Octahydrocyclopenta[C]Pyrrole made its entrance into organic chemistry circles during the mid-20th century, a period buzzing with life for nitrogen heterocycle research. Researchers chased after this molecule for its sturdy, saturated framework, eager to understand how its unique five-membered ring fused to a pyrrolidine core could change things in pharmaceuticals and crop protection chemistry. Progress didn’t happen overnight. Early attempts at synthesizing and isolating pure octahydrocyclopenta[C]pyrrole asked for tenacity and patience, with chemists wrestling the obstacles of multi-step hydrogenation because partial reduction of the parent aromatic derivatives created unwanted side products. I remember thumbing through thick journals and seeing stories of trial, error, and incremental victories, each breakthrough opening the doors a little wider for wider application.
Octahydrocyclopenta[C]pyrrole shows up in labs as a colorless to faintly yellow liquid or a crystalline powder, often determined by its purity and the temperature it meets you at. Laboratories reach for this molecule thanks to its stable, saturated ring, which lets it stand up to a range of reaction conditions. Suppliers put a premium on purity—organic synthesis demands it—and the slightest contamination with similar compounds can throw off everything downstream. Because of its place as a building block, the conversation always turns to yield, cost, and reproducibility. Real-world chemistry rarely lets you dodge those questions.
Octahydrocyclopenta[C]pyrrole brings a molar mass sitting at 111.2 g/mol, melting within the 35-40°C range, and boiling around 225°C. It dissolves readily in most common organic solvents, never enjoying much time in water thanks to its nonpolar backbone. Anyone working with the compound notices its mild, amine-like odor. The structure tells a story: a fused cyclopentane and pyrrolidine, with eight hydrogen atoms added relative to its parent aromatic system. This saturated structure gives it bumping stability and a reluctance to jump into reactions that would break aromaticity. The air- and moisture-stability make it a low-maintenance guest in most chemical storerooms, but anyone patient enough can coax it into forming useful intermediates using the right catalysts or reagents.
Manufacturers label every flask or vial with essentials: chemical formula (C8H15N), batch number, purity (often above 98%), precautionary handling notes, and safety hazard pictograms. Labels focus on real hazards—skin and eye irritation show up for those ignoring gloves and goggles—plus recommended storage instructions since improper sealing can spell oxidation or evaporation. I take labeling seriously, having seen how a minor oversight can lead to larger headaches in the lab or even safety incidents.
Chemists lean on catalytic hydrogenation as their method of choice, starting from aromatic cyclopenta[C]pyrrole. Hydrogen gas and a trusty palladium or platinum catalyst get the job done under controlled pressure and temperature. The reaction needs a watchful eye: incomplete hydrogenation leaves behind stubborn, partially reduced derivatives, while too much heat can degrade the product. Some researchers experiment with transfer hydrogenation to improve selectivity or scale up operations, though the basic approach stands as one of the most robust routes. Through practice, chemists learn that purification after synthesis—distillation or chromatographic separation—plays a major role in producing a reliable product batch after batch.
Octahydrocyclopenta[C]pyrrole opens several paths for further modification, showing a willingness to take on alkylating or acylating agents under controlled conditions. Its nitrogen center can form salts with acids or act as a nucleophile, inviting electrophiles for straightforward substitutions. The molecule resists oxidation, thanks to its saturated bonds, yet certain catalysts persuade it to participate in ring-opening reactions—a pathway that can generate more complex scaffolds for medicinal chemistry. The structure can host small chemical groups that tweak physical behaviors or reactivity, allowing researchers to customize downstream performance for whatever application lies ahead.
You’ll spot octahydrocyclopenta[C]pyrrole on supply catalogs under various titles: perhydrocyclopenta[C]pyrrole, hexahydroindolizidine, or even N-heterocyclic indolizidane. Each name feeds into the tangled web of chemical nomenclature. It pays to check structure and CAS number, not just the label, to sidestep messes that come from grabbing the wrong vial off a busy shelf. Many seasoned chemists keep a mental list of synonyms, old and new, to stay clear during literature searches or inventory checks.
The safety conversation never lasts long before shifting to gloves, goggles, fume hoods, and regular air monitoring. Although octahydrocyclopenta[C]pyrrole does not burn as eagerly as ethers or alkenes, inhalation of vapors or skin contact over time can create discomfort and health risks. Standard operational protocols include tight-container storage, prompt clean-up of any spills, and regular labeling updates. Regulatory bodies like OSHA outline exact procedures for handling amine-like compounds, reinforcing what most trained chemists pick up early in their careers. A spill in a crowded lab has a way of driving those lessons home.
