatically as per presentation
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or water spray
Special Hazards from Combustion: Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides possible during combustion
Protective Equipment for Firefighters: Wear positive pressure self-contained breathing apparatus, full protective gear
Firefighting Procedures: Use water spray to cool exposed containers; avoid inhalation of combustion products; isolate area and move unaffected personnel away
Personal Precautions: Keep unprotected individuals away, wear appropriate personal protective equipment including gloves, goggles, and lab coat
Environmental Precautions: Prevent further leakage or spillage if safe to do so; avoid discharge into drains, surface waters, or soil
Methods for Clean-up: Scoop up spill without generating dust using inert absorbent (sand, vermiculite); transfer to a properly labelled container for disposal; wash spill site with detergent and water; ensure area is ventilated
Handling: Handle in accordance with chemical hygiene and safety procedures; avoid generating dust or aerosols; use in a well-ventilated area with proper containment
Storage: Keep container tightly closed, stored in a cool, dry, and well-ventilated place; protect from moisture, incompatible materials, direct sunlight, and sources of ignition; store separately from oxidizers, acids, and strong bases; ensure all containers are correctly labelled and secure
Control Parameters: No occupational exposure limit established; use general ventilation or local exhaust as required
Engineering Controls: Use laboratory hoods, safety cabinets for procedures with powder or volatiles
Personal Protective Equipment: Gloves (nitrile or higher grade), safety goggles or face shield, lab coat or apron, closed footwear; respiratory protection if ventilation is inadequate
Hygiene Practices: Wash hands after handling, remove contaminated clothing, avoid eating, drinking, or smoking in work area
Environmental Exposure Controls: Proper ventilation, prevention of release into public sewage systems, containment infrastructure
Appearance: White to off-white solid, powder or crystalline
Odor: Slight, amine-like
Boiling Point: Not readily available; decompose before boiling
Melting Point: 114-118°C
pH (Solution): Data not established
Flash Point: Not available
Solubility: Soluble in water, some organic solvents (DMF, DMSO, methanol)
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): Not determined
Density: Estimated 1.1–1.2 g/cm³
Evaporation Rate: Non-volatile
Other Info: Tends to absorb moisture if left exposed to air
Chemical Stability: Stable at recommended storage temperature and conditions
Reactivity: Not expected to be reactive under normal chemical handling conditions
Hazardous Reactions: No hazardous polymerisation anticipated
Incompatible Materials: Strong oxidizers, acids, bases; avoid contact with moisture
Conditions to Avoid: Excessive heat, flame, static discharge, direct sunlight, exposure to air
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, ammonia
Acute Toxicity: Specific data not available, but structurally related amides show moderate oral and dermal toxicity
Skin Corrosion/Irritation: Can cause irritation with redness, itching
Eye Damage/Irritation: Causes eye irritation, redness, possible temporary blurred vision
Respiratory Sensitization: Irritating to respiratory tract if dust/aerosol inhaled
Skin Sensitization: No data, though potential exists based on structure
Germ Cell Mutagenicity: Not classified, no data
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: Data unavailable, handle cautiously
STOT-Single Exposure: May cause transient symptoms with significant exposure
STOT-Repeated Exposure: Chronic effects from ongoing low-level exposure are not established
Ecotoxicity: No established data; based on structural analogs, may exhibit moderate aquatic toxicity in high concentrations
Persistence and Degradability: Expected to be slowly biodegradable
Bioaccumulation Potential: Expected to be low due to water solubility
Mobility in Soil: May leach in moist conditions, especially if spilled in large quantity
Other Adverse Effects: Avoid release to environment, even small lab quantities can pose hazard to aquatic organisms if repeatedly disposed improperly
Waste Treatment Methods: Dispose of as hazardous chemical waste in accordance with local, regional, and national regulations
Contaminated Packaging: Treat empty containers as hazardous; triple rinse and offer for permitted landfill or incineration, follow institution or municipal policy
Other Considerations: Do not dispose via sewage or surface water systems; segregate from incompatible materials prior to disposal; document all disposal
UN Number: Not assigned for small research volumes; check with shipment authorities if shipping in bulk
Proper Shipping Name: Not classified as a hazardous material for ground or air transport in small quantities
Transport Hazard Class: Not regulated
Packing Group: Not classified
Special Precautions: Protect powder from moisture and physical damage; ensure all containers sealed and labelled
Environmental Hazards: Not a marine pollutant
Transport in Bulk: Not applicable for anticipated use
US TSCA Status: Not listed or only for research use; confirm with supplier
REACH Status (EU): Not registered, research-only use
SARA 302, 313: Not listed as extremely hazardous chemical
California Prop 65: Not listed
Workplace Safety: Subject to chemical safety legislation in workplace; laboratory workers should follow good laboratory practice and institution policies
Labeling Requirements: GHS-compliant label needed for all containers
Other International Regulations: Subject to regional and state regulations governing use of chemicals in scientific research; consult relevant authorities for compliance requirements
