Product Name: Niclosamide Piperazine Salt
Chemical Formula: C13H8Cl2N2O4 · (C4H10N2)
CAS Number: 1659-24-9 (Niclosamide); 110-85-0 (Piperazine)
Recommended Use: Anthelmintic agent in animals and humans, laboratory chemical
Manufacturer: Select a supplier with pharmaceutical, veterinary, or chemical handling credentials.
Contact Information: Emergency response line and local healthcare authority contact should always be on hand for immediate reference.
Synonyms: Piperazine niclosamide salt
EC Number: 216-885-5
Classification: Hazardous substance for eyes, skin, and respiratory system
Signal Word: Warning
Hazard Statements: Skin and eye irritation, inhalation causes respiratory discomfort, suspected carcinogen status based on animal data
Pictograms: Exclamation mark for irritant, health hazard for chronic effects
Precautionary Statements: Avoid contact with skin, eyes, and clothing; do not breathe dust or vapor; wash hands thoroughly after handling
Potential Health Effects: Eye redness, headache, skin rash, throat irritation, mild nausea
Medical Conditions Aggravated: Pre-existing respiratory, skin, or eye conditions may worsen
Environmental Hazards: Toxic to aquatic organisms, keep away from drains
Niclosamide: 60-70%
Piperazine: 30-40%
Impurities: Less than 1% by mass, supplier-specific impurity profile
Additives: None declared, but stabilizers or anti-caking agents show up in some commercial samples
Molecular Weight: Approx. 470 g/mol (niclosamide piperazine combination)
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek immediate medical help
Inhalation: Move to fresh air, keep at rest in a position that helps breathing, provide oxygen if trained, medical attention if symptoms linger
Skin Contact: Rinse skin with lukewarm water for at least 15 minutes, remove contaminated clothing, wash with soap
Eye Contact: Flush with copious amounts of clean water for 20 minutes keeping eyelids open, call emergency services for persistent irritation
Note to Physicians: Symptomatic treatment, avoid gastric lavage unless clearly indicated, monitor for delayed symptoms
Self-protection: Use appropriate PPE during rescue
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, alcohol-resistant foam
Unsuitable Media: Avoid strong water jets that may spread powdered product
Special Hazards: Produces toxic and corrosive gases (HCl, NOx) during combustion
Firefighter Protection: Wear self-contained breathing apparatus, full protective gear
Advice: Contain runoff to prevent entry into sewers and waterways, fight fire from safe distance
Personal Precautions: Use proper PPE (nitrile gloves, safety goggles, dust mask or respirator)
Environmental Precautions: Protect drains, avoid release to natural waterways, contain spill
Containment: Sweep up with minimal dust formation, use damp material if needed, transfer to a suitable container for disposal
Cleanup Methods: Clean area thoroughly with water and detergent, ventilate if possible
Emergency Procedures: Isolate area, clear unnecessary personnel, follow local incident response protocols
Handling Precautions: Use in well-ventilated settings, avoid generation of dust, use PPE each time
Safe Storage Conditions: Cool, dry area away from heat, ignition sources, and sunlight, tightly sealed container
Incompatible Materials: Strong acids, bases, oxidizers
Hygiene Practices: Wash hands thoroughly after handling, never eat or drink near product
Special Instructions: Keep away from children, unauthorized personnel, and avoid storage near foodstuffs
Stability Statement: Store in original packaging, respect expiration dates
Exposure Limits: Not established for compound, but handle with limits used for irritant dusts (total dust: 10 mg/m³, respirable dust: 5 mg/m³)
Ventilation: Provide reliable exhaust in processing areas
Eye Protection: Safety goggles with side shields
Skin Protection: Chemical-resistant gloves, long-sleeved lab coat or coveralls
Respiratory Protection: Use respirator with P2 (or higher) filter
Other Protection: Eye wash station, emergency shower, refrain from contact with open wounds
Workplace Monitoring: Regular check of airborne levels, surfaces, and personnel exposure
Appearance: Off-white to light yellow crystalline powder
Odor: Slight, phenolic
pH (1% aqueous): About 6-8
Melting Point: Approximately 225°C (decomposes above this point)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Poor in water, better in ethanol or DMSO
Vapor Pressure: Negligible at room temperature
Density: Around 1.4 g/cm³
Partition Coefficient (Log Pow): Estimated >2, favors partitions in organic phases
Stability: Stable under recommended storage conditions, sensitive to excessive moisture and strong sunlight
Chemical Stability: Stays stable in closed containers below 25°C
Conditions to Avoid: Direct sunlight, heat, high humidity
Materials to Avoid: Strong acids, oxidizers, reducing agents
Hazardous Decomposition Products: HCl, CO, CO2, NOx under fire or extreme heat conditions
Polymerization Risk: No hazardous polymerization expected
Reactivity Notes: May release toxic vapors if decomposed or burned, will not react violently under normal transport or use
Acute Toxicity: Oral LD50 (rat) approx. 500 mg/kg, inhalation LC50 (rat) not well defined, skin absorption data not conclusive
Chronic Effects: Prolonged exposure may affect liver and kidney function, based on animal studies
Skin and Eye Irritation: Moderate irritation, possible allergic dermatitis
Carcinogenicity: Not IEC listed as carcinogen for humans, but some animal study findings warrant caution
Mutagenicity: Conflicting evidence, further research needed
Other Health Hazards: Precaution needed for pregnant women and young children, can cause mild neurotoxicity at high doses
Sensitization: May cause allergic reactions with repeated skin contact
Aquatic Toxicity: Highly toxic to fish and aquatic invertebrates, LC50 for Daphnia spp. <1 mg/L
Persistence: Compound shows limited biodegradability, persistent in soil and water
Bioaccumulation: Observed potential based on Log Pow value, risk of biomagnification in food chain
Soil Impact: Possible impacts on soil microorganisms and invertebrates
Mobility: Depot binding to sediment reduces movement but increases residence time
Special Precautions: Prevent release into waterways, drains, or the environment at large
Disposal Methods: Dispose of waste via licensed hazardous chemical handler, incineration recommended in controlled facility
Waste Code: Appropriate to local and state regulations, label as hazardous
Container Disposal: Triple-rinse with compatible solvent, puncture, and send to approved facility
Contaminated Packaging: Treat as hazardous, do not reuse for food or water
Special Instructions: Make sure to comply with all community rules for chemical waste
Down-the-Drain Disposal: Strongly discouraged due to aquatic impact
Recycling: Not suitable for recycling, destruction advised
UN Number: 2811 (Toxic Solid, Organic, n.o.s. – If applicable)
Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified (n.o.s.)
Transport Hazard Class: 6.1 (Toxic substance)
Packing Group: III (for less hazardous toxic solids)
Marine Pollutant: Yes
Special Transport Notes: Keep containers upright, sealed, and dry. Do not transport with food, feed, or medicine
Labeling: Toxic, Environmentally Hazardous
OSHA Status: Regulated as hazardous
EPA Regulation: Required registration number for pesticide uses
EU Directives: CLP Regulation (EC) No 1272/2008, REACH applies for inventory and usage restrictions
TSCA Inventory: Process as industrial chemical under US federal rules
Hazard Symbol: Xn (harmful), N (dangerous for the environment)
SARA 313: Not reportable in standard form
RoHS/WEEE: Not relevant for pharmaceutical or veterinary use, but always check substance restrictions
Other Country Standards: Local regulations change often, always consult up-to-date government guidelines