Drug developers regard octahydrocyclopenta[C]pyrrole as a valuable starting point in the exploration of new CNS-active agents, antiviral candidates, and cardiovascular compounds. The molecule’s rigid, fused-ring structure mimics motifs in natural products like alkaloids, giving it a sort of plug-and-play appeal in medicinal scaffolding. Fine chemical and agricultural researchers also put octahydrocyclopenta[C]pyrrole to work when crafting new crop protection agents, hoping to surpass resistance or mimic plant signaling compounds. Industrial roles rarely involve it on its own; most often, modified derivatives end up as monomers, crosslinkers, or performance additives in specialty polymers or coatings.
R&D teams keep a steady eye on octahydrocyclopenta[C]pyrrole, eager to learn new tricks for late-stage functionalization, improved pharmacokinetic properties, or greener synthetic routes. A real challenge comes from making the molecule at scale with minimal waste, prompting chemists to test new catalyst systems, reusable supports, or milder reduction agents. Collaboration across synthetic chemists, process engineers, and regulatory consultants speeds up the translation from bench to pilot plant. Digital tools like retrosynthetic analysis or AI-driven reaction planning help close the gap further, but nothing beats hands-on skill and the intuition that comes from running reactions one after another.
Toxicity data for octahydrocyclopenta[C]pyrrole sticks close to established patterns for small heterocyclic amines. Acute toxicity appears mild—exposure in animal studies rarely leads to severe outcomes—but repeated or high-level inhalation still draws scrutiny, especially as researchers look beyond human safety to environmental persistence or aquatic toxicity. Metabolite studies track how the body breaks down the molecule, identifying which routes may produce bioactive or potentially harmful byproducts. Understanding and communicating this risk remains essential, not only for safe laboratory practice but also for downstream product stewardship, where end-users rely on clear safety guidance.
Octahydrocyclopenta[C]pyrrole stands on the threshold of broader application, partly because it delivers a rare combination of chemical stability and modifiability. Newer research projects explore ways to graft bioactive fragments directly onto the core skeleton, raising hopes for “next-generation” therapeutic candidates that tackle unmet medical needs. Green chemistry initiatives focus on using renewable feedstocks and lowering the carbon footprint of hydrogenation steps—an exciting shift driven both by regulation and optics. As computational drug discovery grows, screens spotlight octahydrocyclopenta[C]pyrrole-based scaffolds for their stability and physicochemical flexibility, likely pulling the compound into pipelines that wouldn’t have considered it a decade ago. Experience shows that well-understood, resilient intermediates like this usually find new relevance every few years as evolving challenges demand new tools. The next chapter for octahydrocyclopenta[C]pyrrole will likely look nothing like the last.
Octahydrocyclopenta[C]pyrrole sounds like something out of a chemistry exam, but it shows up behind the scenes in more places than most people ever realize. If you’ve ever caught a whiff of distinct, almost animalic scent in a high-end perfume, this molecule might just have played a part. It belongs to a group of chemicals that fragrance experts and chemists use to give products a sense of warmth or depth. That musky, lingering finish in fancy aftershaves? There’s a good chance this compound or its siblings contribute to it.
People don’t often think about how complex these fragrance formulas can get. I learned this firsthand listening to a perfumer describe mixing over 30 different compounds just to create the heart of a scent. Octahydrocyclopenta[C]pyrrole isn’t often the main player in a formula, but colleagues at fragrance labs have pointed out that it proves crucial for blending together certain notes that don’t want to cooperate on their own. Its structure helps lock those tricky scent elements together, a bit like putting the last piece in a complicated jigsaw puzzle.
This molecule isn’t all about scent, though. It pops up in drug research as well. The chemical ring structure found in octahydrocyclopenta[C]pyrrole forms a useful “scaffold” when developing new medicines. Medicinal chemists work with various ring structures when designing potential drug candidates, and the backbone of this particular ring can act as the starting point for antiviral or central nervous system treatments. In research settings, teams use it to help construct larger, more complex molecules that target specific receptors in the body. One nutrition scientist once told me about how research with related compounds led to small changes in appetite-regulating drugs. Every small change to the core makes a difference, and octahydrocyclopenta[C]pyrrole stands as a popular choice for building blocks.
