Product Name: Α-Phenylpiperidine-2-Acetamide
Chemical Family: Piperidine derivatives
Recommended Use: Laboratory research, chemical synthesis
Synonyms: 2-Acetamido-1-phenylpiperidine
Manufacturer Name: ChemSpec Solutions
Manufacturer Address: 450 Research Blvd, Arcadia, CA 91007, USA
Contact Number: +1-800-555-1725
Emergency Telephone: CHEMTREC 1-800-424-9300
Product Code: APPA-060
CAS Number: 932-26-9
GHS Classification: Acute Toxicity (Oral) – Category 4, Skin Irritant – Category 2, Eye Irritant – Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin and eye irritation. May cause respiratory irritation. Toxic to aquatic life.
Pictograms: Exclamation Mark
Precautionary Statements: Do not breathe dust or vapor. Wear protective gloves and eye protection. Avoid release to environment. Wash hands after handling.
Potential Health Effects: Ingestion may lead to stomach pain, nausea. Skin exposure can cause rash, redness. Eye contact causes pain, watering. Inhalation stings the respiratory tract.
Classification System: OSHA Hazard Communication Standard (29 CFR 1910.1200)
Chemical Name: Α-Phenylpiperidine-2-Acetamide
Percentage: >98%
Molecular Formula: C13H16N2O
Molecular Weight: 216.28 g/mol
Impurities: Trace piperidine contaminants (<1%), solvents from synthesis (< 0.5%)
CAS Registry Number: 932-26-9
Component Description: White to off-white crystalline powder in pure form
Inhalation: Move to fresh air. Seek medical attention if symptoms develop such as coughing, shortness of breath, throat irritation.
Skin Contact: Rinse area under running water and remove contaminated clothing. Wash thoroughly with soap and water for at least 15 minutes.
Eye Contact: Rinse eyes with gentle stream of lukewarm water for at least 20 minutes, lifting eyelids occasionally. Remove contact lenses.
Ingestion: Rinse mouth with water. Do not induce vomiting. Drink small amounts of water only if person is conscious and alert. Get immediate medical assistance.
Most Important Symptoms: Burning sensation in eyes or skin, headache, irritation, nausea
Note to Physician: Symptomatic treatment. Observe for development of respiratory symptoms or delayed effects.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide (CO₂), or foam extinguishers on small fires. Use water spray to cool fire-exposed containers.
Unsuitable Extinguishing Media: High pressure water streams can spread chemically active dust.
Specific Hazards: May emit toxic or irritating fumes (oxides of nitrogen, carbon monoxide, carbon dioxide) in case of fire. Heavy smoke possible at high temperature.
Special Protective Equipment: Firefighters need full protective clothing and self-contained breathing apparatus.
Additional Advice: Remove all persons from proximity to fire, prevent runoff from reaching drains or water sources.
Personal Precautions: Use personal protection like gloves, goggles, and a dust mask or respirator. Ventilate area well. Evacuate non-essential staff.
Environmental Precautions: Prevent spillage from entering sewers, surface water, or groundwater. Avoid environmental release.
Clean-up Methods: Sweep up spilled material using non-sparking tools. Place in closed labeled containers for disposal. Wash area with detergent and water after cleanup.
Information for Emergency Responders: Wear appropriate chemical protective clothing and respiratory protection.
Safe Handling Procedures: Handle with care. Avoid dust generation, inhalation, and direct contact with skin or eyes. Use only in well-ventilated areas.
Technical Measures: Employ local exhaust ventilation. Use spark-resistant tools. Avoid eating, drinking, or smoking during use.
Storage Conditions: Store tightly closed in original container, in a cool, dry, well-ventilated place. Keep away from strong acids, oxidizers, and ignition sources.
Storage Temperature: Keep at 2–8°C (refrigerated) for long-term stability.
Special Packaging Materials: Use containers made of polyethylene, glass, or compatible plastic.
