Product Name: Nicotine Dihydrogen Ditartrate
Chemical Formula: C10H14N2 · 2C4H6O6
Synonyms: Nicotine ditartrate, Dihydrogen tartrate salt of nicotine
CAS Number: 65-31-6
Uses: Laboratory reagent, research chemical, potential pharmaceutical intermediate
Manufacturer Details: Provided on request, includes manufacturer’s address and contact number
Emergency Contact: Local poison control center or emergency medical services
Recommended Use Restrictions: Suitable for research, not intended for human consumption or medical treatment unless authorized
GHS Classification: Acute toxicity (oral, dermal, inhalation), Category 2; Skin irritation, Category 2; Eye irritation, Category 2
Label Elements: Skull and crossbones symbol, exclamation mark
Signal Word: Danger
Hazard Statements: Fatal if swallowed, in contact with skin, or if inhaled; Causes skin and eye irritation
Precautionary Statements: Avoid breathing dust or vapors; Wash thoroughly after handling; Use only outdoors or in a well-ventilated area; Wear protective gloves, clothing, and eye protection
Potential Health Effects: Severe central nervous system stimulation, nausea, vomiting, convulsions, possible death through respiratory failure; skin contact may cause rapid absorption and systemic toxicity
Chemical Name: Nicotine Dihydrogen Ditartrate
Concentration: Typically greater than 98% pure
Impurities and Stabilizing Additives: Trace moisture; amounts below 2%; no significant hazardous impurities listed
Relevant Mixtures: Sold as single compound; no mixture with non-hazardous substances unless specifically formulated
Inhalation: Move person to fresh air, keep at rest, seek immediate medical attention; provide artificial respiration if not breathing
Skin Contact: Wash all exposed areas with copious amounts of water and soap, remove contaminated clothing, seek medical help
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses, continue rinsing, obtain urgent medical care
Ingestion: Seek immediate medical attention, do not induce vomiting unless instructed by medical personnel, rinse mouth with water
Indications for Physicians: Treat symptoms; monitor for nicotine poisoning; activated charcoal may be indicated if ingestion occurred recently; support vital functions
Suitable Extinguishing Media: Foam, dry chemical, carbon dioxide, water spray
Specific Hazards Arising from Chemical: Toxic vapors such as carbon monoxide, nitrogen oxides may form; no explosive properties recorded but strong heating can cause decomposition
Special Protective Equipment: Firefighters need self-contained breathing apparatus and full protective suit
Advice for Firefighters: Approach from upwind direction; prevent runoff from contaminating water sources, evacuate area if significant smoke develops
Personal Precautions: Use personal protective equipment; avoid inhalation and skin/eye contact; evacuate unprotected personnel
Environmental Precautions: Prevent chemical from entering sewers, surface water, soil; report significant spills to local authorities
Methods for Cleaning Up: Collect with inert absorbent; place in labeled, closed container; ventilate area; wash site with plenty of water after removal of major residues; waste should be managed as hazardous
Handling Recommendations: Wear gloves, goggles, and lab coat; ensure proper ventilation or use fume hood; avoid eating, drinking, smoking during handling
Safe Storage Conditions: Store in tightly closed container in a cool, dry, well-ventilated place away from incompatible materials such as strong acids, bases, oxidizing agents
Incompatible Materials: Strong bases, oxidizers, reducing agents
Special Storage Requirements: Prevent moisture ingress, keep away from direct sunlight and sources of heat, protect container from physical damage
Exposure Limits: OSHA PEL not established for nicotine salts; ACGIH TLV (nicotine): 0.5 mg/m³ TWA
Engineering Controls: Use chemical fume hood, mechanical ventilation
Personal Protection: Nitrile gloves, chemical safety goggles, lab coat or disposable apron; respirators (NIOSH certified) if airborne concentration might exceed limits