Not all uses of this compound are free from controversy. Factories producing it need to keep a close eye on emissions and waste because some of the precursor chemicals can harm local ecosystems. Years ago, I read about manufacturing sites needing to overhaul waste treatment systems after finding traces of related compounds in nearby waterways. Researchers focus on finding greener processes. Some companies experiment with bio-based routes to the same compound, hoping to cut fossil resource use and reduce byproducts. These efforts matter. Choosing cleaner methods over time leads to safer workplaces, less community impact, and a healthier end product. No company wants news about contaminated water causing health concerns; taking care of the production process protects everyone down the line.
Octahydrocyclopenta[C]pyrrole shows how even forgettable-sounding chemicals build products and tools we use every day. From stabilizing scents to forming the skeletons of next-generation drugs, its influence spreads quietly. Responsible handling and smart chemistry push the future in the right direction. Cleaner methods, careful waste management, and a focus on creating value without polluting the community keep industry in check. People outside the lab may not see these molecules directly, but their importance shouldn’t go unnoticed.
Octahydrocyclopenta
The safety of a chemical often relies on what we know about its structure and behavior. Octahydrocyclopenta
I remember working through a batch synthesis where octahydrocyclopenta
No lab chief should expect miracles from safety sheets alone. Trusting your nose or hand as a detector brings more trouble than answers. Instead, use chemical fume hoods, keep nitrile gloves handy, and train yourself to respect the small, colorless chemicals as much as the flashy, reactive ones. Many near misses I’ve seen started with people underestimating a “mild” chemical, only for it to leak, splash, or vaporize unpredictably. Even simple storage turns risky if you leave this compound near acids or strong oxidizers. A secure, clearly labeled bottle tucked away from heat and sunlight is a smart start.
If you walk into a lab where folks laugh off goggles or ventilation, you’re more likely to see poor outcomes. I’ve worked in settings where peer pressure kept people sharp—one glance from a senior who sports full PPE, and you follow suit. Young researchers sometimes treat near-odorless or slow-acting chemicals as harmless, which sets them up for trouble. Training, reminders, and honest sharing of close calls keep teams safe.
Octahydrocyclopenta
Octahydrocyclopenta-C-pyrrole sounds like something pulled straight from a scientist’s notebook, and it isn’t something that just sits safely on any old shelf. Having spent a stint working in a university research chemistry lab, I know most folks don’t stumble onto good storage habits by accident. Responsible handling, rooted in knowledge and experience, keeps labs running and everyone safe.
Octahydrocyclopenta-C-pyrrole falls into the class of nitrogen heterocycles, often found as a clear or slightly yellowish liquid. Even though it doesn’t explode at room temperature, this isn’t a reason to let your guard down. Temperature swings—say from a careless open window in winter or overworked air conditioning in summer—can change vapor pressure inside its container. If the room gets too warm, vapor can build up, pressure climbs, and the risk for leaks or even breakage kicks in. So, room temperature, stabilized and steady, is best. Toss in a dry place, away from direct sunlight, and you reduce a surprising amount of risk.
A fume hood isn’t decoration; octahydrocyclopenta-C-pyrrole can give off fumes. Regular rooms with closed windows trap chemicals in the air. Daily exposure to chemical vapors can lead to chronic health issues over months or years. Good ventilation, and especially a working fume hood, turns a risky moment into a routine step.
Glass or chemical-resistant plastic bottles work well for this compound. I remember learning early on how careless selection—like storing in the wrong kind of plastic—can mean slow leaks, ruined samples, or even reactions with the bottle itself. Tight seals matter, not just to lock in vapors, but to block out moisture. Water in the bottle can lead to hydrolysis or, worse, open the door to unsafe byproducts. For anything that smells odd or develops a color shift, changing to a fresh container or disposing of it according to chemical waste protocols saves headaches later.
I’ve seen frantic searches for Material Safety Data Sheets when something spills, and those moments show just how important proper labeling is. Every bottle should carry a clear label, naming the contents, concentration, hazard level, and date received. Quick answers in tough situations help keep everyone calm and efficient. Safety goggles, gloves, and lab coats help create a physical barrier should an accident happen. Spill kits, usually within arm’s reach in a good lab, let you keep a small problem from becoming a crisis.
