Chemical Name: Piperazine-2-One
Synonyms: 2-Piperazinone, Piperazidin-2-one
CAS Number: 106-50-3
Recommended Use: Intermediate in chemical synthesis, research laboratories
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GHS Classification: Skin Irritant (Category 2); Eye Irritant (Category 2A); Specific Target Organ Toxicity (Repeated Exposure, Oral, Category 2)
Signal Word: Warning
Hazard Statements: Causes skin irritation; causes serious eye irritation; may cause damage to organs through prolonged or repeated exposure through oral intake
Pictograms: Exclamation mark symbol
Precautionary Statements: Wash skin thoroughly after handling; wear protective gloves and eye protection; avoid breathing dust or vapors; seek medical attention for persistent irritation
Other Hazards: Dust generated can create local irritation to respiratory tract.
Chemical Name: Piperazine-2-One
Concentration: >98% by weight
Molecular Formula: C4H8N2O
Molecular Weight: 100.12 g/mol
Impurities: Less than 2% by weight, primarily related piperazine compounds
Exposure Limits: No occupational exposure limits established specifically for Piperazine-2-One; control as a nuisance dust.
Inhalation: Remove from exposure area, move to fresh air, keep at rest, seek medical attention if symptoms develop or persist
Skin Contact: Remove contaminated clothing, rinse skin with water for at least 15 minutes, contact physician if irritation occurs
Eye Contact: Flush eyes with water for at least 15 minutes lifting eyelids often, remove contact lenses if possible, seek medical evaluation
Ingestion: Rinse mouth, drink water, avoid inducing vomiting, seek prompt medical advice
Symptoms / Effects: Skin redness or rash, burning in eyes, cough, sore throat, gastrointestinal discomfort
Suitable Extinguishing Media: Use CO2, dry powder, alcohol-resistant foam, water spray
Specific Hazards: Emits nitrogen oxides and carbon oxides at high temperatures; combustible dust poses explosion risk
Protective Equipment: Use self-contained breathing apparatus and full protective gear
Firefighting Actions: Isolate scene, remove containers from fire area if safe, cool containers with water stream
Personal Protection: Wear chemical-resistant gloves, goggles, dust mask, lab coat
Spill Response: Ventilate area, avoid dry sweeping, moisten with water to reduce dust, collect using non-sparking tools
Environmental Measures: Prevent material from entering drains or waterways
Disposal: Place material in closed containers for disposal following local regulations
Handling: Implement engineering controls to limit dust, avoid skin and eye contact, keep containers tightly sealed, use only in well-ventilated areas
Storage: Keep in original packaging, store in cool, dry location out of direct sunlight, keep away from sources of ignition and oxidizing agents, label all containers with chemical identity
Incompatibilities: Reacts with strong oxidizers, acids
Engineering Controls: Use local exhaust ventilation, fume hood or dust extraction, install eyewash stations and safety showers in work area
Personal Protective Equipment: Chemical splash goggles, gloves (nitrile or neoprene), long-sleeve lab coat, particulate respirator (N95 or better for powders), protective footwear
Hygiene Measures: Wash hands and face before breaks or eating, do not eat, drink, or smoke near work areas
Appearance: White to off-white crystalline powder
Odor: Mild, ammonia-like
Odor Threshold: Not available
pH: Slightly alkaline in solution (pH 7.5-9.0 at 1% solution)
Melting Point / Freezing Point: 145–150°C
Boiling Point / Range: Decomposes before boiling
Flash Point: >150°C
Evaporation Rate: Not applicable
Flammability: Low, but dust may form explosive mixtures
Vapor Pressure: Negligible at ambient conditions
Density: 1.15–1.18 g/cm³
Solubility: Soluble in water, alcohol; slightly soluble in ether
Partition Coefficient (log Kow): Estimated -1.4
Autoignition Temperature: Not determined
Decomposition Temperature: Above 150°C forms nitrogen oxides
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: May react with strong oxidizing agents, acids
Conditions to Avoid: Excess heat, humidity, open flames, generating dust clouds
Materials to Avoid: Strong acids, oxidizers, strong bases
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, ammonia, possibly irritating organic fumes
Acute Toxicity: Moderately toxic based on animal studies (LD50 oral rat >890 mg/kg)
Skin Corrosion/Irritation: May cause moderate irritation on contact
Serious Eye Damage/Irritation: Provokes eye redness, watering, possible corneal damage
Respiratory/Skin Sensitization: Repeated inhalation might trigger skin reactions or mild respiratory response
Chronic Effects: Prolonged or repeated exposure may produce liver or kidney effects, seen in lab animals at high doses
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a known carcinogen
Germ Cell Mutagenicity: No reliable studies of mutagenic effects
STOT (Specific Target Organ Toxicity): Evidence in animal data for liver, kidney impact after extended exposure
Reproductive Toxicity: No data suggesting particular hazard in reproductive health
Ecotoxicity: Low acute hazard to aquatic life, LC50 (fish, 96 hour) >100 mg/L
Persistence and Degradability: Expected to degrade in soil/water through microbial action
Bioaccumulative Potential: Low (log Kow shows easy water solubility, no biomagnification)
Mobility in Soil: Mobile; likely to migrate in water systems
Other Adverse Effects: No ozone depletion potential, not a volatile organic compound
Waste Treatment Methods: Dispose in accordance with local, regional, national, international regulations
Disposal Containers: Use sealed, labeled non-leaking containers
Recommended Treatment: High-temperature incineration or chemical treatment at licensed facility; do not dispose with household waste
Contaminated Packaging: Triple rinse, puncture, send to approved waste handler
Precautions: Minimize environmental release, record and track disposal as per company procedure
UN Number: Not classified as a dangerous good
UN Proper Shipping Name: Not allocated
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Transport Precautions: Ship in tightly closed original packaging, avoid rough handling, shield from moisture and heat sources
TSCA Listing: Listed in the U.S. Toxic Substances Control Act inventory
EINECS/ELINCS Number: 203-404-7
REACH Status: Registration not required for low volume; check for uses under ECHA
OSHA Hazard Communication: Classified as hazardous under OSHA criteria
Other Regulations: Not controlled under SARA Title III, not banned or restricted globally
WHMIS Classification: D2B (Toxic Material Causing Other Toxic Effects, Canada)
Inventory Status: Present in most international chemical inventories (Australia, Japan, Korea, China, Philippines)
