Product Name: Oxaceprol
Chemical Name: (2S)-N-Acetyl-4-hydroxy-L-proline
CAS Number: 3716-66-3
Molecular Formula: C7H11NO4
Molecular Weight: 173.17 g/mol
Synonyms: Oxaceprolum, Oxaceprolum, MMDP
Recommended Use: Pharmaceutical ingredient (used in treatment for osteoarthritis and inflammatory joint conditions)
Manufacturer Contact: Information provided by the supplier on packaging should be checked directly for up-to-date contact data.
Emergency Phone: Emergency phrases and phone contacts often develop over time with local regulations and suppliers, so consult shipping records for the most current data.
GHS Classification: Not classified as hazardous under GHS for supply and use.
Hazard Statements: No known significant hazards or critical risks in normal laboratory and medicinal handling.
Physical Hazards: May form dust that can irritate the eyes, respiratory tract, and skin.
Health Hazards: Inhalation, contact with skin or eyes, or ingestion may cause mild irritant responses.
Environmental Hazards: Low risk of environmental harm at volumes typical for laboratory or clinical scenarios.
Pictogram(s): Not assigned for standard laboratory and pharmaceutical handling thresholds.
Signal Word: None required.
Main Ingredient: Oxaceprol (2S)-N-Acetyl-4-hydroxy-L-proline (CAS 3716-66-3): >98%
Impurities: No hazardous impurities anticipated above 1% in finished pharmaceutical product.
Other Components: No additional components present at concentrations requiring disclosure.
Formulation Additives: Consult pharmaceutical preparation data for carrier excipients if handling finished tablets or capsules.
General Advice: Consult a doctor or poison center in all cases of exposure.
Inhalation: Move to fresh air. Seek medical assistance if coughing or respiratory symptoms persist.
Eye Contact: Rinse cautiously with water for at least fifteen minutes. Remove contact lenses, if worn and easy to do.
Skin Contact: Wash with soap and water. Take off contaminated clothing and wash before reuse.
Ingestion: Rinse mouth with water. Do not induce vomiting. Obtain medical attention if symptoms develop.
Note to Physician: No specific antidote. Treat symptomatically and supportively.
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Specific Hazards: Combustion may create irritating fumes (carbon oxides, nitric oxides).
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing.
Special Procedures: Avoid inhaling smoke. Cool containers near fire with water spray.
Explosion Data: Not sensitive to mechanical impact or static discharge under normal conditions.
Personal Precautions: Avoid dust formation. Ventilate the area. Use personal protective equipment as required.
Spill Response: Pick up with shovel or vacuum equipped with HEPA filter. Collect and place in a suitable container for proper disposal.
Environmental Precautions: Prevent product from entering drains or waterways; sweep and contain spills quickly.
Decontamination: Clean surface thoroughly with water and detergent. Dispose according to section on waste disposal.
Handling: Handle in accordance with good laboratory practices. Avoid contact with eyes and skin. Do not ingest. Implement local exhaust ventilation where dust may form.
Storage: Store tightly closed in a cool, dry, well-ventilated area. Avoid light and moisture. Do not store with incompatible chemicals (strong oxidizing agents).
Specific Use: Follow recommendations for pharmaceutical ingredients or laboratory chemicals as per standard operating procedures.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits.
Respiratory Protection: Use dust mask or respirator approved for particulates if airborne concentrations become high.
Eye Protection: Wear safety glasses with side shields or chemical goggles.
Skin Protection: Wear suitable gloves (nitrile recommended) and lab coat.
Other Protection: Wash hands thoroughly after handling. Do not eat, drink, or smoke in work areas.
Exposure Limits: No specific occupational exposure limits established; manage as for typical low-toxicity pharmaceutical powder.
Form: Solid, crystalline powder
Color: White to off-white
Odor: Odorless or with faint amino acid scent
pH: Approximately neutral in aqueous solution
Melting Point: 178-182°C
Boiling Point: Not determined; decomposes on heating
Solubility: Soluble in water, slightly soluble in alcohol
Vapor Pressure: Not applicable (non-volatile solid)
Density: Approximately 1.5 g/cm³
Partition Coefficient (log Kow): Data not available; expected to have low environmental mobility
Viscosity: Not applicable
Flash Point: Data not available; not flammable.
Chemical Stability: Stable under recommended storage conditions.
Reactivity: No dangerous reactions known under normal use.
Conditions to Avoid: Exposure to moisture, excessive heat, light.
Incompatible Materials: Strong oxidizing agents
Hazardous Decomposition: May produce carbon oxides, nitrogen oxides when heated to decomposition.
Polymerization: Will not occur.
Special Sensitivities: None noted beyond ordinary caution for dust.
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact.
Acute Toxicity: Expected to have low acute oral and dermal toxicity based on structure and use as a pharmaceutical.
Skin Irritation: May cause mild transient irritation.
Eye Irritation: Contact may result in temporary discomfort or redness.
Sensitization: Not expected to cause skin sensitization.
Carcinogenicity: No data indicating carcinogenic risk.
Mutagenicity: No mutagenic effects detected in standard tests.
Reproductive/Developmental Effects: No relevant adverse findings reported in available studies.
Chronic Effects: No long-term toxicity identified at expected occupational or therapeutic exposure levels.
Ecotoxicity: Expected to exhibit low toxicity to aquatic and terrestrial organisms.
Persistence/Degradability: Likely biodegradable under environmental conditions.
Bioaccumulation: No significant accumulation expected due to low lipophilicity.
Mobility in Soil: May move through soil in dissolved form, but risk to groundwater considered low.
Aquatic Fate: Soluble in water; unlikely to form hazardous residues in the aquatic environment at medically relevant concentrations.
Additional Notes: Prevent uncontrolled release to waterways to minimize potential impact.
Disposal Methods: Dispose of product through authorized chemical waste contractor. Do not dispose with household refuse or through drains.
Packaging Disposal: Rinse empty containers before recycling or discarding as permitted by local regulations.
Waste Codes: Not classified as hazardous waste at usual concentrations in pharmaceutical or lab context.
Precautions: Consult applicable regional, national, and local waste regulations.
UN Number: Not assigned.
UN Proper Shipping Name: Not regulated as dangerous goods.
Transport Hazard Class: Not regulated.
Packing Group: Not regulated.
IMDG/IATA/RID/ADR: Not a dangerous good under international transport codes.
Environmental Hazards: Product not considered a marine pollutant or environmental hazard for transport.
Health and Safety Regulations: Controlled under relevant pharmaceutical regulations for medical use and laboratory safety standards.
Workplace Safety: Standard hazard communication practices apply, including right-to-know and labeling in workplaces.
Registration: Check with local, regional, or national health authorities or agencies for specific registration status.
Other Regulatory Lists: Not listed as hazardous or toxic under US TSCA, EU REACH, or similar large chemical inventories for research and development or pharmaceutical use.
Special Labeling: No unique labeling required beyond standard chemical and pharmaceutical codes.