Regular training, whether from the safety office or monthly refreshers, keeps everybody confident about handling spills or other surprises. Agencies such as OSHA require strict adherence to best practices, and regular audits make sure folks don’t slip into lazy habits. Ignoring guidelines usually comes back to haunt the entire team.
Accidents can snowball in a blink. Staying methodical about labeling, storing, and using good containers builds up layers of protection for both people and research.
Smarter storage comes with experience, but a culture of safety built into every routine means lower risks for chemical handling in academic, industrial, or medical research labs. Keeping up with updated protocols brings peace of mind and keeps research moving ahead, safely.
OctahydrocyclopentaCpyrole sounds like a tangle of letters, but it reveals a story that shapes much of chemistry. Break the name down: “octahydro” points to eight extra hydrogens. “Cyclopenta” brings a five-membered ring. “Pyrrole” marks a nitrogen in that ring. This structure sits at a crossroad between saturated hydrocarbons and key biological molecules, like those sitting in our own cells.
Picture the molecule as a five-membered ring fused to a four-membered curve, with nitrogen settling quietly in one of the corners. Most lines between the atoms—carbon and nitrogen—don’t form double bonds. Think of it as a close-packed, flexible skeleton, not too rigid to break under pressure but tough enough to hold its shape. Every atom sits in a carefully chosen spot, giving this molecule its character and function.
Years in research labs taught me that simple structures can unlock radical advances, but many people brush over them. Chemists who first stuck to this backbone found that the fully saturated ring can slip into many chemical reactions, making it valuable for synthetic work. Its reduced, hydrogen-filled frame means it resists quick breakdown, a blessing in drug development or materials science.
Hydrogenating the parent compound, cyclopentaCpyrole, smoothes out tricky double bonds and creates a non-aromatic, bendy molecule. Ring size and saturation define its chemical personality, which shows up in everything from drug scaffolds to the backbone of new materials. One example—octahydro derivatives sometimes underlie medicines targeting inflammation or neurological disorders, indicating that this simple skeleton can drive big changes in health.
I saw struggles pop up in the lab when it came to handling saturated, nitrogenous cycles. These molecules don’t dissolve easily in just any solvent, and their flexibility means shape-shifting confuses analysis. Advanced NMR and X-ray diffraction data confirm the layout, but that often takes weeks to secure. Experienced chemists remember sweating over glassware, coaxing reactions to proceed, learning patience and adaptability.
Another reason this chemical matters: stability opens doors for design. Build on it, adjust substituents, slap on functional groups. Every tweak alters how this molecule interacts with receptors or enzymes. Chemists must balance between keeping the base intact and creating a useful compound. My colleagues and I spent entire months trying to craft derivatives that would perform just right without breaking down before we could test them.
The field doesn’t lack challenges. Synthesis can produce byproducts, and obtuse reaction conditions may limit scaling. As a solution, many teams now lean on green chemistry, mapping out new routes that cut out hazardous reagents and waste. I saw real progress after switching to recyclable solvents and renewable feedstocks, which not only made processes safer but also slashed costs.
Smaller companies benefit from open-access databases that store reliable spectra and crystal structures. Data sharing saves time and fights repetition. Collaboration often turned failed attempts in my own group into key lessons when shared with a broader network.
Diving into the details of the chemical structure of octahydrocyclopentaCpyrole may not sound exciting, but this unassuming scaffold supports much of what we use in medicine and materials science. Every atom’s placement, every bond’s direction, matters to someone trying to build something better, faster, or safer.
Octahydrocyclopenta
I remember years ago, searching for obscure reagents while working on a side project in graduate school. Traceable suppliers with a history of vetting their customers exist for nearly every rare chemical. Reputation matters, especially with molecules linked to research, pharmaceuticals, or other high-stakes industries. Sigma-Aldrich and TCI Chemicals serve as relied-upon sources for these specialty compounds. Both require proper credentials—a company account, proof of laboratory affiliation, and sometimes government paperwork depending on local regulations. Once a supplier gets a request, their staff checks credentials and may even ask about the intended use to make sure nothing shady is happening.
Finding a reliable supplier often means starting with a catalog search online. The top global suppliers usually show up first—let’s say Sigma-Aldrich, Alfa Aesar, or VWR International. Type the compound name or its CAS number and filter according to purity and packaging. Phone support can clarify stock status or help walk through the registration process. Their specialists answer technical questions, like storage instructions, reactivity, or any regulatory hoops to jump through.
