Product Name: Piperazine-1,4-Diethanol
Chemical Formula: C8H18N2O2
Synonyms: 2,2'-(Piperazine-1,4-diyl)diethanol
CAS Number: 50802-26-7
Recommended Use: Commonly serves as an intermediate in pharmaceuticals and specialty chemicals production
Manufacturer Information: Supplier details should be sourced from product label or safety data contact
Emergency Telephone Number: Locate manufacturer’s 24-hour emergency contact for immediate incidents
Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Specific target organ toxicity - single exposure (Category 3, respiratory tract irritation)
GHS Label Elements: Hazard pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause respiratory irritation
Precautionary Statements: Wear protective clothing, gloves, eye/face protection, avoid breathing dust, fume, gas, mist, vapors, spray, wash hands thoroughly after handling, use only outdoors or in a well-ventilated area
Chemical Identity: Piperazine-1,4-Diethanol
Concentration: ≥99% (for pure chemical forms used in laboratories and manufacturing)
Impurities: Minor trace solvents or by-products may exist in technical grades
Other Components: No additives, stabilizers, or undisclosed substances in analytical-grade material
Formula Weight: 174.24 g/mol
Inhalation: Move affected person to fresh air immediately, maintain breathing, seek medical advice as soon as possible
Skin Contact: Remove contaminated clothing, rinse thoroughly with soap and water for at least 15 minutes, obtain medical attention if irritation remains
Eye Contact: Rinse carefully with water for several minutes, remove contact lenses if present and easy to do, keep flushing, prompt medical assistance recommended
Ingestion: Rinse mouth, do not induce vomiting, never give anything by mouth to an unconscious person, consult a poison center or doctor right away
Symptoms: Irritation of respiratory tract, burning of skin or eyes, gastrointestinal discomfort if swallowed
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide for small fires
Specific Hazards: May release toxic fumes of nitrogen oxides, carbon oxides on thermal decomposition
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear to avoid exposure
Special Precautions: Evacuate area and fight fire from a safe distance, prevent runoff from contaminating waterways
Personal Precautions: Evacuate unnecessary personnel, don protective equipment including gloves, goggles, and mask
Environmental Precautions: Prevent spillage from entering drains, sewers, or natural waterways, contain large spills with sand, earth, or inert material
Spill Cleanup: Absorb small liquid spills on inert material and transfer to a chemical waste container, ventilate area thoroughly, wash spill site after material pickup
Disposal: Containers must be properly labeled and disposed of through certified hazardous waste handlers
Safe Handling: Avoid direct contact with skin, eyes, or clothing, use only with adequate ventilation or suitable exhaust systems, do not eat, drink, or smoke while handling this chemical
Storage Conditions: Store in a tightly sealed container in a cool, dry, and well-ventilated place, keep out of direct sunlight and away from incompatible materials such as strong oxidizers and acids
Storage Class: Chemical storage areas designed to minimize cross-contamination and provide secondary containment
Incompatibilities: Avoid contact with reactive or oxidizing agents
Exposure Limits: No established occupational exposure limits from OSHA, NIOSH, or ACGIH
Engineering Controls: Use local exhaust ventilation, chemical fume hoods, or process enclosures to control airborne contamination
Personal Protection: Wear chemical-resistant gloves (nitrile, neoprene), close-fitting safety goggles, laboratory coat or protective clothing
Respiratory Protection: Employ certified respirators during dust, vapor, or aerosol formation conditions
Hygiene Measures: Practice routine hand washing and removal of contaminated clothing before eating or using the restroom
Appearance: White to pale yellow crystalline solid
Odor: Mild, amine-like
Melting Point: 97–101°C
Boiling Point: Decomposes before boiling
pH Value: Basic in water solution
Solubility: Freely soluble in water and polar organic solvents
Vapor Pressure: Negligible at ambient temperatures
Density: 1.13 g/cm³ at 20°C
Flash Point: Not flammable under typical use conditions
Partition Coefficient (log Pow): <1 (expected to have low potential for bioaccumulation)
Chemical Stability: Remains stable under normal storage and handling conditions
Possibility of Hazardous Reactions: Reacts strongly with strong oxidizers and acids, exothermic reactions possible
Hazardous Decomposition Products: Can produce toxic fumes of nitrogen oxides and carbon oxides during thermal decomposition
Conditions to Avoid: Extreme temperatures, moisture, contamination with incompatible substances
Polymerization: Not known to undergo dangerous polymerization
Acute Toxicity: Based on similar compounds, can cause irritation to skin, eyes, or respiratory tract; limited data on oral/dermal LD50 values
Skin Corrosion/Irritation: Causes pronounced irritation in rabbit skin models
Serious Eye Damage/Irritation: Produces moderate to severe irritation in animal studies
Respiratory Sensitization: Prolonged inhalation may trigger irritation, coughing, difficulty breathing
Carcinogenicity: No data pointing toward carcinogenic risk according to current regulatory sources
Reproductive Toxicity: No recognized evidence for adverse reproductive impact
Repeated Dose Toxicity: Data insufficient for firm conclusions; chronic high-level exposures not advised
Other Effects: Ingestion can lead to gastrointestinal irritation or symptoms such as nausea and discomfort
Ecotoxicity: Data on aquatic toxicity remain limited, but related amine-containing compounds may be mildly to moderately toxic for aquatic organisms
Persistence and Degradability: Based on structure, expected to be readily biodegradable under aerobic conditions
Bioaccumulation Potential: Low, due to high water solubility and low partition coefficient
Mobility in Soil: Highly mobile, leaching into soils and surface waters is possible
Other Adverse Effects: No significant ozone depletion, photochemical, or global warming potential associated with this compound
Product Disposal: Handle as hazardous chemical waste, follow local and national regulations for disposal or incineration at licensed waste facility
Contaminated Packaging: Decontaminate before recycling if possible, or dispose with hazardous waste
Precautions: Prevent chemical from entering water, soil, or storm drains
Regulatory Disposal Guidance: Consult local, regional, or national environmental and waste authorities for proper guidance
UN Number: Not regulated for ground, sea, or air transport in most jurisdictions
Proper Shipping Name: Not classified as hazardous for transport
Transport Hazard Class: No assigned class
Packing Group: Not applicable for non-hazardous material
Special Precautions: Avoid extreme temperatures and moisture during transit, ensure packaging is sound and properly labeled for safety
International Inventories: Present on most chemical inventories (US TSCA, EU EINECS/REACH, Canadian DSL, Australian AICS)
OSHA Hazard Chemicals: Considered hazardous material based on GHS/OSHA criteria
SARA Title III: Not listed under Section 302, 304, 313 as ‘extremely hazardous’ or a toxic release chemical
California Prop 65: Not listed as carcinogen or reproductive toxin
Other Regulations: Subject to workplace safety rules, chemical hygiene practices, and proper hazard communication standards
