Material Safety Data Sheet: Piperazin-2-One

Identification

Product Name: Piperazin-2-One
Chemical Formula: C4H8N2O
Synonyms: 2-Piperazinone, 2-Oxopiperazine
CAS Number: 503-34-4
Recommended Use: Laboratory chemical, intermediate in organic synthesis
Supplier: Chemical provider details as per procurement
Emergency Contact: Local poison control center or chemical emergency line

Hazard Identification

GHS Classification: Not classified as hazardous under GHS
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Potential Health Effects: May cause mild skin and eye irritation, inhalation can provoke respiratory irritation, repeated or prolonged exposure can dry or crack skin
Signal Word: Warning
Pictograms: None required
Hazard Statements: May cause respiratory irritation, possible slight health effects upon contact
Precautionary Statements: Use in well-ventilated area, wear suitable protective clothing, avoid direct contact

Composition / Information on Ingredients

Chemical Name: Piperazin-2-One
Concentration: 98% or greater
Impurities: Water, trace organic contaminants <2%
EC Number: 207-963-2
Molecular Weight: 100.12 g/mol

First Aid Measures

Inhalation: Move to fresh air, respiratory support if breathing is hard, seek medical help for persistent symptoms
Skin Contact: Wash with soap and water for 15 minutes, remove contaminated clothing, do not reuse clothing until cleaned
Eye Contact: Rinse with gentle flow of water for at least 10 minutes, do not rub, eye exam for irritation
Ingestion: Rinse mouth, drink water if the affected person is conscious, never force someone to vomit, medical attention if discomfort continues
Most Important Symptoms: Local irritation, mild inflammation, no chronic effects reported at low exposure
Medical Attention: Symptomatic treatment only

Fire-Fighting Measures

Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Hazards: In combustion, may emit nitrogen oxides, carbon monoxide, and carbon dioxide
Protective Equipment: Firefighters require self-contained breathing apparatus; use protective gear to prevent contact
Fire Fighting Instructions: Remove containers from fire area if this can be done safely, keep surrounding containers cool with water spray
Unusual Fire Hazards: No particular sensitivity to impact or static discharge, behaves as typical organic solid in fire

Accidental Release Measures

Personal Protection: Wear gloves, goggles, lab coat, avoid breathing dust, assure ventilation during cleanup
Environmental Precautions: Prevent spills from entering drains, sewers, or waterways
Methods for Cleaning Up: Sweep up powders without generating dust, place in suitable containers for disposal, ventilate area and wash with plenty of water after removal
Emergency Procedures: Evacuate area if dust is excessive, restrict access during large spills
Small Spills: Collect with damp cloth, dispose of bag with standard solid waste procedures

Handling and Storage

Safe Handling: Avoid contact with skin and eyes, prevent inhalation of dust, work in fume hood if possible
General Hygiene: Wash hands before breaks and after handling, remove contaminated clothing before eating or drinking
Incompatible Materials: Strong oxidizers, strong acids
Storage Conditions: Keep in tightly closed original container, store in cool, dry, well-ventilated location
Storage Temperature: Room temperature, away from heat sources and sunlight
Packaging Materials: Use containers made of polyethylene, glass, or stainless steel

Exposure Controls and Personal Protection

Occupational Exposure Limits: None established for Piperazin-2-One
Engineering Controls: General or local exhaust ventilation to keep dust levels low
Personal Protective Equipment: Safety goggles, dust mask or respirator, gloves (nitrile or neoprene), laboratory coat
Hygiene Practices: Do not eat, drink, or smoke while using, wash hands and face thoroughly
Environmental Controls: Prevent material from entering soil, water systems, or drains

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Nearly odorless
pH (1% solution): Slightly alkaline
Melting Point: 149°C – 153°C
Boiling Point: Not available (decomposes)
Solubility: Soluble in water, ethanol
Density: About 1.3 g/cm³
Vapor Pressure: Negligible at room temperature
Vapor Density: Not established
Flash Point: Not easily flammable, not measured
Partition Coefficient (log Pow): Not determined
Evaporation Rate: Not relevant for solid

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Incompatible Materials: Strong acids, strong oxidizing agents—possible violent reaction
Conditions to Avoid: Excess heat, humid or moist conditions, direct sunlight
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides upon combustion
Polymerization: Does not polymerize under normal conditions

Toxicological Information

Acute Toxicity: Low toxicity expected, oral LD50 (rat) > 2000 mg/kg
Skin Corrosion/Irritation: Mild irritation in rare cases
Serious Eye Damage/Irritation: Possible mild, transient irritation
Respiratory Sensitization: Not a known sensitizer
Carcinogenicity: Not classified as carcinogenic
Reproductive Toxicity: No data for reproductive harm
Long-term Effects: No known chronic effects
Experience with Humans: No major incidents reported in occupational exposure

Ecological Information

Ecotoxicity: No data indicate toxicity to aquatic life at typical concentrations
Persistence and Degradability: Readily biodegradable in soil and water
Bioaccumulative Potential: Low potential, no evidence of significant accumulation
Mobility in Soil: Moderate, expected to dissolve and move with water
Other Adverse Effects: No significant ozone depletion or groundwater contamination
Aquatic Release: Limit discharges into surface water due to general chemical safety practices

Disposal Considerations

Waste Disposal Methods: Dispose of at authorized landfill or incinerator, avoid disposal to sewage system
Contaminated Packaging: Dispose of as unused product unless cleaned thoroughly
Special Precautions: Follow all local, regional, and national regulations for chemical disposal, waste collector must wear standard PPE

Transport Information

UN Number: Not regulated
Transport Hazard Class: Not classed as hazardous material
Packing Group: No restriction
Label: No special labeling required
Transport in Bulk: Not intended for bulk transport
Special Precautions for User: Package securely to prevent leaks and spills, handle as per chemical substance protocols

Regulatory Information

EU Regulation: Not classified under CLP Regulation (EC) No 1272/2008
US Federal Regulations: Not regulated under SARA, CERCLA, TSCA
Inventory Status: Listed on TSCA, EINECS/ELINCS, DSL
Workplace Safety: Regulated under workplace exposure and labeling guidelines for non-hazardous industrial substances
Other Information: Not subject to special restrictions, always refer to country-specific legislation for final requirements