Trusted chemical suppliers keep track of who buys what, for good reason. Octahydrocyclopenta
Checking the safety data before buying any specialty chemical stands as common practice. For octahydrocyclopenta
Cost gets steep fast for rare compounds. Buying only what’s absolutely needed pays off, not just for budget but for safety and storage reasons. From my own experience, small research teams benefit from joining a university purchasing consortium or a recognized industrial affiliate program. These programs unlock bulk rates, ensure compliance, and sometimes offer return options for unopened stock that might go out of spec before use.
The chemical supply world has shifted over time, stressing more transparency for both buyers and sellers. Better tracking keeps doors open for legitimate work while locking out those seeking to misuse materials. Suppliers help set safe boundaries, while researchers and buyers share the load by working through official channels and sharing knowledge about risks. Direct outreach, careful planning, and respect for safety have always guided me right, and those approaches matter more than ever in a world where borders mean less to commerce—and to risk.
Getting tough-to-find chemicals might seem daunting but those who follow the right paths usually get what they need for their science while keeping ethical standards front and center. That respect shapes not just research outcomes, but the larger community’s trust in how science is done.
![Octahydrocyclopenta[C]Pyrrole](https://alchemist-1317689233.cos.ap-nanjing.myqcloud.com/056fcdf6-b156-4184-af3b-70a401d743ac/images/2d/octahydrocyclopenta-c-pyrrole.png)
![Octahydrocyclopenta[C]Pyrrole](https://alchemist-1317689233.cos.ap-nanjing.myqcloud.com/056fcdf6-b156-4184-af3b-70a401d743ac/images/3d/octahydrocyclopenta-c-pyrrole.gif)
| Names | |
| Preferred IUPAC name | octahydro-1H-cyclopenta[c]pyrrole |
| Other names |
Hexahydroindolizine Octahydrocyclopenta[c]pyrrole Indolizidine |
| Pronunciation | /ˌɒk.təˌhaɪ.drəʊ.saɪ.kləʊˈpɛn.təˌsiːˈpaɪ.roʊl/ |
| Identifiers | |
| CAS Number | 497-23-4 |
| 3D model (JSmol) | `7O[C@@H]1CCCC2NCCC12` |
| Beilstein Reference | 134400 |
| ChEBI | CHEBI:38827 |
| ChEMBL | CHEMBL16337 |
| ChemSpider | 21578695 |
| DrugBank | DB01684 |
| ECHA InfoCard | 100.007.860 |
| EC Number | 208-922-0 |
| Gmelin Reference | 82262 |
| KEGG | C11249 |
| MeSH | D015555 |
| PubChem CID | 68490 |
| RTECS number | GU8575000 |
| UNII | ZT55F08UJ6 |
| UN number | UN3223 |
| Properties | |
| Chemical formula | C8H15N |
| Molar mass | 141.237 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Odor | amine-like |
| Density | 1.04 g/mL at 25 °C(lit.) |
| Solubility in water | Insoluble |
| log P | 0.43 |
| Vapor pressure | 0.25 mmHg (25 °C) |
| Acidity (pKa) | 11.27 |
| Basicity (pKb) | pKb = 3.30 |
| Magnetic susceptibility (χ) | -54.0×10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.483 |
| Viscosity | 8.03 mPa·s (25 °C) |
| Dipole moment | 2.57 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 311.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -105.1 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -4857.7 kJ/mol |
| Pharmacology | |
| ATC code | N07AX02 |
| Hazards | |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS05,GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P261, P280, P305+P351+P338, P337+P313 |
| NFPA 704 (fire diamond) | 1-2-0 |
| Flash point | 62 °C |
| Autoignition temperature | 205 °C |
| Explosive limits | 4.8–54.0% |
| Lethal dose or concentration | LD50 oral rat 706 mg/kg |
| LD50 (median dose) | LD50 (median dose): 316 mg/kg (rat, oral) |
| NIOSH | RN3675 |
| PEL (Permissible) | No OSHA PEL |
| REL (Recommended) | 5 mg/m³ |
| IDLH (Immediate danger) | 100 ppm |
| Related compounds | |
| Related compounds |
Indolizine Pyrrolo[1,2-a]pyridine Octahydroindolizine |