Hygiene Measures: Wash hands after handling, avoid clothing contamination, remove contaminated clothing and wash before reuse
Physical State: Solid crystalline powder
Color: White to off-white
Odor: Bitter, characteristic (may resemble nicotine aroma)
Molecular Weight: 452.41 g/mol
Melting Point: Approx. 132-137°C (decomposition possible above this point)
Solubility: Readily soluble in water, slightly soluble in alcohols
pH (1% solution): 2.5–3.2
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at room temperature
Density: About 1.29 g/cm³
Partition Coefficient (log Kow): Low, expected to have poor lipophilicity in salt form
Chemical Stability: Stable under normal laboratory conditions
Conditions to Avoid: Strong heat, direct sunlight, moisture, incompatible substances
Materials to Avoid: Strong oxidizing agents, strong bases
Hazardous Decomposition Products: Toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides, other toxic substances possible upon burning or decomposition
Reactivity: No known hazardous polymerization; strong acids or bases may break down product, leading to release of nicotine base and tartrate decomposition
Acute Toxicity Data: Very toxic if ingested, inhaled or upon skin contact; oral LD50 (rat) for nicotine base: 50 mg/kg; for this salt, similar order of magnitude
Skin Corrosion/Irritation: Causes irritation and rapid systemic absorption
Serious Eye Damage/Irritation: Causes irritation and inflammation
Respiratory Sensitization: Inhalation risks include rapid onset of poisoning symptoms: nausea, salivation, vomiting, abdominal pain, respiratory difficulty, convulsions
Repeated Dose Toxicity: Chronic exposure may lead to neurological, cardiovascular, and gastrointestinal effects
Carcinogenicity: Not classified by IARC as carcinogenic, but nicotine increases risk in combination with tobacco use
Mutagenicity/Teratogenicity: Limited data, concerns for potential neurological impact
Symptoms of Exposure: Dizziness, tremors, increased salivation, nausea, diarrhea, confusion, convulsions, possible death at high doses
Ecotoxicity: Highly toxic to aquatic organisms; LC50 (fish): typically <10 mg/L (freshwater species)
Persistence and Biodegradability: Nicotine can degrade in environment, but may persist long enough to affect aquatic systems
Bioaccumulative Potential: Low for salt forms; likely to remain in water phase instead of bioaccumulating in animal tissue
Mobility in Soil: Expected to have moderate to high mobility; can leach into groundwater
Other Adverse Effects: Small amounts impact invertebrates, algae, and soil fauna; avoid environmental release
Waste Treatment Methods: Dispose of as hazardous chemical waste using licensed chemical disposal contractor
Contaminated Packaging: Triple rinse, treat rinse water as hazardous; puncture or crush empty containers to prevent reuse
Do Not: Release into drain, waterways, or urban refuse
Disposal Regulations: Comply with local, state, and national regulations specific to dangerous chemicals
UN Number: UN 1654 (Nicotine, solid)
UN Proper Shipping Name: Nicotine compounds, solid, n.o.s.
Transport Hazard Class: 6.1 (Toxic Substances)
Packing Group: I (substances presenting high danger)
Label Requirements: Toxic label, proper documentation including emergency contact
Transport Precautions: Ship in original, tightly sealed packaging; prevent spillage or leakage; inform carrier of toxic hazard
Special Precautions: Prohibit bulk shipment with foodstuffs, animal feed, or medical supplies
OSHA Status: Regulated as a hazardous material under the Hazard Communication Standard (29 CFR 1910.1200)
SARA Title III: Not specifically listed, but reportable if stored in significant quantities
TSCA Inventory: Nicotine and most nicotine salts appear on TSCA registry
International Regulations: Subject to regulation under REACH in Europe; WHMIS classification in Canada; regulated under chemical safety laws across Asia and Australia
Other Country Regulations: Strict controls and licensing in many countries, as component of controlled or toxic substances lists
Restrictions: Distribution and use restricted to qualified personnel, with proper regulatory compliance and documentation required at each transaction stage
