Product Name: Opipramol
Chemical Name: 4-(3-(5H-dibenz[b,f]azepin-5-yl)propyl)-1-piperazinyl)-1-propanol dihydrochloride
Synonyms: Opipramol dihydrochloride, Insidon
CAS Number: 315-72-0
Intended Use: Pharmaceutical, research chemical for anxiety and depression therapies
Supplier: Major pharmaceutical companies or chemical distributors
Contact Information: Company address, emergency phone number, and email for technical inquiries
Formula: C23H29N3O·2HCl
Molecular Weight: 436.42 g/mol
Classification: Harmful if swallowed, irritant, risk of serious damage to health if inhaled or absorbed through skin
Signal Word: Warning
Hazard Statements: Can cause respiratory irritation, possible skin sensitizer, may cause pharmacological effects in accidental exposure
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Do not breathe dust or powder, use protective gloves and eye protection, wash skin thoroughly after handling, avoid contact with eyes and skin, keep away from food and drink
Substance: Opipramol (active, pure, no known excipients or diluents referred in standard reference samples)
Concentration: ≥98% (pharmaceutical grade)
CAS Number: 315-72-0
Relevant Impurities: None specified above 0.1% threshold in pharmaceutical standards
Other Components: May include hydrochloride for stabilization in salt form
General Advice: In case of health incident, remove from exposure area, call for medical assistance without delay
Inhalation: Take affected person to fresh air, monitor breathing, administer artificial respiration if breathing has stopped
Skin Contact: Wash area with large amounts of water and mild soap, remove contaminated clothing, consult medical attention on persistent irritation
Eye Contact: Gently rinse open eye with water, remove contact lenses if present and easy to do, seek prompt medical help
Ingestion: Rinse mouth thoroughly, never induce vomiting unless instructed by a poison control center, seek urgent medical evaluation
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Hazards from Combustion Products: Emits toxic fumes of nitrogen oxides, carbon oxides, hydrogen chloride, possible cyanide derivatives
Protective Equipment: Wear full protective gear including self-contained breathing apparatus, chemical splash goggles, chemical-resistant gloves
Additional Tips: Move containers away from fire area if possible, avoid breathing gases, prevent contaminated runoff to sewers or waterways
Personal Precautions: Wear protective gloves, lab coat, respirator, and safety goggles, ensure adequate ventilation, evacuate nonessential personnel
Environmental Precautions: Prevent spillage from entering drains, surface waters, or ground water, alert authorities about significant releases
Containment Methods: Avoid dust formation, sweep up material carefully, collect with non-sparking tools, transfer to properly labeled waste container
Cleanup Procedures: Wash spill area thoroughly with water and soap, ventilate area well, dispose as hazardous chemical waste
Safe Handling: Only handle in well-ventilated areas, avoid inhalation and contact with skin/eyes, wear appropriate PPE, do not eat or drink near product
Storage Conditions: Keep container tightly closed, store in a cool, dry, well-ventilated area, protect from light and incompatible substances (strong oxidizers, acids, alkalis)
Hygiene Practices: Remove and wash contaminated clothing before reuse, wash hands between tasks, avoid contamination of other chemicals
Incompatibilities: Do not mix with strong oxidizers or reducing agents, acids, alkali materials
Engineering Controls: Handle under chemical fume hood, promote local exhaust, use safety cabinets for storage and dispensing
Personal Protection: Chemical-resistant gloves (nitrile or neoprene), lab coat, chemical splash goggles, certified respirator if dust or aerosols are likely
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, or NIOSH for Opipramol
Monitoring: If exposure is significant, biological monitoring for symptoms, regular workplace air sampling may help
Additional Measures: Emergency shower and eyewash stations in area, no mouth pipetting, maintain clean working zones
Physical State: Solid, crystalline powder
Appearance: White to off-white
Odor: Odorless or faint pharmaceutical smell
Molecular Formula: C23H29N3O·2HCl
Molecular Weight: 436.42 g/mol
Melting Point: 228–230°C (dihydrochloride salt)
Boiling Point: Not applicable in solid form
Solubility: Freely soluble in water, insoluble in ether, soluble in methanol and ethanol
pH (1% solution): 4.5–5.0
Partition Coefficient (log Kow): Not publicly available
Vapor Pressure: Negligible at ambient temperature
Other Properties: Stable under normal laboratory conditions
Chemical Stability: Stable under recommended storage conditions, moisture sensitive, decomposes under strong heating
Reactive Hazards: Strong acids, strong bases, oxidative agents
Decomposition Products: Nitrogen oxides, carbon oxides, hydrogen chloride, possibly hazardous organic vapors
Hazardous Polymerization: Not expected under normal use or storage
Other Incompatibilities: Strong alkali, reducing agents may cause rapid degradation or hazardous decomposition
Routes of Exposure: Ingestion, inhalation, skin and eye contact
Acute Toxicity: LD50 (oral, rat): ~850 mg/kg, symptoms can include sedation, ataxia, tremor, respiratory depression, at high doses convulsions
Chronic Effects: Unknown in non-therapeutic exposure, may result in central nervous system and cardiovascular effects
Carcinogenicity: No evidence from animal studies, not listed as carcinogen by IARC, OSHA, or NTP
Reproductive Harm: No strong evidence, but limited data; should avoid exposure during pregnancy
Other Effects: May cause skin or eye irritation, respiratory tract discomfort, rare allergic reactions
Ecotoxicity: Data not widely available; as a pharmaceutical, concern exists that release into waterways could affect aquatic organisms
Persistence and Degradability: Likely decomposes slowly in aquatic systems, not significantly bioaccumulative based on chemical structure
Mobility: Moderately mobile in soils due to solubility in water
Other Information: Limits recommended for industrial wastewater discharge, no direct application in the environment
Waste Disposal Methods: Dispose of as hazardous chemical waste in accordance with all local, state, national, and international regulations
Product Disposal: Incinerate in approved facility, avoid flushing down drain or releasing to environment
Contaminated Packaging: Decontaminate containers before recycling or dispose with chemical waste
Additional Guidance: Do not reuse empty containers for other materials, ensure waste handlers wear proper PPE
UN Number: No specific UN number assigned for this substance
Proper Shipping Name: Not regulated as a dangerous good for land, sea, or air
Transport Hazard Class: Not classified
Packing Group: Not assigned
Special Precautions: Ship in tightly closed, properly labeled containers, protect from physical damage and moisture, document all shipments according to chemical control regulations
Inventory Status: Not specifically listed on TSCA (US), EINECS (EU), or similar inventories as a bulk chemical, regulated due to pharmaceutical status
Labeling Requirements: Risk and safety phrases for lab or commercial supply, chemical name, hazard warnings
Other Regulations: Prescription medicine in many countries, subject to special controls for shipment, handling, and workplace exposure
Worker Safety: OSHA lab safety standards apply, local occupational health and chemical exposure rules
Environmental: Discharge prevention applies for pharmaceutical manufacturing and research use, not considered as a Persistent Organic Pollutant