Occupational Exposure Limits: No established OSHA or ACGIH limits for compound. Work with general chemical exposure guidelines (TWA not to exceed 1 mg/m³).
Engineering Controls: Local exhaust ventilation, fume hoods, sealed transfer systems.
Respiratory Protection: Use NIOSH-approved dust mask or half-face respirator for airborne exposure risk.
Skin Protection: Wear chemical-resistant gloves (nitrile, butyl). Laboratory coat or apron recommended.
Eye Protection: Chemical safety goggles and face shield if splashing possible.
Hygiene Measures: Wash hands after handling, do not touch face. Discard contaminated clothing and wash before reuse.
Appearance: White to off-white crystalline solid
Odor: Faint, amine-like
Melting Point: 152–156°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in ethanol, DMSO; low water solubility
Density: 1.19 g/cm³
pH (1% solution): Neutral (6.8–7.2)
Vapor Pressure: Negligible at room temperature
Flash Point: >150°C
Autoignition Temperature: Not established
Explosive Limits: Data not available
Partition Coefficient (log Pow): 1.8 (calculated)
Chemical Stability: Stable under ambient conditions. Decomposes over 160°C.
Reactivity: Inert to most standard laboratory reagents in cold conditions.
Hazardous Reactions: Violent reaction possible with strong oxidizers or strong acids.
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides.
Conditions to Avoid: Heat, open flames, exposure to strong acids, oxidizing agents.
Incompatibility: Avoid copper, zinc, and their salts, peroxides.
Acute Toxicity: LD50 (oral, rat): 270 mg/kg (estimated based on analogs)
Skin Contact: May cause mild to moderate irritation.
Eye Contact: Causes discomfort, redness, watering.
Inhalation: Irritating to mucous membranes, coughing or sore throat possible.
Ingestion: Gastric distress, vomiting, drowsiness at high doses.
Chronic Toxicity: No studies on long-term effects. Treat as a compound of unknown chronic toxicity.
Carcinogenicity/Mutagenicity: No evidence of mutagenic or carcinogenic potential in available screening data.
Other Effects: Behavioral changes in test animals (reduced activity, mild sedation reported).
Ecotoxicity: Toxic to aquatic organisms in high concentration. LC50 (fish, 96h): 20–40 mg/L (estimated).
Persistence and Degradability: Slow degradation in soil. Not bioaccumulative but persistent in the absence of sunlight.
Bioaccumulative Potential: Low (log Kow <2). Does not concentrate in aquatic organisms.
Mobility in Soil: Moderately mobile. Adsorbs weakly to soil particles.
Other Adverse Effects: Avoid release to water or soil to minimize impact on microfauna and flora.
Waste Treatment Methods: Prevent from entering drains. Dispose of via licensed chemical disposal contractor.
Contaminated Packaging: Empty containers and packaging must be triple-rinsed, then managed as hazardous waste.
Recommended Disposal: Incinerate at authorized facility. Comply with all regional, national, and local regulations.
Environmental Precautions: Do not dump into any sewers, on the ground, or into any body of water.
UN Number: Not classified under UN Dangerous Goods
DOT/IATA/IMDG Classification: Not regulated as a hazardous material for ground/air/sea transport in small laboratory quantities
Hazard Class: Non-hazardous
Packing Group: Not applicable
Special Precautions: Double containment in sealed packaging recommended during transport to prevent accidental release.
Proper Shipping Name: Laboratory chemical, N.O.S.
US Federal Regulations: Not subject to TSCA reporting. Not listed on SARA Title III, Section 313.
OSHA: Subject to HazCom requirements; handle as hazardous substance under 29 CFR 1910.1200.
European Union Regulations: REACH pre-registered, not subject to registration if used exclusively for R&D.
Other International Regulations: Not controlled under Canadian WHMIS, Australian ADG, or Japanese PRTR Law.
Labeling Requirements: GHS-compliant pictograms, hazard and precautionary statements per CLP/GHS.
