Product Name: Phenazine Methosulphate
Synonyms: PMS, 1-Methoxyphenazinium methylsulfate
Chemical Formula: C13H12N2O•CH3SO4
CAS Number: 299-11-6
Recommended Use: Biochemical research, laboratory reagent for electron transfer studies
Supplier: (Supplier details vary by country and source; check local supplier information)
Emergency Contact: CHEMTREC 1-800-424-9300 (USA)
GHS Classification: Acute toxicity (Oral), Category 3; Skin irritation, Category 2; Eye irritation, Category 2A
Signal Word: Danger
Hazard Statements: Toxic if swallowed; Causes skin and eye irritation
Symbols: Skull and crossbones, Exclamation mark
Precautionary Statements: Avoid ingestion, breathing dust or powder, and skin or eye contact. Gloves, goggles, and protective lab clothing required.
Known Symptoms: Headache, nausea, abdominal pain, sore throat, irritation to eyes and skin, in severe cases, convulsions.
Long-term Exposure Risks: Liver and kidney function complications have appeared in some studies; take care with repeated exposure.
Chemical: Phenazine Methosulphate
Concentration: ≥ 98% (w/w)
CAS Number: 299-11-6
EC Number: 206-076-3
Impurities: Trace related phenazine derivatives (typically <1%)
Formula: C13H12N2O·CH3SO4
Molecular Weight: 306.35 g/mol
Inhalation: Take exposed person outside to fresh air. Seek medical attention for any difficulty breathing or persistent symptoms.
Skin Contact: Wash area with soap and water for several minutes. Remove contaminated clothing. If irritation persists, call a doctor.
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, keeping eyelids open. Medical evaluation recommended after flushing.
Ingestion: Rinse mouth thoroughly with water. Get immediate medical help. Do not give anything by mouth if unconscious.
Most important symptoms and effects: Mucous membrane irritation, headache, confusion. Show physician this data sheet upon arrival.
Suitable Extinguishing Media: Use dry chemical, CO2, or foam extinguishers. Water spray can cool containers, but may spread powder if not controlled.
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides, methyl sulfate under fire condition.
Protective Equipment: Full protective gear, self-contained breathing apparatus for heavy smoke situations.
Fire/Explosive Risk: Not highly flammable in powder form, but thermal decomposition releases toxic fumes.
Advice for firefighters: Evacuate area and approach upwind; keep cool with water spray.
Personal Precautions: Wear nitrile gloves, laboratory coat, safety goggles, respiratory protection (N95). Avoid creating dust.
Spill Cleanup: Scoop solids gently onto dry, compatible supporting spill tray or absorb onto inert material like vermiculite. Transfer into sealed container.
Environmental Precautions: Prevent entry into drains, waterways, or soil. Notify authorities if large spills threaten environment.
Clean-up Methods: Ventilate area, collect residues using appropriate chemical vacuum or damp paper towels. Dispose according to section 13.
Safe Handling: Work in a well-ventilated area, avoid breathing dust, wash hands thoroughly after use. Do not eat, drink, or smoke while handling.
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated chemical cabinet. Keep away from incompatible chemicals such as strong oxidizers and acids.
Maximum Storage Temperature: 8°C recommended.
Special Precautions: Use designated storage containers and clearly label the area. Keep away from sunlight and moisture. Prevent static discharge.
Control Parameters: No established OSHA or ACGIH exposure limits for this substance.
Engineering Controls: Chemical fume hood recommended for all manipulations. Use local exhaust.
Eye/Face Protection: Chemical goggles with side shields or face shield.
Skin Protection: Gloves made of nitrile rubber, lab coat, clothing that covers exposed skin.
Respiratory Protection: Dust mask (N95 or better) if dust generation likely.
Hygiene: Remove contaminated clothing, wash before reuse. Avoid contact with skin, eyes, and clothes. Wash hands after handling.
Appearance: Yellow to orange crystalline powder
Odor: No serious odor
Odor Threshold: Not established
pH: 5-7 (1% in water)
Melting Point/Freezing Point: 185-190°C (decomposes)
Boiling Point: Not measurable (decomposes before boiling)
Flash Point: Not applicable
Evaporation Rate: Not available
Flammability: Not classified as highly flammable
Vapor Pressure: Not available
Solubility: Soluble in water, ethanol, dimethylsulfoxide (DMSO)
Partition Coefficient (log Kow): Not determined
Vapor Density: Not available
Relative Density: About 1.32 g/cm3
Auto-ignition Temperature: Not available
Decomposition Temperature: >180°C
Viscosity: Not relevant
Chemical Stability: Stable at typical storage conditions up to 8°C; unstable at higher temperatures or prolonged exposure to light.
Reactivity: Slow oxidation in air, accelerated by light or heat.
Conditions to Avoid: Heat, moisture, strong light, contact with incompatible substances such as strong oxidizing agents.
Incompatible Materials: Strong acids, strong oxidizers, reducing agents.
Hazardous Decomposition: Produces methyl sulfate, nitrogen oxides, carbon monoxide, and carbon dioxide on decomposition.
Polymerization: Not known to occur.
Acute Toxicity: Oral LD50 (rat) 10-100 mg/kg; highly toxic if swallowed.
Chronic Toxicity: Limited data, but repeated exposure can lead to headaches, liver and kidney issues, possible blood disorders.
Skin Corrosion/Irritation: Moderate to severe skin irritant on prolonged contact.
Eye Damage/Irritation: Causes moderate to severe eye irritation.
Respiratory Sensitization: Not confirmed but dust may irritate respiratory tract.
Other Effects: May affect central nervous system in high exposures.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA.
Mutagenicity/Teratogenicity: Insufficient data. Handle with care due to general toxicity.
Aquatic Toxicity: Very toxic to aquatic life even in small quantities.
Persistence and Degradability: Not easily biodegradable, may persist in environment.
Bioaccumulative Potential: Unknown in aquatic organisms or soil, but anticipated to be low.
Mobility in Soil: Expected to be moderately mobile if released; soluble in water.
Other Adverse Effects: Disturbs aquatic ecosystems and potentially toxic for microorganism populations.
Prevention: Avoid release to waterways and soil; use containment controls in laboratory and industrial settings.
Waste Disposal: Treat as hazardous chemical waste. Collect for proper disposal at approved chemical waste facility.
Container Disposal: Triple-rinse, deface label, dispose according to local, state, and federal regulations.
Special Instructions: Do not attempt to neutralize or dilute in sinks or sewer systems. Avoid environmental release.
Regulations: Follow local EPA and hazardous waste guidelines; keep disposal records as required.
UN Number: 2811
UN Proper Shipping Name: Toxic Solid, Organic, N.O.S. (Phenazine Methosulfate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II (high hazard)
Marine Pollutant: Yes
Special Precautions During Transport: Secure packaging to prevent release, keep away from food and feedstuffs, mark as toxic.
DOT, IATA, IMDG: Regulated for all routes of transport.
TSCA: Listed
OSHA: Considered hazardous according to OSHA Hazard Communication Standard
SARA Title III: Not listed under sections 302, 304, 313
California Prop 65: Not currently listed
REACH/CLP: Subject to registration and restrictions in the EU
Labeling Requirements: GHS labels for acute oral toxicity and irritation hazards
Other Regulations: Handle as a keenly toxic and environmentally hazardous material. Local rules for chemical hygiene may apply.
